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Single-crystal X-ray diffraction showed isostructurality with a previously reported Dy complex, forming dinuclear monomers bridged by an extended hydrogen-bond network, yielding [Ln2(5-npic)6(H2O)4]·(H2O)2 (Ln = Dy, Gd, Tb). Photoluminescence indicated ligand-centered emission. Antitumor testing in PC-3 cells showed 50–60% activity at 500 μg·mL−1, alongside high biocompatibility in HL-60 cells.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/potential-antiprostatic-performance-of-novel-lanthanide-complexes-based-on-5-nitropicolinic-acid/330669/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/potential-antiprostatic-performance-of-novel-lanthanide-complexes-based-on-5-nitropicolinic-acid/330669.png","ImageObject",300,407,{"name":92,"@type":93},"Ivy","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What lanthanide complexes were synthesized and how were they characterized?","Question",{"text":112,"@type":113},"Two new lanthanide complexes based on the 5-nitropicolinate ligand were obtained and fully characterized using single-crystal X-ray diffraction and photoluminescent studies.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What structural features were found by single-crystal X-ray diffraction?",{"text":117,"@type":113},"The compounds are isostructural to a previously reported Dy complex, forming dinuclear monomers linked through an extended hydrogen-bond network, giving the formula [Ln2(5-npic)6(H2O)4]·(H2O)2.",{"name":119,"@type":110,"acceptedAnswer":120},"How did the complexes perform biologically in prostate cancer and biocompatibility tests?",{"text":121,"@type":113},"In PC-3 prostate cancer cells, the materials showed significant anticancer activity (50–60% at 500 μg·mL−1). Both the complexes and their precursors demonstrated high biocompatibility in HL-60 human immunological cells.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},330669,1790322984,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":46,"preview_page_count":4},549758252649,"https://ap-avatar.wpscdn.com/avatar/8000253669c5317157?_k=1778319167496531819","JBIC Journal of Biological Inorganic Chemistry (2024) 29:331–338  \n[https://doi.org/10.1007/s00775-024-02054-0](https://doi.org/10.1007/s00775-024-02054-0)  \nPotential antiprostatic performance of novel lanthanide‑complexes based on 5‑nitropicolinic acid  \nAmalia García‑García1 · Pablo Cristobal‑Cueto2 · Tania Hidalgo2 · Iñigo J. Vitórica‑Yrezábal1 ·  \nAntonio Rodríguez‑Diéguez1 · Patricia Horcajada2 · Sara Rojas1  \nReceived: 17 November 2023 / Accepted: 20 February 2024 / Published online: 8 May 2024 © The Author(s) 2024  \nAbstract  \nTwo new lanthanide-complexes based on the 5-nitropicolinate ligand (5-npic) were obtained and fully characterized. Singlecrystal X-ray diffraction revealed that these compounds are isostructural to a Dy-complex, previously published by us, based on dinuclear monomers link together with an extended hydrogen bond network, providing a final chemical formula of [Ln2(5-npic)6(H2O)4]·(H2O)2, where Ln = Dy (1), Gd (2), and Tb (3) . Preliminary photoluminescent studies exhibited a ligand-centered emission for all complexes. The potential antitumoral activity of these materials was assayed in a prostatic cancer cell line (PC-3; the 2nd most common male cancerous disease), showing a significant anticancer activity (50–60% at 500 μg·mL−1) . In turn, a high biocompatibility by both, the complexes and their precursors in human immunological HL-60 cells, was evidenced. In view of the strongest toxic effect in the tumoral cell line provided by the free 5-npic ligand (~ 40–50%), the overall anticancer complex performance seems to be triggered by the presence of this molecule.  \nGraphical Abstract  \nKeywords 5-Nitropicolinic acid · Lanthanide · Coordination compounds · Single-crystal X-ray diffraction · Prostate cancer  \nAmalia García-García and Pablo Cristobal-Cueto contributed equally to this work.  \n* Patricia Horcajada [patricia.horcajada@imdea.org](patricia.horcajada@imdea.org)  \n* Sara Rojas [srojas@ugr.es](srojas@ugr.es)  \n1 Department of Inorganic Chemistry, Faculty of Science, University of Granada, Av. Fuente Nueva S/N,  \n18071 Granada, Spain  \n2 Advanced Porous Material Unit, IMDEA Energy Institute, Av. Ramón de La Sagra 3, 28935 Móstoles, Madrid, Spain  \nIntroduction  \nCancer is one of the leading causes of death worldwide, compromising more than 20 million people with nearly 10 million deaths worldwide only in 2020 [1, 2], remaining still as one of the biggest global health challenges in the twenty-first century. Particularly for men, prostate cancer is the second most frequent type of cancer, just after lung carcinoma, with ~ 1.3 million new diagnosis each year worldwide, making it a serious health concern [3]. Currently,  \nearly-stage prostate cancer treatments include prostate removal, hormone and/or radiotherapy [4 , 5], which are associated with numerous side effects such as urinary or erectile dysfunctions [6] . In advanced-stages, the frequent tumoral metastasis and/or the appearance of resistance to classical chemotherapeutic agents lead to inefficient therapies or prognosis. The current used chemotherapeutic agents (e.g. , mitoxantrone, estramustine, docetaxel) show short average lifetime with a great resistant generation rate [7] . In this sense, European Union (EU) has fostered a renewed commitment for cancer prevention, treatment and care for improvement the patient´s quality life through novel missions and actions based on repurposing medicines, underpinning data sharing or reinforce collaborations (e.g., Europe’s Beating Cancer Plan) . One of these approaches in recent years has been the use of metal complexes in chemotherapy [8, 9], as for instance platinum complexes like oxaliplatinor cisplatin [10–12], some of the most successful anticancer compounds clinically used for diverse cancers (ovarian, gastrointestinal, bladder, etc.). For that reason, the relevance of metallodrugs as therapeutic and imaging diagnostics has exponentially risen in recent years: since cisplatin (1978) to nume","cbCaimNoT4hrn6rF","https://ap.wps.com/l/cbCaimNoT4hrn6rF","pdf",1511073,"English","# Abstract\n# Graphical Abstract\n# Keywords\n# Introduction","[{\"question\":\"What lanthanide complexes were synthesized and how were they characterized?\",\"answer\":\"Two new lanthanide complexes based on the 5-nitropicolinate ligand were obtained and fully characterized using single-crystal X-ray diffraction and photoluminescent studies.\"},{\"question\":\"What structural features were found by single-crystal X-ray diffraction?\",\"answer\":\"The compounds are isostructural to a previously reported Dy complex, forming dinuclear monomers linked through an extended hydrogen-bond network, giving the formula [Ln2(5-npic)6(H2O)4]·(H2O)2.\"},{\"question\":\"How did the complexes perform biologically in prostate cancer and biocompatibility tests?\",\"answer\":\"In PC-3 prostate cancer cells, the materials showed significant anticancer activity (50–60% at 500 μg·mL−1). Both the complexes and their precursors demonstrated high biocompatibility in HL-60 human immunological cells.\"}]","Potential antiprostatic performance of novel lanthanide-complexes based on 5-nitropicolinic acid | PDF",1789989685]