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Seventy-two MF patients were compared with 72 matched healthy controls. Sleep disturbances were measured with the Pittsburgh Sleep Quality Index (PSQI) and the Insomnia Severity Index (ISI), with poor sleep quality defined as PSQI score > 5. Patients showed markedly higher PSQI and ISI median scores than controls, and logistic regression linked the study group to poor sleep quality for both instruments (p \u003C 0.0001).",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/prevalence-and-severity-of-sleep-disorders-in-patients-with-mycosis-fungoides-a-case-control-study/437771/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/prevalence-and-severity-of-sleep-disorders-in-patients-with-mycosis-fungoides-a-case-control-study/437771.png","ImageObject",300,407,{"name":92,"@type":93},"Bulrr","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How many patients were included in the case and control groups?","Question",{"text":112,"@type":113},"The case group included 72 patients with mycosis fungoides, and the control group included 72 matched healthy individuals.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which questionnaires were used to evaluate sleep disturbances?",{"text":117,"@type":113},"Sleep quality and insomnia severity were assessed using the Pittsburgh Sleep Quality Index (PSQI) and the Insomnia Severity Index (ISI).",{"name":119,"@type":110,"acceptedAnswer":120},"What was the main finding regarding sleep quality in MF patients?",{"text":121,"@type":113},"Both the prevalence and severity of sleep disorders were significantly higher in MF patients than in the matched healthy population.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},437771,1791002457,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":46,"preview_page_count":4},5909892115043,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","Wiley  \nJournal of Skin Cancer  \nVolume 2025, Article ID 5528328, 8 pages [https://doi.org/10.1155/jskc/5528328](https://doi.org/10.1155/jskc/5528328)  \nResearch Article  \nPrevalence and Severity of Sleep Disorders in Patients With Mycosis Fungoides: A Case-Control Study  \nAhmad Vafaeian , 1 Aidin Shahilooy , 1 Maryam Daneshpazhooh , 1  \nRobabeh Abedini , 1 Farid Mohamadi , 1 Ala Ehsani ,2 and Hamidreza Mahmoudi 1  \n1 Autoimmune Bullous Diseases Research Center, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran  \n2 School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran  \nCorrespondence should be addressed to Hamidreza Mahmoudi; [hr_mahmoody@yahoo.com](hr_mahmoody@yahoo.com)  \nReceived 28 November 2024; Revised 11 November 2025; Accepted 2 December 2025  \nAcademic Editor: Richa Sharma  \nCopyright © 2025 Ahmad Vafaeian et al. Journal of Skin Cancer published by John Wiley & Sons Ltd. Tis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \nIntroduction: Mycosis fungoides (MF) is the most common form of cutaneous T cell lymphoma. Given that MF is a rare disease, evidence regarding its impact on sleep and quality of life is limited; however, our study aims to evaluate this aspect.  \nPatients and Methods: In this case-control study, 72 patients with MF were enrolled in the case group, and 72 matched healthy individuals were enrolled in the control group. Data regarding sleep disturbances were collected and analyzed using the Pittsburgh Sleep Quality Index (PSQI) and Insomnia Severity Index (ISI) questionnaires. Poor sleep quality was defned as a score > 5. Results: Te control and case groups had median scores of 5.12 ± 2.57 and 10.22 ± 3.75 by PSQI and 6.39 ± 4.86 and 16.28 ± 6.99 by ISI, respectively. Multiple logistic regression revealed a signifcant association between the study group and the prevalence of poor sleep quality, as measured by both the PSQI (p \u003C 0.0001) and the ISI (p \u003C 0.0001) . However, age, sex, marital status, pruritus, disease stage and onset, and lesion locations were not found to be associated with poor sleep quality.  \nDiscussions: Both the severity and prevalence of sleep disorders were signifcantly higher in the patients compared to a matched healthy population. Due to the profound impact of sleep on quality of life and considering the high prevalence of sleep disorders inpatients with MF, evaluating a patient’s sleep quality could improve their quality of life. Terefore, professional treatment can be administered if sleep disorders are observed or suspected.  \nKeywords: ISI; mycosis fungoides; PSQI; sleep quality  \n1. Introduction  \nMycosis fungoides (MF) is the most common form of cutaneous T cell lymphoma (CTCL), accounting for approximately one-half of all CTCL cases [1] . Although MF most commonly afects the skin, lymph nodes, blood, and visceral organs may also be involved.  \nDisease etiology is yet to be discovered. Recent studies have proposed genetic predisposition and epigenetic factors [2, 3] . Skin lesions in the classic form of the disease include patches or plaques that may be localized or widespread, tumors, and erythroderma, which are usually seen in sunprotected parts of the patient’s body. Clinical and  \nhistopathological studies are usually used to make a diagnosis, but when the fndings are inconsistent, immunohistochemistry and molecular data are required to confrm the diagnosis [4–6] . MF is the most prevalent in individuals over the age of 50 [7–9] . Te incidence of the disease is higher in men than in women [7–10] .  \nSkin problems and sleep problems are closely related. Te skin plays an important role in sleep physiology by regulating body temperature and initiating sleep [11] . Meanwhile, skin-related symptoms such as itching and mental health issues may also interfere with sleep [12] . Accordin","cbCairJiZ3ZW7GJN","https://ap.wps.com/l/cbCairJiZ3ZW7GJN","pdf",532406,"English","# Introduction\n# Patients and Methods\n# Discussions\n# Keywords","[{\"question\":\"How many patients were included in the case and control groups?\",\"answer\":\"The case group included 72 patients with mycosis fungoides, and the control group included 72 matched healthy individuals.\"},{\"question\":\"Which questionnaires were used to evaluate sleep disturbances?\",\"answer\":\"Sleep quality and insomnia severity were assessed using the Pittsburgh Sleep Quality Index (PSQI) and the Insomnia Severity Index (ISI).\"},{\"question\":\"What was the main finding regarding sleep quality in MF patients?\",\"answer\":\"Both the prevalence and severity of sleep disorders were significantly higher in MF patients than in the matched healthy population.\"}]","Prevalence and Severity of Sleep Disorders in Patients With Mycosis Fungoides - A Case-Control Study | PDF",1790683196]