[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-385118-105":59,"doc-detail-385118-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","potential-role-of-intratumor-bacteria-outside-the-gastrointestinal-tract-more-than-passengers","Potential role of intratumor bacteria outside the gastrointestinal tract - More than passengers","","Tumor-associated bacteria and gut microbiota have drawn major attention for their potential roles in cancer initiation, progression, and therapeutic response. This review analyzes how intratumor bacteria outside the gastrointestinal tract contribute to tumorigenesis, metastasis, drug resistance, and anti-tumor immune modulation. It also summarizes detection methods, handling precautions for low-biomass samples, and advances in bacterial manipulation for tumor treatment, highlighting cancer-specific microbiome interactions and promising bacterial-based therapies.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/potential-role-of-intratumor-bacteria-outside-the-gastrointestinal-tract-more-than-passengers/385118/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/potential-role-of-intratumor-bacteria-outside-the-gastrointestinal-tract-more-than-passengers/385118.png","ImageObject",300,407,{"name":92,"@type":93},"Cart","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is the focus of this review on intratumor bacteria?","Question",{"text":113,"@type":114},"It discusses the contributions of intratumor bacteria outside the gastrointestinal tract, including mechanisms and implications for cancer therapy. It also covers functions of these bacteria within the tumor microenvironment.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How do intratumor bacteria relate to cancer hallmarks and tumor behavior?",{"text":118,"@type":114},"The review describes evidence that bacteria may influence many aspects of cancer hallmark acquisition and that intracellular bacteria can regulate tumor cell biological behavior. It also notes interactions between specific cancer types and their microbiomes.",{"name":120,"@type":111,"acceptedAnswer":121},"What methods and precautions are considered for studying low-biomass non-gastrointestinal tumor samples?",{"text":122,"@type":114},"The review summarizes techniques used to detect intratumor bacteria and emphasizes precautions required when handling low microbial biomass tumor samples. It also discusses strategies proposed to mitigate environmental contamination impacts.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},385118,1790464723,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},18829141979164,"https://eur-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","DOI: 10. 1002/cam4 .6298  \nREVIEW  \nPotential role of intratumor bacteria outside the gastrointestinal tract: More than passengers  \nZhu Liu | Lian-Lian Hong | Zhi-Qiang Ling  \nZhejiang Cancer Institute, Zhejiang Cancer Hospital, Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang, China  \nCorrespondence  \nZhi-Qiang Ling, Zhejiang Cancer Institute, Zhejiang Cancer Hospital, Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou 310022, Zhejiang, China.  \nEmail: [lingzq@zjcc.org.cn](lingzq@zjcc.org.cn)  \nFunding information  \nLeading Talents in Scientific and Technological Innovation from Zhejiang Provincial Ten Thousand Talents Plan, Grant/Award Number:  \nZhejiang Provincial CPC Committee Talents [2019]-3; Major Training Personnel from Zhejiang Provincial Program for Training and Development Project for 151 Talents, Grant/Award Number: Zjhrss2014-150; National Health Commission Science Research Fund-Zhejiang Provincial Health Key Science and Technology Plan Project, Grant/Award Number: WKJ-ZJ-2117; National Natural Science Foundation of China, Grant/Award Number:  \n81972908 and 32271238; Zhejiang Province Health Leader Talent, Grant/ Award Number: Zjwjw2021-40  \nAbstract  \nIntroduction: Tumor-associated bacteria and gut microbiota have gained significant attention in recent years due to their potential role in cancer development and therapeutic response. This review aims to discuss the contributions of intratumor bacteria outside the gastrointestinal tract, in addition to exploring the mechanisms, functions, and implications of these bacteria in cancer therapy. Methods: We reviewed current literature on intratumor bacteria and their impact on tumorigenesis, progression, metastasis, drug resistance, and anti-tumor immune modulation. Additionally, we examined techniques used to detect intratumor bacteria, precautions necessary when handling low microbial biomass tumor samples, and the recent progress in bacterial manipulation for tumor treatment.  \nResults: Research indicates that each type of cancer uniquely interacts with its microbiome, and bacteria can be detected even in non-gastrointestinal tumors with low bacterial abundance. Intracellular bacteria have the potential to regulate tumor cells' biological behavior and contribute to critical aspects of tumor development. Furthermore, bacterial-based anti-tumor therapies have shown promising results in cancer treatment.  \nConclusions: Understanding the complex interactions between intratumor bacteria and tumor cells could lead to the development of more precise cancer treatment strategies. Further research into non-gastrointestinal tumor-associated bacteria is needed to identify new therapeutic approaches and expand our knowledge of the microbiota's role in cancer biology.  \nKEYWORDS  \nbacterial-mediated cancer therapy, carcinogenesis, intracellular bacteria, intratumor bacteria, tumor microenvironment  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n© 2023 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.  \nLIU et al.  \n|  \n16757  \n1 | INTRODUCTION  \nCancer is caused by genetic changes that perpetuate malignancy.1,2 Recent data from investigations of host– microbe interactions suggest that microbiomes, particularly bacteria in tumors, may play a significant role in the acquisition of cancer hallmark capabilities,3 bringing the long-standing question of the relationship between cancer and bacteria back to the forefront.  \nHistorically, attempts to treat cancer with microorganisms were among the early strategies employed to combat the disease. The spontaneous regression of malignancies following bacterial infection has been observed since the 13th century.4,5 In the 19th century, Dr. William Coley treated tumors with intratumoral injecti","cbCailtedgHyOZyV","https://ap.wps.com/l/cbCailtedgHyOZyV","pdf",2808209,18,"English","# Abstract\n# Introduction\n## Historical background of bacterial antitumor approaches\n## Microbe–host interactions and cancer hallmarks\n## Expanding tumor-associated bacteria beyond the gut\n# Methods\n# Results\n# Conclusions","[{\"question\":\"What is the focus of this review on intratumor bacteria?\",\"answer\":\"It discusses the contributions of intratumor bacteria outside the gastrointestinal tract, including mechanisms and implications for cancer therapy. It also covers functions of these bacteria within the tumor microenvironment.\"},{\"question\":\"How do intratumor bacteria relate to cancer hallmarks and tumor behavior?\",\"answer\":\"The review describes evidence that bacteria may influence many aspects of cancer hallmark acquisition and that intracellular bacteria can regulate tumor cell biological behavior. It also notes interactions between specific cancer types and their microbiomes.\"},{\"question\":\"What methods and precautions are considered for studying low-biomass non-gastrointestinal tumor samples?\",\"answer\":\"The review summarizes techniques used to detect intratumor bacteria and emphasizes precautions required when handling low microbial biomass tumor samples. It also discusses strategies proposed to mitigate environmental contamination impacts.\"}]","Potential role of intratumor bacteria outside the gastrointestinal tract - More than passengers | PDF",1790266820,45]