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The study evaluates mortality and ICU admission predictors and examines outcomes related to early versus late endoscopic retrograde cholangiopancreatography.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/predictors-of-intensive-care-unit-admission-rates-in-patients-with-acute-cholangitis/406227/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/predictors-of-intensive-care-unit-admission-rates-in-patients-with-acute-cholangitis/406227.png","ImageObject",300,407,{"name":42,"@type":43},"Fahsai","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-28",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",7,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What makes acute cholangitis clinically high risk even as overall mortality declines?","Question",{"text":63,"@type":64},"Severe acute cholangitis can still result in mortality around 10%–30% due to sepsis, multi-organ failure, and systemic inflammatory response syndrome.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Which factors are reported as predictors of poor outcomes in acute cholangitis?",{"text":68,"@type":64},"Reported predictors include older age, end-organ failure, multiple inflammatory and hematologic ratios, ventilator support need, diabetes, electrolyte imbalance, procalcitonin-to-albumin and C-reactive protein-to-albumin ratios, Glasgow Coma Scale, and systolic hypertension.",{"name":70,"@type":61,"acceptedAnswer":71},"How does early endoscopic retrograde cholangiopancreatography relate to outcomes?",{"text":72,"@type":64},"Early versus late ERCP is assessed for outcomes; early ERCP is associated with improved mortality and shorter hospital stay when performed within 24–72 hours, with no benefit in the first 24 hours.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},406227,1790740126,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,109,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":107,"slug":108},40,"healthcare",{"id":110,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},8,"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":55,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":102,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":144,"preview_page_count":4},549768702563,"https://ap-avatar.wpscdn.com/avatar/8000c4aa63b76e948b?x-image-process=image/resize,m_fixed,w_180,h_180&k=1786536092046926083","| W | J | C | C | World Journal of\u003Cbr>Clinical Cases |\n| --- | --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Clin Cases 2025 December 16; 13(35): 115090  \nDOI: 10.12998/wjcc.v13.i35.115090 ISSN 2307-8960 (online)  \nLETTER TO THE EDITOR  \nPredictors of intensive care unit admission rates in patients with acute cholangitis  \nHyder Osman Mirghani, Abdelwahab H Hussien  \nSpecialty type: Gastroenterology and Hepatology  \nProvenance and peer review:  \nInvited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s classification Scientific Quality: Grade B  \nNovelty: Grade A  \nCreativity or Innovation: Grade B  \nScientific Significance: Grade B  \nP-Reviewer: Bake JF, MD, Assistant Professor, Consultant, Congo  \nReceived: October 9, 2025  \nRevised: October 25, 2025  \nAccepted: December 3, 2025  \nPublished online: December 16, 2025  \nProcessing time: 69 Days and 22.1 Hours  \nHyder Osman Mirghani, Department of Internal Medicine, University of Tabuk, Tabuk 51941, Saudi Arabia  \nAbdelwahab H Hussien, Department of Internal Medicine, Faculty of Medicine, University of Tabuk, Tabuk 71491, Saudi Arabia  \nCorresponding author: Hyder Osman Mirghani, MD, Professor, Department of Internal Medicine, University of Tabuk, Prince Fahd Bin Sulta, Tabuk 51941, Saudi Arabia.  \n[s.hyder63@hotmail.com](s.hyder63@hotmail.com)  \nAbstract  \nAcute cholangitis (AC) is a heterogeneous disease with considerable variation in clinical presentation and high medical costs. Although the overall mortality rate is decreasing. However, the mortality in severe AC ranged from 10%-30% due to sepsis, multi-organ failure, and systemic inflammatory response syndrome. Assessing the predictors of poor outcomes, including mortality, intensive care unit (ICU) admission, and hospital stay, is vital for early and effective intervention. We assessed the predictors of mortality and ICU admission in patients with AC. We conducted a literature search in PubMed/MEDLINE, Google Scholar, and Cochrane Library for relevant articles. The keywords used were acute cholangitis, biliary cholangitis, predictors, mortality, ICU admission, and Hospital stay. In addition, we assessed the role of early vs late endoscopic retrograde cholangiopancreatography on the outcomes. Old age, end-organ failure, red cell distribution width to albumin ratio, neutrophil-to-lymphocyte ratio, platelet-lymphocyte ratio, the need for ventilator support, diabetes, electrolyte imbalance, procalcitonin-to-albumin ratio, C-reactive protein-to-albumin, Glasgow Coma Scale, and systolic hypertension are predictors of poor outcomes in AC of varying etiology, and concurrent acute pancreatitis was not associated with ICU admission.  \nKey Words: Acute cholangitis; Predictors; Intensive care unit admission; Mortality; Intensive care unit admission rates  \n©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.  \n WJCC  [https://www.wjgnet.com](https://www.wjgnet.com) 1 December 16, 2025  Volume 13  Issue 35   \nMirghani HO et al. AC and outcomes predictors  \nCore Tip: Acute cholangitis (AC) is the infection of the bile and bile ducts, usually resulting from obstruction by stones, benign strictures, and malignancies. AC is a heterogeneous disease with considerable variation in clinical presentation and high medical costs. Literature on AC prognosis is scarce, and studies investigating the indicators of admission to intensive care units are needed for the timely introduction of diagnostic measures and treatment. We gave an important insight regarding the independent predictors of mortality and intensive care unit admission.  \nCitation: Mirghani HO, Hussien AH. Predictors of intensive care unit admission rates in patients with acute cholangitis. World J Clin Cases 2025; 13(35): 115090  \nURL: [https://www.wjgnet.com/2307-8960/full/v13/i35/115090.htm](https://www.wjgnet.com/2307-8960/full/v13/i35/1","cbCaippe7WYWgu8i","https://ap.wps.com/l/cbCaippe7WYWgu8i","pdf",406995,"English","# Abstract\n# Core Tip\n# Citation","[{\"question\":\"What makes acute cholangitis clinically high risk even as overall mortality declines?\",\"answer\":\"Severe acute cholangitis can still result in mortality around 10%–30% due to sepsis, multi-organ failure, and systemic inflammatory response syndrome.\"},{\"question\":\"Which factors are reported as predictors of poor outcomes in acute cholangitis?\",\"answer\":\"Reported predictors include older age, end-organ failure, multiple inflammatory and hematologic ratios, ventilator support need, diabetes, electrolyte imbalance, procalcitonin-to-albumin and C-reactive protein-to-albumin ratios, Glasgow Coma Scale, and systolic hypertension.\"},{\"question\":\"How does early endoscopic retrograde cholangiopancreatography relate to outcomes?\",\"answer\":\"Early versus late ERCP is assessed for outcomes; early ERCP is associated with improved mortality and shorter hospital stay when performed within 24–72 hours, with no benefit in the first 24 hours.\"}]","Predictors of intensive care unit admission rates in patients with acute cholangitis | PDF",1790564272,15]