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Potential Application of Self-Assembled Peptides and Proteins in Breast Cancer and Cervical Cancer. Int. J. Mol. Sci. 2023, 24, 17056. [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)ijms242317056  \nAcademic Editor: Bernard Haendler  \nReceived: 11 October 2023  \nRevised: 22 November 2023  \nAccepted: 30 November 2023  \nPublished: 2 December 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \nSchool of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, China;  \n[zhang_shidong@yeah.net](zhang_shidong@yeah.net) (S.Z.); [15567958349@163.com](15567958349@163.com) (M.C.); [jimmyg_98@163.com](jimmyg_98@163.com) (Z.G.);  \n[18744031073@163.com](18744031073@163.com) (T.L.); [lisyang1206@163.com](lisyang1206@163.com) (S.L.); [yuqx0221@163.com](yuqx0221@163.com) (Q.Y.)  \n* Correspondence: [caoll@ccucm.edu.cn](caoll@ccucm.edu.cn) (L.C.); [liuda@ccucm.edu.cn](liuda@ccucm.edu.cn) (D.L.)† These authors contributed equally to this work.  \nAbstract: Ongoing research is gradually broadening the idea of cancer treatment, with attention being focused on nanoparticles to improve the stability, therapeutic efficacy, targeting, and other important metrics of conventional drugs and traditional drug delivery methods. Studies have demonstrated that drug delivery carriers based on biomaterials (e.g., protein nanoparticles and lipids) and inorganic materials (e.g., metal nanoparticles) have potential anticancer effects. Among these carriers, self-assembled proteins and peptides, which are highly biocompatible and easy to standardize and produce, are strong candidates for the preparation of anticancer drugs. Breast cancer (BC) and cervical cancer (CC) are two of the most common and deadly cancers in women. These cancers not only threaten lives globally but also put a heavy burden on the healthcare system. Despite advances in medical care, the incidence of these two cancers, particularly CC, which is almost entirely preventable, continues to rise, and the mortality rate remains steady. Therefore, there is still a need for in-depth research on these two cancers to develop more targeted, efficacious, and safe therapies. This paper reviews the types of self-assembling proteins and peptides (e.g., ferritin, albumin, and virus-like particles) and natural products (e.g., soy and paclitaxel) commonly used in the treatment of BC and CC and describes the types of drugs that can be delivered using self-assembling proteins and peptides as carriers (e.g., siRNAs, DNA, plasmids, and mRNAs) . The mechanisms (including self-assembly) by which the natural products act on CC and BC are discussed. The mechanism of action of natural products on CC and BC and the mechanism of action of self-assembled proteins and peptides have many similarities (e.g., NF-KB and Wnt) . Thus, natural products using self-assembled proteins and peptides as carriers show potential for the treatment of BC and CC.  \nKeywords: self-assembled peptides and proteins; breast cancer; cervical cancer; targeted cancer therapy; drug delivery; natural products  \n1. Introduction  \nRecent medical developments include precision medicine and nanomedicine, which are also popular research subjects. Compared with traditional drugs and conventional drug delivery methods, nanoparticle-based drug delivery systems can improve drug stability and bioavailability a","cbCaipiQBrZVxNEN","https://ap.wps.com/l/cbCaipiQBrZVxNEN","pdf",2245762,25,"English","# Introduction\n## Nanomedicine and nanoparticle drug delivery\n## Self-assembled peptides and proteins as carriers\n## Breast cancer background\n## Cervical cancer background","[{\"question\":\"What cancer types are the review focused on and why?\",\"answer\":\"The review focuses on breast cancer and cervical cancer. Both threaten lives globally, and despite advances in care—especially for cervical cancer—incidence and mortality remain concerning, requiring more targeted and effective therapies.\"}]","Potential Application of Self-Assembled Peptides and Proteins in Breast Cancer and Cervical Cancer | PDF",1790225024,63]