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MicroRNAs (miRNAs) are small, single-stranded non-coding RNAs involved in post-transcriptional control of oncogene expression. Cancer tissues contain miRNAs that can influence cancer initiation and suppression. Dysregulated miRNAs occur across malignancies, and their stability in tissues and biological fluids supports detection. Evidence from many studies indicates higher diagnostic efficiency for distinguishing patients from healthy individuals. Identified miRNA signatures in blood underpin this review’s focus on early diagnosis, prognosis, and treatment evaluation.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/potential-diagnostic-utility-of-micrornas-in-gastrointestinal-cancers-review/379169/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/potential-diagnostic-utility-of-micrornas-in-gastrointestinal-cancers-review/379169.png","ImageObject",300,407,{"name":92,"@type":93},"นรินทร์","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Why is early detection important for gastrointestinal cancers?","Question",{"text":113,"@type":114},"Early diagnosis and careful monitoring reduce disease consequences and related mortality. 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MiRNAs have been shown to be potential cancer biomarkers that can be used to diagnose cancers. MiRNAs are single-stranded, small non-coding RNAs that are involved in the post-transcriptional regulation of the expression of different oncogenes. Cancer tissues contain miRNAs that playa special role in the etiology of cancer development or limiting cancer suppression. Dysregulation of miRNAs occurs in a variety of malignancies, including gastrointestinal cancers. MiRNAs are stable and protected against degradation by RNase, which enables their detection in tissues and biological fluids. The results of many studies suggest that miRNAs have a relatively higher diagnostic efficiency in distinguishing cancer patients from healthy people. The researchers have identified many miRNA signature in the blood for the detection of gastrointestinal cancers. This review focuses on the role and potential utility of miRNAs in the early detection, prognosis and evaluation of the treatment effectiveness of gastrointestinal cancers.\u003Cbr>Keywords: miRNA, gastric cancer, colorectal cancer, esophageal cancer, diagnosis |\n| --- |\n| Introduction\u003Cbr>Early diagnosis and careful monitoring of tumor development is a prerequisite for reducing the consequences of the disease and reducing the number of deaths, and to improve management cancer patients. The most important features of early tumor detection markers are the highest sensitivity and specificity. Recent research to identify tumors based on biomarkers in the blood has led to the identification a wide variety of cancer-related molecules. In recent years, microRNAs (miRNAs) have been shown to be effective candidates for the molecular diagnosis of many cancers.\u003Cbr>MiRNAs are endogenous small molecule single-chain non-coding regulatory RNAs with a length of 17–25 nucleotides that play a crucial role in post-transcriptional gene regulation. There are currently about 30,000 entries in the miR Registry Database, which means over forty thousand mature miRNA products, and their number may increase significantly in an exponential manner in the coming years. Non-coding RNA includes all RNA chains that are not translated into proteins. They are classified based on structure and length and include miRNAs, long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) . These different classes of ncRNAs play important roles in intricate networks of interaction with each other, miRNAs and various signaling pathways to effect changes in cells, surrounding tissues and entire organ systems. MiRNAs have highly conservative, temporal and tissue-specific characteristics. The biogenesis of miRNAs begins with their transcription from miRNA genes in the nucleus, transcripted into pri-miRNAs by RNA polymerase II. The resulting pri-miRNAs is then processed into pre-miRNA by the RNase III enzyme Drosha and its dsRNA-binding domain (dsRBD), DGCR8. Next, the mature miRNAs can arise from the stem of the pre-miRNA by the Dicer after be exported to the cytoplasm by XPO5 .1 Numerous studies have proven that miRNAs regulate over 30% of human genes, where one miRNA controls several hundred RNAs. Approximately 30–60% of all human proteins can be targeted via miRNAs that play a role in various cell d","cbCainysrc7Y8I56","https://ap.wps.com/l/cbCainysrc7Y8I56","pdf",1182457,"English","# Introduction\n## MicroRNAs in cancer diagnosis\n## Biogenesis and regulatory functions","[{\"question\":\"Why is early detection important for gastrointestinal cancers?\",\"answer\":\"Early diagnosis and careful monitoring reduce disease consequences and related mortality. It supports better management of cancer patients.\"},{\"question\":\"What makes microRNAs useful as diagnostic biomarkers?\",\"answer\":\"miRNAs are small, stable, and protected from degradation by RNase, allowing detection in tissues and biological fluids. Studies show their diagnostic efficiency in distinguishing patients from healthy people.\"},{\"question\":\"What role do miRNAs play in gene regulation and cancer development?\",\"answer\":\"miRNAs regulate post-transcriptional gene expression and can influence development, physiology, inflammation, and carcinogenicity. Dysregulation of miRNA biogenesis, epigenetic, and genomic changes can drive proto-oncogenic or suppressive effects.\"}]","Potential Diagnostic Utility of microRNAs in Gastrointestinal Cancers - Review | PDF",1790234410,23]