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This study investigates how post-transcriptional regulation shapes AURKA expression across multiple cancers by performing a meta-analysis of TCGA -omics data from 18 cancer types. Results show increased AURKA mRNA in tumors versus normal tissues and reveal that AURKA expression depends heavily on post-transcriptional control in several cancers. Integrative analyses of AURKA mRNA/protein expression and the hsa-let-7a miRNA indicate a likely role for hsa-let-7a in modulating AURKA levels to different extents.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/post-transcriptional-control-drives-aurora-kinase-a-expression-in-human-cancers/332722/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/post-transcriptional-control-drives-aurora-kinase-a-expression-in-human-cancers/332722.png","ImageObject",300,407,{"name":92,"@type":93},"Eden","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-24","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":19},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the role of Aurora kinase A (AURKA) in cells and cancer?","Question",{"text":112,"@type":113},"AURKA is a major regulator of the cell cycle. High AURKA expression is associated with cancer, and disruptions in AURKA levels can affect its oncogenic activity.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does the study evaluate post-transcriptional regulation of AURKA across cancers?",{"text":117,"@type":113},"The study performs a meta-analysis of TCGA -omics data covering 18 cancer types and analyzes AURKA mRNA and protein expression alongside hsa-let-7a miRNA.",{"name":119,"@type":110,"acceptedAnswer":120},"What evidence links hsa-let-7a and alternative cleavage/polyadenylation to AURKA expression?",{"text":121,"@type":113},"Correlation and clustering analyses suggest hsa-let-7a is involved in controlling AURKA expression in several cancers. The study also measures differences in the short/long ratio of AURKA mRNA isoforms formed by alternative cleavage and polyadenylation (APA), proposing an interplay between APA and hsa-let-7a targeting.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},332722,1791050858,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":19,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":46,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":31,"preview_page_count":4},1374391974468,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","PLOS ONE  \nOPEN ACCESS  \nCitation: Cacioppo R, Rad D, Pagani G, Gandellini P, Lindon C (2024) Post-transcriptional control drives Aurora kinase A expression in human cancers. PLoS ONE 19(11): e0310625 . [https://doi](https://doi). org/10 .1371/journal.pone.0310625  \nEditor: Chandrabose Selvaraj, Saveetha University  \nPoonamallee Campus: SIMATS Deemed University, INDIA  \nReceived: June 26, 2024  \nAccepted: September 3, 2024  \nPublished: November 11, 2024  \nPeer Review History: PLOS recognizes the benefits of transparency in the peer review process; therefore, we enable the publication of all of the content of peer review and author responses alongside final, published articles. The editorial history of this article is available here:  \n[https://doi.org/10.1371/journal.pone.0310625](https://doi.org/10.1371/journal.pone.0310625)  \n[Copyright:](Copyright:) © [2024](2024) Cacioppo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.  \nData Availability Statement: The data underlying the results presented in the study are available in Supporting Information.  \nRESEARCH ARTICLE  \nPost-transcriptional control drives Aurora kinaseA expression in human cancers  \nRoberta Cacioppo1¤a *, Deniz Rad1¤b, Giulia Pagani2, Paolo Gandellini2, Catherine Lindon1 *  \n1 Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom, 2 Department of Biosciences, University of Milan, Milan, Italy  \n¤a Current address: MRC Laboratory of Molecular Biology, Cambridge, United Kingdom ¤b Current address: Trinity College, University of Cambridge, Cambridge, United Kingdom  \n* [rcacioppo@mrc-lmb.cam.ac.uk](rcacioppo@mrc-lmb.cam.ac.uk) (RC); [acl34@cam.ac.uk](acl34@cam.ac.uk) (CL)  \nAbstract  \nAurora kinase A (AURKA) is a major regulator of the cell cycle. A prominent association exists between high expression of AURKA and cancer, and impairment of AURKA levels can trigger its oncogenic activity. In order to explore the contribution of post-transcriptional regulation to AURKA expression in different cancers, we carried out a meta-analysis of  \n-omics data of 18 cancer types from The Cancer Genome Atlas (TCGA) . Our study confirmed a general trend for increased AURKA mRNA in cancer compared to normal tissues and revealed that AURKA expression is highly dependent on post-transcriptional control in several cancers. Correlation and clustering analyses of AURKA mRNA and protein expression, and expression of AURKA-targeting hsa-let-7a miRNA, unveiled that hsa-let-7a is likely involved to varying extents in controlling AURKA expression in cancers. We then measured differences in the short/long ratio (SLR) of the two alternative cleavage and polyadenylation (APA) isoforms of AURKA mRNA across cancers compared to the respective healthy counterparts. We suggest that the interplay between APA and hsa-let-7a targeting ofAURKA mRNA may influence AURKA expression in some cancers. hsa-let-7aand APA may also independently contribute to altered AURKA levels. Therefore, we argue that AURKA mRNA and protein expression are often discordant in cancer as a result of dynamic post-transcriptional regulation.  \nIntroduction  \nAURKA is a key regulator of the cell cycle, controlling centrosome maturation and mitotic spindle assembly [ 1] . AURKA is overexpressed and represents a marker of poor prognosis in abroad range of human malignancies [2–4] . Because of the significant association between high AURKA expression and cancer progression, poor prognosis, and drug resistance, AURKA is a preferred target for anti-cancer strategies, especially the use of small molecule kinase inhibitors [4, 5] and targeted proteolytic tools [6, 7] . However, even the most promising AURKA inhibitors are still under clinical studies and only alisertib has concluded phase III clinical assessment  \nPLOS ONE","cbCaieOcPdPEEjUD","https://ap.wps.com/l/cbCaieOcPdPEEjUD","pdf",2545627,"English","# Abstract\n# Introduction","[{\"question\":\"What is the role of Aurora kinase A (AURKA) in cells and cancer?\",\"answer\":\"AURKA is a major regulator of the cell cycle. High AURKA expression is associated with cancer, and disruptions in AURKA levels can affect its oncogenic activity.\"},{\"question\":\"How does the study evaluate post-transcriptional regulation of AURKA across cancers?\",\"answer\":\"The study performs a meta-analysis of TCGA -omics data covering 18 cancer types and analyzes AURKA mRNA and protein expression alongside hsa-let-7a miRNA.\"},{\"question\":\"What evidence links hsa-let-7a and alternative cleavage/polyadenylation to AURKA expression?\",\"answer\":\"Correlation and clustering analyses suggest hsa-let-7a is involved in controlling AURKA expression in several cancers. The study also measures differences in the short/long ratio of AURKA mRNA isoforms formed by alternative cleavage and polyadenylation (APA), proposing an interplay between APA and hsa-let-7a targeting.\"}]","Post-transcriptional control drives Aurora kinase A expression in human cancers | PDF",1789999201]