[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-400664-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-400664-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","prep-on-demand-how-to-take-prep-on-demand","PrEP-On-Demand - How to take PrEP \"On Demand\"","","PrEP \"On Demand\" provides guidance for following the 2-1-1 dosing schedule based on timing around anal sex. The material outlines when to take the first dose 2–24 hours (ideally 24 hours) before sex, the second dose 24 hours after the first dose, and subsequent doses at 48 hours and potentially 72 hours or later if sex occurs later than planned or occurs multiple times. It also advises switching to daily PrEP if sex is more than twice per week and continuing HIV testing every 3 months.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/prep-on-demand-how-to-take-prep-on-demand/400664/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/prep-on-demand-how-to-take-prep-on-demand/400664.png","ImageObject",300,407,{"name":42,"@type":43},"WPS_1790064749","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-27",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",9,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is the 2-1-1 dosing schedule for PrEP \"On Demand\"?","Question",{"text":63,"@type":64},"Take two tablets 2–24 hours (ideally 24 hours) before sex, then take 1 tablet 24 hours after the first dose and another 1 tablet 48 hours after the first dose.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What should you do if sex happens 24 hours later than planned?",{"text":68,"@type":64},"Take an additional tablet 72 hours after the first dose.",{"name":70,"@type":61,"acceptedAnswer":71},"When should someone switch from PrEP \"On Demand\" to daily PrEP, and what testing is still required?",{"text":72,"@type":64},"If sex is more than twice a week, take daily PrEP instead. HIV testing is still needed every 3 months.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},400664,1790694149,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":97,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":144,"preview_page_count":4},3985747859154,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","PrEP “On Demand”  \nExample: Fri 10 am  \n(Fri  \n10 pm)  \nSat  \n10 am  \nSun  \n10 am  \n-24 hours -2 hours 0 hour  \nFirst dose  \n24 hours after first dose  \nSecond dose  \n48 hours after first dose  \nThird dose  \nWhat if he cancels but we reschedule for the next day?  \nTake another pill.  \nExample: Fri 10 am Sat 10 am Sun 10 am Mon 10 am  \n(Fri night) (Sat night)  \n-24 hours -2 hours   \nFirst dose  \n24 hours after first dose  \nSecond dose  \n48 hours after first dose  \nThird dose  \n72 hours after first dose  \nFourth dose  \nWhat if it goes so well he comes back the next day (or  \nsomeone else)? Take another pill.  \nExample: Fri 10 am Sat 10 am Sun 10 am Mon 10 am  \n(Fri night) (Sat night)  \n-24 hours -2 hours  \nFirst dose  \n24 hours  \nafter first dose  \nSecond dose  \n48 hours after first dose  \nThird dose  \n72 hours after first dose  \nFourth dose  \nWhat if he (or someone else) keeps coming back for more?  \nTake daily PrEP.  \nExample: Fri 10 am Sat 10 am Sun 10 am Mon 10 am  \n(Fri night) (Sat night) (Sun night)  \nTue 10 am  \n-24 hours -2 hours  \nSex  \n24 hours after first dose  \nSecond dose  \n48 hours after first dose  \nThird dose  \n72 hours after first dose  \nFourth dose  \n96 hours after first dose  \nFifth dose  \nHow to take PrEP “On Demand”  \nHere is how you can follow the 2-1-1 dosing schedule of PrEP.  \n• PrEP “on demand’ is only approved for people who have anal sex.  \n• As a first dose, take two tablets 2-24 hours (ideally 24 hours) before sex.  \n• As a second dose, take 1 tablet 24 hours after the first dose.  \n• As a third dose, take 1 tablet 48 hours after the first dose.  \n• If you have sex 24 hours later than planned, take an additional tablet 72 hours after the first dose.  \n• If you have sex multiple times, keep on taking additional tablets until you have taken two tablets in the 48 hours (once every 24 hours) after your last sexual encounter.  \n• If you have sex more than twice a week, take daily PrEP instead.  \n• You still need HIV testing every 3 months.","cbCaicy5BGeOgG9Q","https://ap.wps.com/l/cbCaicy5BGeOgG9Q","pdf",294667,"English","# How to take PrEP \"On Demand\"\n## 2-1-1 dosing schedule overview\n## When sex timing changes and repeated encounters\n## When to take daily PrEP and continue HIV testing","[{\"question\":\"What is the 2-1-1 dosing schedule for PrEP \\\"On Demand\\\"?\",\"answer\":\"Take two tablets 2–24 hours (ideally 24 hours) before sex, then take 1 tablet 24 hours after the first dose and another 1 tablet 48 hours after the first dose.\"},{\"question\":\"What should you do if sex happens 24 hours later than planned?\",\"answer\":\"Take an additional tablet 72 hours after the first dose.\"},{\"question\":\"When should someone switch from PrEP \\\"On Demand\\\" to daily PrEP, and what testing is still required?\",\"answer\":\"If sex is more than twice a week, take daily PrEP instead. HIV testing is still needed every 3 months.\"}]","PrEP-On-Demand - How to take PrEP \"On Demand\" | PDF",1790513028,13]