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Among 134 positive cases, three had clinically significant pre-malignant conditions (ovarian mucinous cystadenoma, appendiceal mucinous neoplasm, and colon adenomas with high-grade dysplasia).",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/pre-malignant-conditions-diagnosed-following-a-positive-cancer-signal-from-a-multi-cancer-early-detection-test/329330/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/pre-malignant-conditions-diagnosed-following-a-positive-cancer-signal-from-a-multi-cancer-early-detection-test/329330.png","ImageObject",300,407,{"name":42,"@type":43},"Eden","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-05","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",11,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What did the DETECT-A study evaluate regarding multi-cancer early detection?","Question",{"text":63,"@type":64},"It assessed an MCED test, CancerSEEK, in 9,911 women aged 65–75 without a personal history of cancer, using a two-step testing approach before diagnostic evaluation when indicated.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were participants with positive MCED results further evaluated in this report?",{"text":68,"@type":64},"Participants with positive baseline and confirmatory MCED testing underwent 2-deoxy-2[18F]fluoro-D-glucose PET-CT and additional diagnostic workup guided by PET-CT results.",{"name":70,"@type":61,"acceptedAnswer":71},"What clinically significant pre-malignant conditions were identified?",{"text":72,"@type":64},"Three participants were found to have clinically significant pre-malignant conditions: ovarian mucinous cystadenoma, appendiceal mucinous neoplasm, and colon adenomas with high-grade dysplasia; 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Beer  \n [tbeer@exactsciences.com](tbeer@exactsciences.com)  \nRECEIVED 08 July 2024  \nACCEPTED 20 September 2024  \nPUBLISHED 25 October 2024  \nCITATION  \nChoudhry OA, Kharge AB, Rego SP, Elias PZ, Buchanan AH, Lennon AM, Papadopoulos N, Diehl F and Beer TM (2024) Pre-malignant conditions diagnosed following a positive cancer signal from a multi-cancer early detection test.  \nFront. Oncol. 14:1461693 .  \ndoi: 10.3389/fonc.2024.1461693  \nCOPYRIGHT  \n© 2024 Choudhry, Kharge, Rego, Elias, Buchanan, Lennon, Papadopoulos, Diehl and Beer. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nPre-malignant conditions diagnosed following a positive cancer signal from a multicancer early detection test  \nOmair A. Choudhry 1, Angana B. Kharge 1, Seema P. Rego 1, Paul Z. Elias 1, Adam H. Buchanan 2, Anne Marie Lennon 3, Nickolas Papadopoulos 4, Frank Diehl 1 and Tomasz M. Beer 1*  \n1 Exact Sciences Corporation, Madison, WI, United States, 2Geisinger, Danville, PA, United States,  \n3 Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States, 4School of Medicine, Johns Hopkins University, Baltimore, MD, United States  \nBlood-based tests for multi-cancer early detection (MCED) are being developed to facilitate the detection of various cancer types. The Detecting cancers Earlier Through Elective mutation-based blood Collection and Testing study (DETECT-A) study evaluated an MCED test in 9,911 women, age 65-75, without personal history of cancer. In a post-hoc analysis, we report on the detection of precancerous neoplasms consequent to MCED testing and follow-up. Participants with positive baseline and confirmatory MCED testing underwent 2-deoxy-2[fluorine-18]fluoro-D-glucose positron emission tomography-computed tomography (PETCT) and diagnostic evaluation as indicated by PET-CT results. We reviewed the electronic health records of participants with a precancerous neoplasm and summarized their clinical course. MCED results were positive in 134 participants. Clinically significant pre-malignant conditions were identified in three of these participants: A 71-year-old with an ovarian mucinous cystadenoma, a 67-year-old with an appendiceal mucinous neoplasm, and a 70-year-old with colon adenomas displaying high-grade dysplasia. All three participants underwent surgical treatment and remain alive and cancer-free as of last follow up. The diagnostic evaluation of a positive MCED test may occasionally reveal clinically significant precancerous conditions amenable to interventions. The frequency of such findingsand their clinical impact warrants further study.  \nKEYWORDS  \nmulti-cancer early detection, screening, early detection, CancerSEEK, DETECT-A, outcome  \nFrontiers in Oncology 01 [frontiersin.org](frontiersin.org)  \n1 Introduction  \nBlood-based MCED tests have the potential to detect multiple types of cancer, including uncommon cancers and those that lack standard-of-care screening options. Similar to standard-of-care cancer screening tests, a positive MCED test result provides a suspicion of cancer that requires a diagnostic evaluation to establish a definitive diagnosis. Several prospective studies investigating the clinical performance of MCED testing are underway. However, there are","cbCaiavcwiHHgTkw","https://ap.wps.com/l/cbCaiavcwiHHgTkw","pdf",1058329,"English","# Introduction\n## DETECT-A context and rationale\n# Methods\n## Study design and testing workflow\n## Diagnostic evaluation and eligibility","[{\"question\":\"What did the DETECT-A study evaluate regarding multi-cancer early detection?\",\"answer\":\"It assessed an MCED test, CancerSEEK, in 9,911 women aged 65–75 without a personal history of cancer, using a two-step testing approach before diagnostic evaluation when indicated.\"},{\"question\":\"How were participants with positive MCED results further evaluated in this report?\",\"answer\":\"Participants with positive baseline and confirmatory MCED testing underwent 2-deoxy-2[18F]fluoro-D-glucose PET-CT and additional diagnostic workup guided by PET-CT results.\"},{\"question\":\"What clinically significant pre-malignant conditions were identified?\",\"answer\":\"Three participants were found to have clinically significant pre-malignant conditions: ovarian mucinous cystadenoma, appendiceal mucinous neoplasm, and colon adenomas with high-grade dysplasia; all received surgical treatment and were alive and cancer-free at last follow-up.\"}]","Pre-malignant conditions diagnosed following a positive cancer signal from a multi-cancer early detection test | PDF",1789983696,15]