[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-420567-105":59,"doc-detail-420567-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","post-infectious-acquired-hemophilia-a-a-case-report-and-review-of-the-literature","Post-Infectious Acquired Hemophilia A - A Case Report and Review of the Literature","","A 52-year-old man without personal or family bleeding history developed extensive hematomas and skin bruising after prolonged antibiotic use. Laboratory workup showed coagulopathy with prolonged activated partial thromboplastin time and mild anemia; mixing studies and factor assays confirmed acquired hemophilia A with low factor VIII and high-titer factor VIII inhibitors. Corticosteroids and cyclophosphamide were initiated, producing gradual improvement in bleeding and coagulation parameters. Autoimmune diseases and malignancies were systematically excluded, supporting a link to the prolonged antibiotic exposure, and the patient remains in remission.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/post-infectious-acquired-hemophilia-a-a-case-report-and-review-of-the-literature/420567/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/post-infectious-acquired-hemophilia-a-a-case-report-and-review-of-the-literature/420567.png","ImageObject",300,407,{"name":92,"@type":93},"pixelkiddo","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-04","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What caused the patient’s acquired hemophilia A in this case?","Question",{"text":112,"@type":113},"The case links onset to immune dysregulation following a recent soft tissue infection and prolonged antibiotic therapy, after exclusion of autoimmune and neoplastic causes.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was acquired hemophilia A diagnosed?",{"text":117,"@type":113},"Diagnosis was confirmed by prolonged aPTT with an inhibitor pattern on mixing studies and factor assays showing markedly reduced factor VIII alongside high-titer factor VIII inhibitors.",{"name":119,"@type":110,"acceptedAnswer":120},"What treatments were used and what was the response?",{"text":121,"@type":113},"The patient received corticosteroids and cyclophosphamide, with gradual improvement in both bleeding symptoms and coagulation parameters. Follow-up showed reduced inhibitor levels and recovery of factor VIII activity, with ongoing clinical remission.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},420567,1790740165,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":24,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},962090883892,"https://ap-avatar.wpscdn.com/avatar/e00115db34f3e0f11b?x-image-process=image/resize,m_fixed,w_180,h_180&k=1790152879550218658","Case Reports  \nPost-Infectious Acquired Hemophilia A: A Case Report and Review ofthe Literature  \nJandir Mendonça Nicacio, MD, MSc, PhD1,2, Christian Mangueira Monteiro de Araújo Júnior, MD1,2, Naiara de Souza Barros, MD1,2, Paulo Inocêncio da Fonseca Cufua, MD1,2, André Luis Magalhães Fernandes, MD3  \n1 Department of Medicine, Federal University ofSão Francisco Valley,  \n2 University Hospital, Federal University of Vale do São Francisco (HU-UNIVASF/EBSERH), Petrolina, Pernambuco, Brazil,  \n3 Division of Hematology, Hospital Regional Juazeiro, Juazeiro (BA), Brazil  \nJournal of Brown Hospital Medicine Vol. 5, Issue 1, 2025  \nArticle Information  \nKeywords: Acquired hemophilia A, Factor VIII inhibitors, Coagulopathy  \n[https://doi.org/10.56305/001c.147407](https://doi.org/10.56305/001c.147407)  \nSubmitted: September 22, 2025 EST  \nAccepted: November 15, 2025 EST  \nPublished: January 01, 2026 EST  \nAbstract  \nA 52-year-old man with no personal or family history of bleeding presented with extensive hematomas and skin bruising following prolonged antibiotic use. Initial laboratory evaluation revealed coagulopathy, with an elevated activated partial thromboplastin time and mild anemia. Mixing studies and factor assays confirmed the diagnosis of acquired hemophilia A, characterized by low factor VIII levels and high-titer factor VIII inhibitors. The patient was initiated on corticosteroids and cyclophosphamide, leading to gradual improvement in both bleeding symptoms and coagulation parameters. Comprehensive evaluations excluded autoimmune diseases and malignancies, supporting the conclusion that the condition was linked to prolonged antibiotic use. The patient continues to be in clinical remission after targeted therapy.  \nbackground  \nAcquired hemophilia A (AHA) is a rare and potentially life-threatening disorder characterized by the sudden development of autoantibodies that inhibit coagulation factor VIII (FVIII) function or accelerate its clearance.1 The estimated incidence is approximately 1 to 1.5 cases per million individuals per year.2 Despite its rarity, AHA poses a significant clinical challenge due to its potential for severe bleeding complications, particularly when the diagnosis and treatment are delayed. The mortality rate can reach up to 41% in untreated cases.2,3 We describe a rare case of acquired hemophilia A associated with an unusual clinical condition, highlighting key diagnostic and therapeutic considerations.  \ncase presentation  \nA 52-year-old male merchant with a medical history of hyperuricemia, systemic arterial hypertension, and diabetes mellitus presented in September 2023 with swelling, pain, and fever in his right hand, consistent with a soft tissue infection as noted in Figure 1.  \nThe patient reported no illnesses in the preceding three months, including arboviral infections, influenza, or COVID-19. He underwent prolonged antibiotic therapy with benzathine penicillin (1,200,000 IU intramuscularly), cephalexin (500 mg orally), and ciprofloxacin (500 mg twice daily) for over 30 days, resulting in a slow  \nFigure 1. Infected lesion of the right hand  \nbut complete resolution of the lesions. Approximately two months after recovery, without other infections, he began experiencing extensive bruising and hematomas on his upper limbs and thighs following minimal trauma (Figure 2) . He denied mucosal bleeding, such as epistaxis, gingival bleeding, hematuria, or hematochezia. During the infection, he experienced significant weight loss of approximately 20 kg, which stabilized and returned to baseline within 45 days of clinical improvement.  \nThe patient was referred to the hematology service for evaluation of the bleeding symptoms. Initial laboratory tests revealed hemoglobin of 11.9 g/dL, leukocyte count of 7,500 cells/mm³ (78% segmented neutrophils, 20% lymphocytes), platelet count of 342,000 cells/mm³,  \nFigure 2. Bruising and extensive cutaneous bleeding in the right upper limb, left thigh, lumbar region, ","cbCaidiST3XyA12K","https://ap.wps.com/l/cbCaidiST3XyA12K","pdf",413869,"English","# Abstract\n# Background\n# Case Presentation\n## Clinical history and triggering infection\n## Diagnostic evaluation and coagulation findings\n## Treatment and follow-up outcome","[{\"question\":\"What caused the patient’s acquired hemophilia A in this case?\",\"answer\":\"The case links onset to immune dysregulation following a recent soft tissue infection and prolonged antibiotic therapy, after exclusion of autoimmune and neoplastic causes.\"},{\"question\":\"How was acquired hemophilia A diagnosed?\",\"answer\":\"Diagnosis was confirmed by prolonged aPTT with an inhibitor pattern on mixing studies and factor assays showing markedly reduced factor VIII alongside high-titer factor VIII inhibitors.\"},{\"question\":\"What treatments were used and what was the response?\",\"answer\":\"The patient received corticosteroids and cyclophosphamide, with gradual improvement in both bleeding symptoms and coagulation parameters. Follow-up showed reduced inhibitor levels and recovery of factor VIII activity, with ongoing clinical remission.\"}]","Post-Infectious Acquired Hemophilia A - A Case Report and Review of the Literature | PDF",1790621490,13]