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A retrospective cohort of 502 COP patients was assembled from the Taiwan National Poison Control Center from 2000 to 2015, with multivariate logistic regression used to determine risk factors. Cumulative incidences were 12.0% for DNS and 19.7% for MI, with early differentiation supporting appropriate evaluation and therapy.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/potential-risk-factors-for-delayed-neurological-sequelae-and-myocardial-injury-following-acute-carbon-monoxide-poisoning-retrospective-study/436155/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/potential-risk-factors-for-delayed-neurological-sequelae-and-myocardial-injury-following-acute-carbon-monoxide-poisoning-retrospective-study/436155.png","ImageObject",300,407,{"name":92,"@type":93},"Levi","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-04","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What long-term complications were evaluated after acute carbon monoxide poisoning?","Question",{"text":112,"@type":113},"The study focused on delayed neurological sequelae (DNS) and myocardial injury (MI), which may develop after the acute phase of poisoning.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How many COP patients were included and what timeframe did the data cover?",{"text":117,"@type":113},"The retrospective study enrolled 502 patients with complete data from the Taiwan National Poison Control Center between January 1, 2000, and December 31, 2015.",{"name":119,"@type":110,"acceptedAnswer":120},"Which indicators were identified as risk factors for DNS and for MI?",{"text":121,"@type":113},"DNS was associated with a Glasgow Coma Scale (GCS) score \u003C9 and rhabdomyolysis. MI risk increased with GCS \u003C9, rhabdomyolysis, acute renal impairment, and leukocytosis.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},436155,1790811483,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":46,"preview_page_count":4},7971461740909,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","J Chin MedAssoc  \nOriginal article  \nPotential risk factors for delayed neurological sequelae and myocardial injury following acute carbon monoxide poisoning: A retrospective study  \nMin-Po Hoa, Yuan-Hui Wua,b, Tsan-Chi Chenc, Kuang-Chau Tsaia, Chen-Chang Yangd,e,f,*  \naDepartment of Emergency Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan, ROC; bSchool of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan, ROC; cDepartment of Medical Research, Far Eastern Memorial Hospital, New Taipei City, Taiwan, ROC; dSchool of Medicine, College of Medicine, National YangMing Chiao Tung University, Taipei, Taiwan, ROC; eInstitute of Environmental and Occupational Health Sciences, National YangMing Chiao Tung University School of Medicine, Taipei, Taiwan, ROC; fDepartment of Occupational Medicine and Clinical Toxicology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC  \nAbstract  \nBackground: Acute carbon monoxide poisoning (COP) has been a common cause of emergency hospital visits over the past decade. Besides the immediate symptoms of poisoning, carbon monoxide exposure can cause various long-term complications, especially delayed neurological sequelae (DNS) and myocardial injury (MI) .  \nMethods: This study retrospectively enrolled 502 patients with COP, including complete collection data, from the Taiwan National Poison Control Center between January 1, 2000, and December 31, 2015. After collecting the relevant clinical and laboratory data, multivariate logistic regression analysis was performed to identify significant risk factors, hazard ratio (HR), and confidence intervals (CI) .  \nResults: The cumulative incidence was 12.0% and 19.7% for DNS and MI, respectively. A Glasgow Coma Scale (GCS) score of \u003C9 (OR, 2.55; 95% CI, 1.52-4.27) and rhabdomyolysis (OR, 2.68; 95% CI, 1.59-4.53) were identified as individual indicators of DNS in patients with COP. However, a greater risk for MI was associated with a GCS score of \u003C9 (OR, 2.50; 95% CI, 1.67-3.74), rhabdomyolysis (OR, 4.91; 95% CI, 3.28-7.35), acute renal impairment (OR, 2.43; 95% CI, 1.59-3.71), and leukocytosis (OR, 9.55; 95% CI, 3 .88-23.50) . Hyperbaric oxygen therapy for patients with COP was more beneficial for DNS (OR, 0.64; 95% CI, 0.34-1.20) than for MI (OR, 1.94; 95% CI, 0.94-4.01) .  \nConclusion: Early differentiation of risk factors for DNS and MI contributes to an effective evaluation of patients with acute COP and the provision of appropriate therapy.  \nKeywords: Carbon monoxide poisoning; Delayed neurological sequelae; Myocardial injury; Rhabdomyolysis  \n1. INTRODUCTION  \nCarbon monoxide poisoning (COP) is a significant health concern that induces a range of neurological symptoms and can potentially be a fatal intoxication because carbon monoxide is a colorless, odorless, and nonirritating gas.1 Incomplete combustion of organic matter produces more carbon monoxide, making it the most common form of suicide.2,3 Due to physiological properties, the high permeability of carbon monoxide in the  \n*Address correspondence. Dr. Chen-Chang Yang, Institute of Environmental and Occupational Health Sciences, National YangMing University School of Medicine, 155, Section 2, Linong Street, Taipei 112, Taiwan, ROC. E-mail address: ccyang@ [vghtpe.gov.tw](vghtpe.gov.tw); [ccyang2@ym.edu.tw](ccyang2@ym.edu.tw) (C.-C. Yang).  \nAuthor contributions: Dr. Min-Po Ho and Dr. Yuan-Hui Wu contributed equally to this study.  \nConflicts of interest: The authors declare that they have no conflicts of interest related to the subject matter or materials discussed in this article.  \nJournal of Chinese Medical Association. (2025) 88: 330-337.  \nReceived June 18, 2024; accepted November 8, 2024. doi: 10. 1097/JCMA.0000000000001208  \nCopyright © 2025, the Chinese Medical Association. This is an open access article under the CC BY-NC-ND license ([http://creativecommons.org/licenses/](http://creativecommons.org/licenses/)[ ](http://creativecommons.org/licenses/)[by-nc-nd/4","cbCaivii1QzS4a4b","https://ap.wps.com/l/cbCaivii1QzS4a4b","pdf",450820,"English","# INTRODUCTION\n# METHODS\n# RESULTS\n# CONCLUSION\n# Keywords","[{\"question\":\"What long-term complications were evaluated after acute carbon monoxide poisoning?\",\"answer\":\"The study focused on delayed neurological sequelae (DNS) and myocardial injury (MI), which may develop after the acute phase of poisoning.\"},{\"question\":\"How many COP patients were included and what timeframe did the data cover?\",\"answer\":\"The retrospective study enrolled 502 patients with complete data from the Taiwan National Poison Control Center between January 1, 2000, and December 31, 2015.\"},{\"question\":\"Which indicators were identified as risk factors for DNS and for MI?\",\"answer\":\"DNS was associated with a Glasgow Coma Scale (GCS) score \\u003c9 and rhabdomyolysis. MI risk increased with GCS \\u003c9, rhabdomyolysis, acute renal impairment, and leukocytosis.\"}]","Potential risk factors for delayed neurological sequelae and myocardial injury following acute carbon monoxide poisoning - retrospective study | PDF",1790676967]