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A secondary analysis used control-group participants from the SPRINTT trial, defining incident disability as failing a 400-meter walk within 15 minutes. From 759 participants, 354 developed disability over 26 months. Baseline 400 m walk time emerged as the strongest predictor; longer time, older age, lower SPPB, and higher CES-D and SARC-F increased risk.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/predictors-of-mobility-disability-in-older-adults-with-physical-frailty-and-sarcopenia-abstract/424666/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/predictors-of-mobility-disability-in-older-adults-with-physical-frailty-and-sarcopenia-abstract/424666.png","ImageObject",300,407,{"name":92,"@type":93},"Mafia Boss","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How was incident mobility disability defined in the study?","Question",{"text":112,"@type":113},"Incident mobility disability was defined as inability to complete a 400-meter walk test within 15 minutes.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which baseline measure was the strongest and most consistent predictor?",{"text":117,"@type":113},"Baseline 400-meter walk time was the strongest and most consistent predictor of mobility disability.",{"name":119,"@type":110,"acceptedAnswer":120},"How did depressive symptoms affect the relationship with walking time?",{"text":121,"@type":113},"Depressive symptoms modified the impact of walking time, with the highest risk among participants with both slow gait (≥480s) and CES-D ≥9.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},424666,1791170326,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":14,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":24,"preview_page_count":4},962090760730,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","1194 Innovation in Aging, 2025, Vol. 9, No. S2  \nAbstract citation ID: igaf122.3998  \nPREDICTORS OF MOBILITY DISABILITY IN OLDER ADULTS WITH PHYSICAL FRAILTY AND  \nSARCOPENIA  \nRiccardo Calvani1, Matteo Tosato1, Stefano Cacciatore2, Emanuele Marzetti1, and Francesco Landi1, 1. Università Cattolica del Sacro Cuore, Rome, Lazio, Italy, 2. Università  \nCattolica del Sacro Cuore, Rom, Lazio, Italy  \nOlder adults with physical frailty and sarcopenia (PF&S) face a high risk of mobility disability. Early identification of predictors is essential to develop targeted preventive strategies. We performed a secondary analysis of the SPRINTT trial (NCT02582138) including community-dwelling older adults with PF&S and preserved mobility at baseline. To avoid intervention-related confounding, only participants in the control group were analyzed. Incident mobility disability was defined as inability to complete a 400-meter walk test within 15 minutes. Eighty-eight baseline variables (demographic, clinical, functional, social, and laboratory) were tested as candidate predictors using  \nInnovation in Aging, 2025, Vol. 9, No. S2 1195  \nmultivariate classification methods and machine learning (Partial Least-Squares Discriminant Analysis [PLS-DA], Random Forest, Gradient Boosting) . Cox proportional hazards models were applied to confirm associations. Among 759 participants (71.3% women; median age 78 years), 354 (47%) developed mobility disability over 26 months. Model accuracy was similar across approaches (best PLS-DA: 67.6%) . Baseline 400 m walk time was the strongest and most consistent predictor. In multivariate Cox regression, longer walking time, older age, lower SPPB score, and higher CES-D and SARC-F scores were independently associated with disability risk. Notably, depressive symptoms modified the impact of walking time (interaction p \u003C 0.001):  \nparticipants with both slow gait (≥480s) and CES-D ≥9 had the highest risk (HR = 2.69; 95% CI: 1.89–3.84) . Kaplan–Meier curves confirmed the additive effect of gait speed and depression.  \nSlower gait and depressive symptoms independently and synergistically predict mobility disability in older adults with PF&S.  \nSimple cutoffs (400 m walk ≥480s, CES-D ≥9) may help identify high-risk individuals and inform preventive interventions.","cbCaio4OpyCUglBB","https://ap.wps.com/l/cbCaio4OpyCUglBB","pdf",2051762,"English","# Abstract\n## Study design\n## Outcome definition\n## Candidate predictors and modeling\n## Key findings\n## Clinical implications","[{\"question\":\"How was incident mobility disability defined in the study?\",\"answer\":\"Incident mobility disability was defined as inability to complete a 400-meter walk test within 15 minutes.\"},{\"question\":\"Which baseline measure was the strongest and most consistent predictor?\",\"answer\":\"Baseline 400-meter walk time was the strongest and most consistent predictor of mobility disability.\"},{\"question\":\"How did depressive symptoms affect the relationship with walking time?\",\"answer\":\"Depressive symptoms modified the impact of walking time, with the highest risk among participants with both slow gait (≥480s) and CES-D ≥9.\"}]","PREDICTORS OF MOBILITY DISABILITY IN OLDER ADULTS WITH PHYSICAL FRAILTY AND SARCOPENIA - Abstract | PDF",1790634985]