[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-338120-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-338120-en":131},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","predicted-25-hydroxyvitamin-d-over-the-adult-lifetime-and-the-risk-of-ovarian-cancer","Predicted 25-hydroxyvitamin D over the adult lifetime and the risk of ovarian cancer","","Evidence linking serum 25-hydroxyvitamin D (25(OH)D) to ovarian cancer risk remains inconclusive, partly because prior studies typically measured 25(OH)D late in adulthood, potentially missing etiologically relevant exposure windows. Using a population-based case-control study in Montreal, Canada (2011–2016; 490 cases, 896 controls), predicted 25(OH)D over adult life was estimated from validated regression models. Adjusted logistic regression and a weighted cumulative exposure (WCE) model assessed associations across time. Higher average predicted 25(OH)D showed an inverse association with ovarian cancer risk (aOR 0.73, 95% CI 0.55–0.96 per 20 nmol/L). WCE results suggested the strongest inverse associations for exposures 5–20 and 35–55 years prior to diagnosis.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/predicted-25-hydroxyvitamin-d-over-the-adult-lifetime-and-the-risk-of-ovarian-cancer/338120/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/predicted-25-hydroxyvitamin-d-over-the-adult-lifetime-and-the-risk-of-ovarian-cancer/338120.png","ImageObject",300,407,{"name":42,"@type":43},"Theodore","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-27","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",12,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Why was predicting 25(OH)D over the adult lifetime used in this study?","Question",{"text":63,"@type":64},"Prior evidence was inconclusive because serum 25(OH)D was often measured only in late adulthood, which may miss exposure periods relevant to ovarian cancer development. This study used predicted 25(OH)D across adulthood to better capture those windows.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What statistical approach estimated the association with ovarian cancer risk?",{"text":68,"@type":64},"Unconditional multivariable logistic regression models estimated adjusted odds ratios (aORs) and 95% confidence intervals for average predicted 25(OH)D over the adult lifetime. A weighted cumulative exposure (WCE) model explored relative importance across different past exposure periods.",{"name":70,"@type":61,"acceptedAnswer":71},"What were the main results for average and time-specific predicted 25(OH)D?",{"text":72,"@type":64},"For each 20 nmol/L increase in average predicted 25(OH)D over the adult lifetime, the aOR was 0.73 (95% CI 0.55–0.96). In WCE analyses, the inverse association was strongest for exposures 5–20 years and 35–55 years prior to diagnosis.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},338120,1790172146,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":116,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145},7971461740886,"https://ap-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","American Journal  of Epidemiology, 2024, 193, 1233–1241  \n[https://doi.org/10.1093/aje/kwae070](https://doi.org/10.1093/aje/kwae070)  \nAdvance access publication date May 17, 2024  \nOriginal Contribution  \nPredicted 25-hydroxyvitamin D over the adult lifetime and the risk of ovarian cancer  \nJennifer A. Ritonja†, 1 , 2 , 3 ,4  , Coraline Danieli†, 5 , 6  , Magnoudewa Priscille Pana1  , Michael J. Palmer1  , Kevin L’Espérance1 , 2  , Vikki Ho1 , 2  , Michal Abrahamowicz5 , 6  , Anita Koushik*, 1 , 2 , 3 ,4   \n1 Carrefour de l’innovation et de l’évaluation en santé, Université de Montréal Hospital Research Centre (CRCHUM), Montreal, QC H2X 0A9, Canada  \n2 Department of Social and Preventive Medicine, Université de Montréal, Montreal, QC H3N 1X9, Canada  \n3 Department of Oncology, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC H4A 3T2, Canada  \n4 St. Mary’s Research Centre, Montreal, QC H3T 0A2, Canada  \n5 Centre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3S5, Canada  \n6 Department of Epidemiology, Biostatistics and Occupational Health, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC H3A 1Y7, Canada  \n*Corresponding author: Anita Koushik, St. Mary’s Research Centre, 3777 Jean-Brillant Street, Montreal, QC H3T 0A2, Canada ([anita.koushik@mcgill.ca](anita.koushik@mcgill.ca))†J.A.R. and C.D. contributed equally to the conceptualization, analysis, and writing of this study and share co–first authorship.  \nAbstract  \nThe evidence from previous studies of serum 25-hydroxyvitamin D (25(OH)D) and ovarian cancer risk is not conclusive. However, the 25(OH)D levels were generally only measured in late adulthood, which may not capture the etiologically relevant exposure periods. We investigated predicted 25(OH)D over the adult lifetime in relation to ovarian cancer risk in a population-based case-control study conducted from 2011 to 2016 in Montreal, Canada (n = 490 cases and 896 controls) . Predicted 25(OH)D was computed using previously validated regression models. Unconditional multivariable logistic regression models were used to estimate adjusted odds ratios (aORs) and 95% CIs for average predicted 25(OH)D over the adult lifetime and ovarian cancer risk. In addition, the relative importance of different periods of past 25(OH)D exposure was explored using a weighted cumulative exposure (WCE) model. For each 20-nmol/L increase in average predicted 25(OH)D over the adult lifetime, the aOR (95% CI) was 0.73 (0.55-0.96) . In WCE analyses, the inverse association was strongest for exposures 5 to 20 years and 35 to 55 years prior to diagnosis, with aORs (95% CIs) of 0.82 (0.69-0.94) and 0.79 (0.66-1.02), respectively, for each 20-nmol/L increase in predicted 25(OH)D. These results support an inverse association between 25(OH)D levels in adulthood and ovarian cancer risk.  \nThis article is part of a Special Collection on Gynecological Cancers.  \nKey words: ovarian cancer; case-control studies; 25-hydroxyvitamin D; vitamin D; weighted cumulative exposure model.  \nOvarian cancer is the fifth-leading cause of cancer death among Canadian and US women, and is by far the deadliest of all gynecologic cancers.1 Unfortunately, in most cases, the disease has spread beyond the pelvis at diagnosis,1 reducing the longterm success of treatment,2 and currently available screening modalities do not reduce mortality.3 Prevention is thus of critical importance, which necessitates the identification of modifiable risk factors.  \nHigher vitamin D exposure, measured directly in serum or indirectly through its main sources of sunlight and diet, has been associated with reduced incidence and mortality for multiple cancers.4 Evidence from observational studies is strongest for colorectal cancer; associations with cancers of the breast, prostate, and ovary have been less consistent.4 Results from the Vitamin D and Omega-3 Trial (VITAL), a randomized","cbCairNt69cpTTNq","https://ap.wps.com/l/cbCairNt69cpTTNq","pdf",784232,"English","# Abstract\n## Study design and analysis\n## Main findings\n## Time-specific exposure patterns","[{\"question\":\"Why was predicting 25(OH)D over the adult lifetime used in this study?\",\"answer\":\"Prior evidence was inconclusive because serum 25(OH)D was often measured only in late adulthood, which may miss exposure periods relevant to ovarian cancer development. This study used predicted 25(OH)D across adulthood to better capture those windows.\"},{\"question\":\"What statistical approach estimated the association with ovarian cancer risk?\",\"answer\":\"Unconditional multivariable logistic regression models estimated adjusted odds ratios (aORs) and 95% confidence intervals for average predicted 25(OH)D over the adult lifetime. A weighted cumulative exposure (WCE) model explored relative importance across different past exposure periods.\"},{\"question\":\"What were the main results for average and time-specific predicted 25(OH)D?\",\"answer\":\"For each 20 nmol/L increase in average predicted 25(OH)D over the adult lifetime, the aOR was 0.73 (95% CI 0.55–0.96). In WCE analyses, the inverse association was strongest for exposures 5–20 years and 35–55 years prior to diagnosis.\"}]","Predicted 25-hydroxyvitamin D over the adult lifetime and the risk of ovarian cancer | PDF",1790022015,23]