[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-378863-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-378863-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","potential-effects-of-geraniol-on-cancer-and-inflammation-related-diseases-a-review-of-the-recent-research-findings","Potential Effects of Geraniol on Cancer and Inflammation-Related Diseases - A Review of the Recent Research Findings","","Geraniol (GNL) is a natural monoterpene present in many essential oils and medicinal aromatic plants. It is widely used in cosmetics and food and shows broad pharmacological activity, including anti-inflammatory, anticancer, antimicrobial, antioxidant, and neuroprotective effects. Evidence indicates chemopreventive potential across multiple cancers, free-radical scavenging, preserved antioxidant-enzyme function, apoptosis induction, cell-cycle arrest, and modulation of targets such as p53 and STAT3. GNL benefits multiple animal and tumor-cell models with low toxicity, yet no clinical studies have been conducted. This review synthesizes updated findings on mechanisms, molecular targets, involved pathways, and therapeutic prospects.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/potential-effects-of-geraniol-on-cancer-and-inflammation-related-diseases-a-review-of-the-recent-research-findings/378863/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/potential-effects-of-geraniol-on-cancer-and-inflammation-related-diseases-a-review-of-the-recent-research-findings/378863.png","ImageObject",300,407,{"name":42,"@type":43},"Theodore","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-01","2026-09-24",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",7,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Geraniol有哪些已被提出的药理作用？","Question",{"text":63,"@type":64},"文中指出Geraniol具有抗炎、抗癌、抗菌、抗氧化和神经保护等多种药理活性，并可清除自由基、维持抗氧化酶活性。","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Geraniol对癌症可能通过哪些机制发挥作用？",{"text":68,"@type":64},"文中提到其可诱导凋亡与细胞周期阻滞，并调控多种分子靶点（如p53和STAT3）、激活caspases，同时通过转录调控影响炎症相关过程。",{"name":70,"@type":61,"acceptedAnswer":71},"目前Geraniol是否有临床研究证据？",{"text":72,"@type":64},"文中明确指出，已在动物模型和肿瘤细胞系中显示有效性，但尚未开展相关临床研究。","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},378863,1790485698,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,109,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":107,"slug":108},40,"healthcare",{"id":110,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},8,"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":55,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145},7971461740886,"https://ap-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","molecules   \nReview  \nPotential Effects of Geraniol on Cancer and Inflammation-Related Diseases: A Review of the Recent Research Findings  \nRebai Ben Ammar 1,2  \nCitation: Ben Ammar, R. Potential Effects of Geraniol on Cancer and Inflammation-Related Diseases: AReview of the Recent Research Findings. Molecules 2023, 28, 3669 . [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)molecules28093669  \nAcademic Editors: Mejdi Snoussi and Adel Kadri  \nReceived: 5 March 2023  \nRevised: 1 April 2023  \nAccepted: 17 April 2023  \nPublished: 23 April 2023  \nCopyright: © 2023 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Department of Biological Sciences, College of Science, King Faisal University, Al-Ahsa 31982, Saudi Arabia; [rbenammar@kfu.edu.sa](rbenammar@kfu.edu.sa); Tel.: +966-0135899429  \n2 Laboratory of Aromatic and Medicinal Plants, Center of Biotechnology of Borj-Cedria, Technopole of Borj-Cedria, P.O. Box 901, Hammam-Lif 2050, Tunisia  \nAbstract: Geraniol (GNL), a natural monoterpene, is found in many essential oils of fruits, vegetables, and herbs, including lavender, citronella, lemongrass, and other medicinal and aromatic plants. GNL is commonly used by the cosmetic and food industries and has shown a wide spectrum of pharmacological activities including anti-inflammatory, anticancer, antimicrobial, antioxidant, and neuroprotective activities. It represents a potential anti-inflammatory agent and a promising cancer chemopreventive agent, as it has been found tobe effective against a broad range of cancers, including colon, prostate, breast, lung, skin, kidney, liver, and pancreatic cancer. Moreover, GNL scavenges free radicals and preserves the activity of antioxidant enzymes. In addition, GNL induces apoptosis and cell cycle arrest, modulates multiple molecular targets, including p53 and STAT3, activates caspases, and modulates inflammation via transcriptional regulation. In the present study, different modes of action are described for GNL's activity against cancer and inflammatory diseases. This compound protects various antioxidant enzymes, such as catalase, glutathione-S-transferase, and glutathione peroxidase. Experiments using allergic encephalomyelitis, diabetes, asthma, and carcinogenesis models showed that GNL treatment had beneficial effects with low toxicity. GNL has been shown to be effective in animal models and tumor cell lines, but there have not been any clinical studies carried out for it. The aim of the present review is to provide updated data on the potential effects of GNL on cancer and inflammation, and to enhance our understanding of molecular targets, involved pathways, and the possible use of GNL for clinical studies and therapeutic purposes in the treatment of cancer and inflammation-related diseases.  \nKeywords: geraniol; antioxidant; inflammation diseases; anticancer; chemo preventive effects; molecular targets  \n1. Introduction  \nRecently, molecules from natural products are gaining acceptance as potentially promising complementary and alternative medicines for the treatment of various diseases [1–7] . Generally, pure compounds could target proteins, DNA, mRNA, and even microRNA. Studies suggest that monoterpenes might offer new chemotherapy strategies for cancer and inflammatory diseases [8–11], and accumulating evidence in the last decades has indicated that GNL is a pure botanical compound without adverse effects, exerting diverse pharmacological activities by mainly regulating protein expression. The acyclic monoterpene geraniol ((2E)-3,7-dimethylocta-2,6-dien-1-ol) is frequently found in the essential oils of many plant species (Figure 1) . Lemongrass, rose, lavender, and other arom","cbCaiue8fAj7HZuf","https://ap.wps.com/l/cbCaiue8fAj7HZuf","pdf",1782885,14,"English","# Abstract\n# 1. Introduction\n# 2. Potential anti-cancer effects of geraniol\n## Apoptosis induction and cell-cycle arrest\n## Signaling pathways and molecular targets","[{\"question\":\"Geraniol有哪些已被提出的药理作用？\",\"answer\":\"文中指出Geraniol具有抗炎、抗癌、抗菌、抗氧化和神经保护等多种药理活性，并可清除自由基、维持抗氧化酶活性。\"},{\"question\":\"Geraniol对癌症可能通过哪些机制发挥作用？\",\"answer\":\"文中提到其可诱导凋亡与细胞周期阻滞，并调控多种分子靶点（如p53和STAT3）、激活caspases，同时通过转录调控影响炎症相关过程。\"},{\"question\":\"目前Geraniol是否有临床研究证据？\",\"answer\":\"文中明确指出，已在动物模型和肿瘤细胞系中显示有效性，但尚未开展相关临床研究。\"}]","Potential Effects of Geraniol on Cancer and Inflammation-Related Diseases - A Review of the Recent Research Findings | PDF",1790232909,35]