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Outcomes were intended to inform future guidance for pregnancy and delivery management. The cohort included women from 2019–2021, with genotype characterization and pregnancy-related endpoints. No uterine rupture or life-threatening/fatal vascular events occurred in the perinatal period.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/pregnancy-and-delivery-outcomes-in-vascular-ehlersdanlos-syndrome-a-retrospective-multicentre-cohort-study/443371/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/pregnancy-and-delivery-outcomes-in-vascular-ehlersdanlos-syndrome-a-retrospective-multicentre-cohort-study/443371.png","ImageObject",300,407,{"name":92,"@type":93},"Asher","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-04","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",16,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What was the study’s primary objective?","Question",{"text":113,"@type":114},"To increase knowledge about pregnancy and delivery risks in vascular Ehlers–Danlos syndrome, and to support development of future guidelines for pregnancy and delivery management.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Which patients were included in the cohort?",{"text":118,"@type":114},"Women with vEDS due to pathogenic/likely pathogenic COL3A1 variants were included from 2019 until 2021.",{"name":120,"@type":111,"acceptedAnswer":121},"What were the key outcomes regarding severe vascular events and uterine rupture?",{"text":122,"@type":114},"In the perinatal period, neither uterine rupture nor life-threatening or fatal vascular events occurred in the cohort.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},443371,1791083551,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":46,"preview_page_count":4},687197207639,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","BJOG: An International Journal of Obstetrics & Gynaecology  \nRESEARCH ARTICLE  OPEN ACCESS   \nPregnancy and Delivery Outcomes in Vascular Ehlers–Danlos Syndrome: A Retrospective Multicentre Cohort Study  \nLisa M. van den Bersselaar1  | Ingrid M. B. H. van de Laar1 | Marieke J. H. Baars2,3 | Annette Baas4 | Eelco Dulfer5 | Apollonia T. J. M. Helderman-van den Enden6 | Yvonne Hilhorst-Hofstee7 | Robert M. Kauling8 | Marlies J. E. Kempers9 | Martijn A. Oudijk10,11  | Alessandra Maugeri2 | Hennie T. Brüggenwirth1 | Arjan C. Houweling2,3 | Serwet Demirdas1  \n1Department of Clinical Genetics, Erasmus MC, University Medical Center, Rotterdam, the Netherlands | 2Department of Human Genetics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands | 3Department of Human Genetics, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands | 4Department of Genetics, University Medical Center Utrecht, Utrecht, the Netherlands | 5Department of Genetics, University Medical Center Groningen, Groningen, the Netherlands | 6Clinical Genetics, Maastricht University Medical Center, Maastricht, the Netherlands | 7Department of Clinical Genetics, Leiden University Medical Center (LUMC), Leiden, the Netherlands | 8Department of Cardiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands | 9Department of Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands | 10Department of Obstetrics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands | 11Amsterdam Reproduction and Development Research Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands  \nCorrespondence: Serwet Demirdas ([s.demirdas@erasmusmc.nl](s.demirdas@erasmusmc.nl))  \nReceived: 5 December 2024 | Revised: 25 February 2025 | Accepted: 2 March 2025  \nFunding: The authors received no specific funding for this work.  \nKeywords: COL3A1 | delivery | pregnancy | type III collagen | vascular EDS | vEDS  \nABSTRACT  \nObjective: We aim to increase knowledge on pregnancy and delivery risks in vascular Ehlers–Danlos Syndrome (vEDS) . Our outcomes can contribute to establishing future guidelines for pregnancy and delivery management in women with vEDS. Design: Retrospective multicentre cohort study.  \nSetting: Women with vEDS due to pathogenic/likely pathogenic (P/LP) COL3A1 variants are at increased risk for arterial dissection and pregnancy-related complications during pregnancy and delivery.  \nPopulation: Women with a P/LP COL3A1 variant were included from 2019 until 2021.  \nMethods: Genetic and clinical data was collected through retrospective analysis.  \nMain Outcome Measures: Description of the genotype and pregnancy-related outcomes.  \nResults: We collected information about 121 pregnancies of 43 women with vEDS, including nine women with a haploinsufficient variant. Neither uterine rupture nor life-threatening or fatal vascular events occurred in the perinatal period. The miscarriage rate was 19%(23/121) and 19.1% of the live births were preterm (18/94) . Miscarriages were significantly more frequent in women with a glycine substitution in COL3A1 compared to other COL3A1 variant types (19/23, 82.6%, p = 0.018). Thirty-four women had a vaginal birth (79.1%), including 1/7 with known vEDS. Eight deliveries were complicated by severe perineal tears, and six by postpartum haemorrhage.  \n\n| Arjan C. Houweling and Serwet Demirdas contributed equally to this work. |\n| --- |\n| This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.\u003Cbr>© 2025 The Author(s). BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd. |\n\nBJOG: An International Journal of Obstetrics & Gynaecology, 2026; 133:463–470 463  \n[https://doi.o","cbCaigB1GjkXmpDT","https://ap.wps.com/l/cbCaigB1GjkXmpDT","pdf",306233,"English","# Introduction\n# Methods\n# Results\n# Conclusions","[{\"question\":\"What was the study’s primary objective?\",\"answer\":\"To increase knowledge about pregnancy and delivery risks in vascular Ehlers–Danlos syndrome, and to support development of future guidelines for pregnancy and delivery management.\"},{\"question\":\"Which patients were included in the cohort?\",\"answer\":\"Women with vEDS due to pathogenic/likely pathogenic COL3A1 variants were included from 2019 until 2021.\"},{\"question\":\"What were the key outcomes regarding severe vascular events and uterine rupture?\",\"answer\":\"In the perinatal period, neither uterine rupture nor life-threatening or fatal vascular events occurred in the cohort.\"}]","Pregnancy and Delivery Outcomes in Vascular Ehlers–Danlos Syndrome - A Retrospective Multicentre Cohort Study | PDF",1790703807]