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This review summarizes their progress over the last two decades and links anticolitis potential to modulation of gut microflora and gut barrier function, inflammatory responses, oxidative stress, and apoptosis.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/potential-of-natural-flavonols-and-flavanones-in-the-treatment-of-ulcerative-colitis/376606/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/potential-of-natural-flavonols-and-flavanones-in-the-treatment-of-ulcerative-colitis/376606.png","ImageObject",300,407,{"name":42,"@type":43},"Himbo","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-24",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",13,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Why is ulcerative colitis difficult to treat, and what risks does it carry?","Question",{"text":63,"@type":64},"Ulcerative colitis is characterized by chronic, persistent, recurrent intestinal ulceration and commonly presents with abdominal pain, diarrhea, and bloody stools. It is difficult to cure and can carry a risk of canceration.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What limitations are mentioned for conventional ulcerative colitis therapies?",{"text":68,"@type":64},"Conventional treatments such as aminosalicylic acids, glucocorticoids, immunosuppressors, and biological agents have certain limitations and serious side effects.",{"name":70,"@type":61,"acceptedAnswer":71},"How do natural flavonols and flavanones potentially help in ulcerative colitis?",{"text":72,"@type":64},"Their potential is associated with modulation of gut microflora and gut barrier function, along with effects on inflammatory reactions, oxidative stress, and apoptosis.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},376606,1790275969,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":140,"language":141,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":12,"update_tm":145,"read_time":146},687197100911,"https://ap-avatar.wpscdn.com/avatar/a000239b6f1da00475?x-image-process=image/resize,m_fixed,w_180,h_180&k=1785132997149421697","TYPE Review  \nPUBLISHED 03 March 2023  \nDOI 10.3389/fphar.2023.1120616  \nOPEN ACCESS  \nEDITED BY  \nThomas Brzozowski,  \nJagiellonian University Medical College, Poland  \nREVIEWED BY  \nZhang Qing-Gao, Dalian University, China Silvia Speca,  \nInserm U1286 INFINITE, France Anella Saviano,  \nUniversity of Naples Federico II, Italy  \n*CORRESPONDENCE  \nQiang Lu,  \n [luqiang@zmu.edu.cn](luqiang@zmu.edu.cn)  \nSPECIALTY SECTION  \nThis article was submitted to Gastrointestinal and Hepatic Pharmacology,  \na section of the journal Frontiers in Pharmacology  \nRECEIVED 10 December 2022  \nACCEPTED 15 February 2023  \nPUBLISHED 03 March 2023  \nCITATION  \nLi C, Tang Y, Ye Y, Zuo M and Lu Q (2023), Potential of natural flavonols and flavanones in the treatment of ulcerative colitis.  \nFront. Pharmacol. 14:1120616 .  \ndoi: 10.3389/fphar.2023.1120616  \nCOPYRIGHT  \n© 2023 Li, Tang, Ye, Zuo and Lu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nPotential of natural flavonols and flavanones in the treatment of ulcerative colitis  \nCailan Li 1,2,3, Ying Tang 1,2,3, Yonghao Ye 4, Manhua Zuo 5 and Qiang Lu 6*  \n1Department of Pharmacology, Zunyi Medical University, Zhuhai Campus, Zhuhai, China, 2Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, China, 3Key Laboratory of Basic Pharmacology of Guizhou Province and School of Pharmacy, Zunyi Medical University, Zunyi, China, 4Zhuhai Resproly Pharmaceutical Technology Company Limited, Zhuhai, China, 5Department of Nursing, Zunyi Medical University, Zhuhai Campus, Zhuhai, China, 6Department of Pharmaceutical Sciences, Zunyi Medical University, Zhuhai Campus, Zhuhai, China  \nUlcerative colitis (UC) is an inflammatory bowel disease generally characterized by chronic, persistent, recurrent, and non-specific ulcers of the intestine. Its main clinical manifestations include abdominal pain, diarrhea, and bloody stools. This disease is difficult to cure and even carries the risk of canceration. It has been listed as a modern refractory disease by the World Health Organization. Though a large amount of drugs are available for the inhibition of UC, the conventional treatment such as aminosalicylic acids, glucocorticoids, immunosuppressors, and biological agents possess certain limitations and serious side effects. Therefore, it is urgently needed for safe and effective drugs of UC, and natural-derived flavonols and flavanones showed tremendous potential. The present study concentrated on the progress of natural-derived flavonols and flavanones from edible and pharmaceutical plants for the remedy of UC over the last two decades. The potential pharmaceutical of natural-derived flavonols and flavanones against UC were closely connected with the modulation of gut microflora, gut barrier  \nAbbreviations: AA acetic acid; Akt protein kinase B; ALP alkaline phosphatase; AMPK AMP-activated protein kinase; AP alkaline phosphatase; Bcl-2 B-cell lymphoma 2; BMDMs bone marrow-derived macrophages; CAT catalase; Cl cleaved; COX-2 cyclooxygenase 2; CXCL1 chemokine (C-X-C motif) ligand 1; DAI disease activity index; DNMT-1 DNA methyltransferase 1; DSS dextran sodium sulfate; ERK extracellular signal-regulated protein kinase; Foxp3 forkhead box P3; Gli1 Glioblastoma-1; GM-CSF granulocyte macrophage-colony stimulating factor; GSH glutathione; GSK-3β glycogen synthase kinase-3β; HMGB1 high mobility group box protein 1; HO-1 heme oxygenase-1; ICAM-1 intercellular adhesion molecule-1; Ig immunoglobulin; IκBα inhibitor κBα; IL ","cbCaiizONqMkEy6z","https://ap.wps.com/l/cbCaiizONqMkEy6z","pdf",1648847,15,"English","# Introduction\n# Potential mechanisms of natural flavonols and flavanones in ulcerative colitis\n## Gut microflora modulation\n## Gut barrier function\n## Inflammatory reactions, oxidative stress, and apoptosis","[{\"question\":\"Why is ulcerative colitis difficult to treat, and what risks does it carry?\",\"answer\":\"Ulcerative colitis is characterized by chronic, persistent, recurrent intestinal ulceration and commonly presents with abdominal pain, diarrhea, and bloody stools. It is difficult to cure and can carry a risk of canceration.\"},{\"question\":\"What limitations are mentioned for conventional ulcerative colitis therapies?\",\"answer\":\"Conventional treatments such as aminosalicylic acids, glucocorticoids, immunosuppressors, and biological agents have certain limitations and serious side effects.\"},{\"question\":\"How do natural flavonols and flavanones potentially help in ulcerative colitis?\",\"answer\":\"Their potential is associated with modulation of gut microflora and gut barrier function, along with effects on inflammatory reactions, oxidative stress, and apoptosis.\"}]","Potential of natural flavonols and flavanones in the treatment of ulcerative colitis | PDF",1790220199,38]