[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-385322-105":59,"doc-detail-385322-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","prebiotics-ignored-player-in-the-fight-against-cancer","Prebiotics: Ignored player in the fight against cancer","","Background: Prebiotics is a relatively neglected area in cancer research, despite evidence suggesting that it plays a key role in suppressing tumour growth and improving immune function. Recent Findings: Including prebiotics in the diet strengthens the immune system and can slow down or prevent tumour growth. It also supports a healthy microbiome, improving cancer therapy effectiveness while reducing side effects. Conclusion: Mechanisms of inulin, FOS, β-glucan, pectin, and XOS are reviewed, including benefits during cancer therapy via improved gut health and reduced chemotherapy-associated damage.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/prebiotics-ignored-player-in-the-fight-against-cancer/385322/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/prebiotics-ignored-player-in-the-fight-against-cancer/385322.png","ImageObject",300,407,{"name":92,"@type":93},"Ben ","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-28","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why are prebiotics considered an overlooked area in cancer research?","Question",{"text":112,"@type":113},"The review notes that prebiotics are relatively neglected despite evidence linking them to suppressing tumour growth and improving immune function.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How can including prebiotics in the diet affect cancer outcomes?",{"text":117,"@type":113},"Dietary prebiotics are shown to strengthen the immune system and may slow down or prevent tumour growth, while supporting a healthy gut microbiome that improves treatment effectiveness and reduces side effects.",{"name":119,"@type":110,"acceptedAnswer":120},"Which prebiotic compounds and mechanisms are highlighted?",{"text":121,"@type":113},"The article highlights mechanisms involving inulin, fructooligosaccharide (FOS), β-glucan, pectin, and xylooligosaccharide (XOS), including effects on gut microbiota, short-chain fatty acids, and reduced gastrointestinal carcinogenic signals and pathogen adhesion.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},385322,1790464637,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":41},2336478951081,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","DOI: 10.1002/cnr2.1870  \nREVIE W  \nPrebiotics: Ignored player in the fight against cancer  \nParichita Mishra 1 | Vidhi Manish Badiyani 1 | Sakshi Jain 2 | Sruti Subramanian 2 | Sakshee Vinay Maharaj 2 | Ashwini Kumar 2 | Bhisham Narayan Singh 1   \n1Department of Ageing Research, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India 2Biotechnology and Bioinformatics Area, NIIT University, Neemrana, Rajasthan, India  \nCorrespondence  \nAshwini Kumar, Biotechnology and Bioinformatics Area, NIIT University, Neemrana, Rajasthan 301705, India.  \nEmail: [akbiomat@gmail.com](akbiomat@gmail.com)  \nBhisham Narayan Singh, Department of Ageing Research, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India. Email: [bhisham.singh@manipal.edu](bhisham.singh@manipal.edu)  \nAbstract  \nBackground: Prebiotics is a relatively neglected area in cancer research, despite evidence suggesting that it plays a key role in suppressing tumour growth and improving immune function.  \nRecent Findings: Including prebiotics in the diet has been shown to strengthen the immune system and can better slow down or prevent the growth of tumours. It has also been strongly indicated in various scientific studies that prebiotics can contribute to the sustenance of a healthy microbiome, which in turn plays an important role in increasing the effectiveness and reducing the side effects of cancer treatments. Conclusion: In the present review article we highlight the mechanisms by which prebiotics like inulin, fructooligosaccharide (FOS), β‐glucan, pectin, and xylooligosaccharide (XOS) function. Furthermore, the beneficial effect of incorporating prebiotics during cancer therapy to improvise gut health and prevent/reverse the damage caused to patients due to chemotherapy has also been elaborated.  \nKEYWOR DS  \ncancer, microbiome, prebiotics, tumour  \n1 | INTRODUCTION  \nCancer is a global health problem that has affected over 18.1 million people worldwide, as per a study conducted in 2020 .1 Age also plays a key role in cancer occurrence as the incidence increases significantly after 60 years of age, constituting more than 75% of the total affected population.2 However, it must be noted that children and adolescents are susceptible to some types of cancers, like retinoblastomas and bone cancers.2 Cancers can be broadly understood by checking a list of hallmarks that are acquired due to various factors such as—lifestyle, environment, genetic predisposition, and so on.3 These hallmarks were accurately summarised by the scientists Douglas Hanahan and Robert Weinberg and has been illustrated in Figure 1.  \nParichita Mishra, Vidhi Manish Badiyani and Sakshi Jain contributed equally.  \nOne of the many approaches taken by clinicians and scientists in designing treatment plans for patients with cancer has been to keenly study the tumour microenvironment. This has helped in understanding the pathophysiology of cancers, as not all progress at the same rate.3 Also, cancers are often caused by the accumulation of multiple mutations to oncogenes and tumour-suppressor genes.3 Treatment modalities for cancers span across a wide array of interdisciplinary fields. Some popular treatment options are chemotherapy, radiotherapy, surgery, and targeted therapy using monoclonal antibodies and small molecules.4 However, these treatment modalities are often plagued by dangerous side effects like peripheral neuropathy, anaemia, formation of edemas, hair loss, chronic fatigue, thrombocytopenia, and delirium, just to name a few.5 They can drastically affect the quality of life in patients, and thus, treatment using prebiotics has seen a surge in popularity. Prebiotics are fermented compounds and were introduced in 1995 by the scientists Glenn Gibson and Marcel Roberfroid.6  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproductio","cbCaicSjVujAusz6","https://ap.wps.com/l/cbCaicSjVujAusz6","pdf",2003941,12,"English","# Abstract\n# Introduction\n# Prebiotics and their health benefits","[{\"question\":\"Why are prebiotics considered an overlooked area in cancer research?\",\"answer\":\"The review notes that prebiotics are relatively neglected despite evidence linking them to suppressing tumour growth and improving immune function.\"},{\"question\":\"How can including prebiotics in the diet affect cancer outcomes?\",\"answer\":\"Dietary prebiotics are shown to strengthen the immune system and may slow down or prevent tumour growth, while supporting a healthy gut microbiome that improves treatment effectiveness and reduces side effects.\"},{\"question\":\"Which prebiotic compounds and mechanisms are highlighted?\",\"answer\":\"The article highlights mechanisms involving inulin, fructooligosaccharide (FOS), β-glucan, pectin, and xylooligosaccharide (XOS), including effects on gut microbiota, short-chain fatty acids, and reduced gastrointestinal carcinogenic signals and pathogen adhesion.\"}]","Prebiotics: Ignored player in the fight against cancer | PDF",1790267988]