[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-455123-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-455123-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","predictive-value-of-serum-autotaxin-for-hepatocellular-carcinoma-recurrence-after-curative-radiofrequency-ablation","Predictive Value of Serum Autotaxin for Hepatocellular Carcinoma Recurrence After Curative Radiofrequency Ablation","","High recurrence rates of hepatocellular carcinoma (HCC) after curative therapy remain a major clinical problem. Autotaxin (ATX) is a biomarker in chronic liver disease, but its value in predicting HCC recurrence is not well defined. A retrospective study assessed whether precurative radiofrequency ablation (RFA) serum ATX levels could predict post-treatment recurrence in 56 curatively treated patients, evaluating diagnostic performance, survival differences, and hazard ratios.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/predictive-value-of-serum-autotaxin-for-hepatocellular-carcinoma-recurrence-after-curative-radiofrequency-ablation/455123/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/predictive-value-of-serum-autotaxin-for-hepatocellular-carcinoma-recurrence-after-curative-radiofrequency-ablation/455123.png","ImageObject",300,407,{"name":42,"@type":43},"Alexandar","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-30",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",9,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What question does the study address about autotaxin (ATX)?","Question",{"text":63,"@type":64},"It evaluates whether precurative RFA serum ATX levels can predict HCC recurrence after curative radiofrequency ablation.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were patients and recurrence outcomes analyzed?",{"text":68,"@type":64},"Fifty-six HCC patients treated by curative RFA were retrospectively analyzed, with recurrence assessed during follow-up using predictive performance metrics and survival analysis.",{"name":70,"@type":61,"acceptedAnswer":71},"What did the study find regarding ATX as a predictor after RFA?",{"text":72,"@type":64},"ATX showed superior predictive performance, and high ATX was associated with a significantly higher incidence of recurrence; multivariate analyses indicated ATX as an independent significant predictor.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},455123,1790937761,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":113,"preview_page_count":4},962090768658,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","Cancer Medicine  \n|  RESEARCH ARTICLE  OPEN ACCESS \u003Cbr>Predictive Value of Serum Autotaxin for Hepatocellular Carcinoma Recurrence After Curative Radiofrequency Ablation\u003Cbr>Takanobu Iwadare1 | Hiroyuki Kobayashi1 | Takefumi Kimura1,2,3  | Taiki Okumura1 | Taro Nakajima1 |\u003Cbr>Shun-ichi Wakabayashi1 | Yuki Yamashita1,2 | Naoyuki Fujimori3 | Hideo Kunimoto4 | Satoshi Shimamoto5 | Koji Igarashi5 | Takuro Uchida6,7  | Takeji Umemura8  | Naoki Tanaka9,10,11 \u003Cbr>1Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, Nagano, Japan | 2Consultation Center for Liver Diseases, Shinshu University Hospital, Nagano, Japan | 3Department of Hepatology, Shinshu Ueda Medical Center, Nagano, Japan | 4Department of Hepatology, Nagano Municipal Hospital, Nagano, Nagano, Japan | 5Bioscience Division, TOSOH Corporation, Ayase, Kanagawa, Japan | 6Division of Travel Medicine and Health, Research Center for GLOBAL and LOCAL Infectious Diseases, Oita University, Yufu, Oita, Japan | 7Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu, Oita, Japan | 8Shinshu University School of Medicine, Nagano, Japan | 9Department of Global Medical Research Promotion, Shinshu University Graduate School of Medicine, Nagano, Japan | 10International Relations Office, Shinshu\u003Cbr>University School of Medicine, Nagano, Japan | 11Research Center for Social Systems, Shinshu University, Nagano, Japan Correspondence: Takefumi Kimura ([kimuratakefumii@yahoo.co.jp](kimuratakefumii@yahoo.co.jp); [t_kimura@shinshu-u.ac.jp](t_kimura@shinshu-u.ac.jp))\u003Cbr>Received: 18 February 2025 | Revised: 2 June 2025 | Accepted: 17 December 2025\u003Cbr>Keywords: autotaxin | biomarker | hepatocellular carcinoma | radiofrequency ablation | recurrence |\n| --- |\n| \u003Cbr>ABSTRACT\u003Cbr>Background: Despite recent treatment advancements, the high recurrence rate of hepatocellular carcinoma (HCC) following curative therapy remains a significant challenge. Autotaxin (ATX) is a key biomarker in chronic liver disease that has a yet unclarified role in predicting HCC recurrence. This study examined whether precurative radiofrequency ablation (RFA) serum ATX level could serve as a predictor of HCC recurrence after treatment.\u003Cbr>Methods: Fifty-six HCC patients (37 [66%] male; median age: 74years) treated by curative RFA were retrospectively analyzed. Results: Twenty-one patients experienced HCC recurrence during follow-up. ATX demonstrated superior predictive performance for HCC recurrence after RFA, with an area under the receiver operating characteristic curve of 0.729, sensitivity of 0.857, and specificity of 0.629. Kaplan–Meier analysis revealed that patients with high ATX had a significantly higher incidence of HCC recurrence than those with low ATX (p = 0.0006) . In univariate analysis, the significant predictors of HCC recurrence included ATX (≥1.323 mg/L; hazard ratio [HR]: 6.49; 95% confidence interval [CI]: 1.90–22.13; p = 0.003), fibrosis-4 index (≥3.524; HR: 2.75; 95% CI: 1.00–7.55; p = 0.050), and mac-2 binding protein glycosylation isomer (≥3.85; HR: 2.12; 95% CI: 1.08–4.19; p = 0.030) . According to multivariate Cox proportional hazards analysis with seven different models adjusting for age and various established biomarkers, ATX consistently emerged as the only significant independent predictor of HCC recurrence, with HR values ranging from 6.38 to 10.50 (all p \u003C 0.05) . |\n| Abbreviations: 4C7S, type IV collagen 7S; AFP, alpha-fetoprotein; ALT, alanine aminotransferase; AST, aspartate aminotransferase; ATX, autotaxin; AUROC, area under the receiver operating characteristic curve; BMI, body mass index; CI, confidence interval; CT, computed tomography; ENPP2, ectonucleotide pyrophosphatase/ phosphodiesterase family member 2; FIB-4, fibrosis-4 index; HA, hyaluronic acid; HBV, hepatitis B virus; HCC, hepatocellular carcinoma; HCV, hepatitis C virus; HR, hazard ratio; IDR, intrahepatic distant recurrence; IQR, interquartile range; LPA,","cbCair8IbOPocQpi","https://ap.wps.com/l/cbCair8IbOPocQpi","pdf",1913874,12,"English","# Abstract\n## Introduction\n## Methods\n## Results\n## Conclusion","[{\"question\":\"What question does the study address about autotaxin (ATX)?\",\"answer\":\"It evaluates whether precurative RFA serum ATX levels can predict HCC recurrence after curative radiofrequency ablation.\"},{\"question\":\"How were patients and recurrence outcomes analyzed?\",\"answer\":\"Fifty-six HCC patients treated by curative RFA were retrospectively analyzed, with recurrence assessed during follow-up using predictive performance metrics and survival analysis.\"},{\"question\":\"What did the study find regarding ATX as a predictor after RFA?\",\"answer\":\"ATX showed superior predictive performance, and high ATX was associated with a significantly higher incidence of recurrence; multivariate analyses indicated ATX as an independent significant predictor.\"}]","Predictive Value of Serum Autotaxin for Hepatocellular Carcinoma Recurrence After Curative Radiofrequency Ablation | PDF",1790742171]