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This observational, cross-sectional study compares premature ventricular contraction (PVC) prevalence and autonomic measures between 50 migraine patients and 51 matched healthy controls using 24-hour Holter monitoring. Migraine patients show higher sinus tachycardia prevalence and a positive correlation between PVC burden and MIDAS scores, while QTc and other major arrhythmic parameters do not differ significantly.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/premature-ventricular-complexes-and-migraine-insights-from-holter-monitoring-during-pain-free-intervals/438579/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/premature-ventricular-complexes-and-migraine-insights-from-holter-monitoring-during-pain-free-intervals/438579.png","ImageObject",300,407,{"name":92,"@type":93},"Finn","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-30","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the study objective regarding migraine and heart rhythm?","Question",{"text":112,"@type":113},"To assess the association between migraine and cardiac arrhythmias, focusing on the prevalence of premature ventricular contractions and autonomic dysfunction during pain-free periods.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was the study conducted and who participated?",{"text":117,"@type":113},"Fifty migraine patients and 51 age- and sex-matched healthy controls underwent 24-hour Holter monitoring plus standard electrocardiographic and echocardiographic evaluation.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the key findings about PVCs, sinus tachycardia, and QTc?",{"text":121,"@type":113},"At least one PVC occurred in 40% of migraine patients without a significant group difference, but sinus tachycardia was more prevalent in migraine. PVC burden correlated with MIDAS severity, while QTc intervals and other major arrhythmic parameters showed no significant differences.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},438579,1790740120,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":46},34359740700684,"https://ap-avatar.wpscdn.com/avatar/1f400023980c374ae676?_k=1777273430885731487","Article published online: 2025-12-08  \nOriginal Article 1  \nPremature ventricular complexes and migraine: insights from Holter monitoring during  \npain-free intervals  \nSerhat Kesriklioglu 1 Muhammed Fatih Kaleli 1 Yakup Alsancak 1 Aysenur Ince2 Mustafa Altas3  \n1 Necmettin Erbakan University, Faculty of Medicine, Department of Cardiology, Konya, Turkey.  \n2 Kelkit State Hospital, Department of Neurology, Gumushane, Turkey.  \n3 Necmettin Erbakan University, Faculty of Medicine, Department of Neurology, Konya, Turkey.  \nArq. Neuro-Psiquiatr. 2025;83(11):s00451813242 .  \nAddress for correspondence Serhat Kesriklioglu (email: [drserhatk@gmail.com](drserhatk@gmail.com))  \nAbstract  \nKeywords  \n► Migraine Disorders  \n► Ventricular Premature Complexes  \n► Autonomic Nervous System Diseases  \n► Electrocardiography, Ambulatory  \n► Tachycardia, Sinus  \nBackground Migraine is a common neurological disorder associated with an increased risk of cardiovascular conditions, including arrhythmias. Although autonomic dysfunction is considered a key mechanism linking migraine and cardiac abnormalities, its impact during pain-free intervals remains unclear.  \nObjective To investigate the association between migraine and cardiac arrhythmias, focusing on the prevalence of premature ventricular contractions (PVCs) and autonomic dysfunction during pain-free periods.  \nMethods A total of 50 migraine patients and 51 age- and sex-matched healthy controls were enrolled in the present observational, cross-sectional study. All participants underwent 24-hour Holter monitoring, standard electrocardiographic and echocardiographic evaluation. The frequencies of PVCs, PR interval, QT interval (QTc), heart rate variability, and sinus tachycardia prevalence were compared between groups. Migraine-related disability was assessed using the Migraine Disability Assessment Scale (MIDAS) and the Headache Impact Test-6 (HIT-6) .  \nResults At least 1 PVC was detected in 40% of migraine patients, although no significant difference was observed compared with controls (p > 0.05) . However, migraine patients showed a significantly higher prevalence of sinus tachycardia (p \u003C0.05) . Additionally, a positive correlation was found between PVC burden and MIDAS scores, suggesting a potential link between migraine severity and arrhythmia risk. No significant differences were observed in QTc intervals or other major arrhythmic parameters.  \nConclusion Migraine patients may exhibit increased sinus tachycardia and subtle electrocardiographic changes even during pain-free intervals, possibly reflecting underlying autonomic dysfunction.  \nreceived  \nMarch 13, 2025  \nreceived in its final form August 14, 2025  \naccepted  \nSeptember 3, 2025  \nDOI [https://doi.org/](https://doi.org/)[ ](https://doi.org/)10.1055/s-0045-1813242 . ISSN 0004-282X.  \nEditor-in-Chief: Hélio A. G. Teive.  \nAssociate Editor: Pedro Augusto Sampaio Rocha Filho.   \n© 2025 . The Author(s) .  \nThis is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit ([https://creativecommons.org/licenses/by/4.0/](https://creativecommons.org/licenses/by/4.0/))  \nThieme Revinter Publicações Ltda. , Rua Rego Freitas, 175, loja 1, República, São Paulo, SP, CEP 01220-010, Brazil  \n2 Premature ventricular complexes and migraine Kesriklioglu et al.  \nINTRODUCTION  \nMigraine is a prevalent and disabling neurological disorder, affecting> 1 billion people worldwide, with a particularly high prevalence among women \u003C50 years old. It is characterized by recurrent episodes of severe, unilateral headache often accompanied by autonomic symptoms such as nausea, vomiting, photophobia and phonophobia, which can markedly impair daily functioning.1–4 The pathophysiology of migraine is complex and multifactorial, involving genetic, behavioral, and environmental factors. These contribute to altered se","cbCaihCC9lcMSdnx","https://ap.wps.com/l/cbCaihCC9lcMSdnx","pdf",352606,"English","# Background\n# Objective\n# Methods\n# Results\n# Conclusion\n# Introduction","[{\"question\":\"What was the study objective regarding migraine and heart rhythm?\",\"answer\":\"To assess the association between migraine and cardiac arrhythmias, focusing on the prevalence of premature ventricular contractions and autonomic dysfunction during pain-free periods.\"},{\"question\":\"How was the study conducted and who participated?\",\"answer\":\"Fifty migraine patients and 51 age- and sex-matched healthy controls underwent 24-hour Holter monitoring plus standard electrocardiographic and echocardiographic evaluation.\"},{\"question\":\"What were the key findings about PVCs, sinus tachycardia, and QTc?\",\"answer\":\"At least one PVC occurred in 40% of migraine patients without a significant group difference, but sinus tachycardia was more prevalent in migraine. PVC burden correlated with MIDAS severity, while QTc intervals and other major arrhythmic parameters showed no significant differences.\"}]","Premature ventricular complexes and migraine - insights from Holter monitoring during pain-free intervals | PDF",1790685778]