[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-435539-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-435539-en":131},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","post-anaphylactic-shock-myocardial-infarction-kounis-syndrome-a-rare-case-report","Post anaphylactic shock myocardial infarction(Kounis syndrome): a rare case report","","A rare clinical report describes Kounis syndrome presenting as post anaphylactic shock myocardial infarction after moxifloxacin ingestion in a 55-year-old male with vasculitis and smoking history. Shortly after drug exposure, he developed epigastric pain, dizziness, sweating, and acute chest pain. ECG showed ST-segment elevation, labs demonstrated eosinophil and basophil elevation, and coronary angiography revealed significant LAD stenosis treated with stent and balloon. Management combined corticosteroids, antihistamines, and dual antiplatelet therapy, with normalization of counts and stable discharge.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/post-anaphylactic-shock-myocardial-infarction-kounis-syndrome-a-rare-case-report/435539/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/post-anaphylactic-shock-myocardial-infarction-kounis-syndrome-a-rare-case-report/435539.png","ImageObject",300,407,{"name":42,"@type":43},"WPS_1790064749","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-29",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",13,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is Kounis syndrome in this case report?","Question",{"text":63,"@type":64},"Kounis syndrome is myocardial infarction occurring in the setting of an anaphylactic shock, driven by release of allergic mediators that affect coronary arteries and can lead to spasm and ischemia.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What trigger led to the patient’s allergic reaction?",{"text":68,"@type":64},"The patient developed symptoms after ingesting moxifloxacin, which is described as a known trigger for Kounis syndrome.",{"name":70,"@type":61,"acceptedAnswer":71},"How was the condition diagnosed and treated?",{"text":72,"@type":64},"Diagnosis used ECG showing ST-segment elevation and labs with elevated eosinophil and basophil counts; cardiac catheterization identified significant LAD stenosis. Treatment included a stent and balloon, plus corticosteroids, antihistamines, and dual antiplatelet therapy.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},435539,1790736488,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":33,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":124,"preview_page_count":4},3985747859154,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Case Report  \n# Post anaphylactic shock myocardial infarction(Kounis syndrome): a rare case report\n\nAmir Abadi, MDa,*, Usra Ghanem, MDb , Shaker Nierat, MDc , Marwan Joma, MDa  \nIntroduction and Importance: Kounis syndrome is a rare condition described by acute coronary syndrome following an allergicreaction. This case report highlights a unique presentation of Kounis syndrome following moxifloxacin ingestion in a patient withvasculitis and a history of smoking.  \nCase Presentation: A 55-year-old male smoker with a history of vasculitis presented with acute chest pain 1 hour aftermoxifloxacin ingestion. The patient developed epigastric pain, dizziness, and sweating. ECG showed ST-segment elevation inleads II, III, and aVF. Initial lab work revealed elevated eosinophil and basophil counts consistent with an allergic reaction. Cardiaccatheterization identified significant stenosis in the left anterior descending artery, which was managed with a stent and a balloon.The patient was treated with corticosteroids, antihistamines, and dual antiplatelet therapy. Eosinophil and basophil counts becamenormal, andthe patient was discharged in a stable condition.  \nClinical Discussion: This case showcases the intersection between allergic reactions and coronary events. Moxifloxacin isa known trigger for Kounis syndrome. The patient’svasculitis and smoking history likely predisposed him to coronary inflammation,making him susceptible to Kounis syndrome. While Kounis syndrome remains underdiagnosed duetothe overlapping symptoms,timely recognition and management addressing both the allergic and cardiac components are crucial.  \nConclusion: This article highlights the importance of considering Kounis syndrome inpatients presenting with ACS following anallergic reaction, particularly in those with predisposing factors. Prompt diagnosis and intervention are essential to improveoutcomes.  \nKeywords: anaphylactic shock, Kounis, moxifloxacin, myocardial infarction  \n## Introduction\n\nAnaphylactic shock is a life-threatening allergic reaction identi -fied by its sudden onset and systematic effects, including vaso -dilation, smooth muscle contraction, and increased vascularpermeability. These effects are caused by releasing chemicalmediators (cytokines and histamine), resulting in hypotensiveshock. This can lead to respiratory failure and multiple organfailures. Various triggers can cause this shock, such as foods,medications, and insect stings[1,2] .  \nPathologically, myocardial infarction is defined as myocardialcell death due to prolonged ischemia[3] . Atherosclerosis plaquesrepresent the leading cause for it because of its relation to thrombus  \naEmergency Department, Ibn Sina Specialized Hospital, Jenin, Palestine, bFacultyof Medicine, Al-Quds University, Abu-dis, Palestine and cCardiology Department,Ibn Sina Specialized Hospital, Jenin, Palestine  \nSponsorships or competing interests that maybe relevant to content are disclosedatthe end of this article.  \n*Corresponding author. Address: Emergency Department, Ibn Sina SpecializedHospital, Al-Kharubeh neighborhood, Jenin P209, Palestine.  \nE-mail: ameerabbadi8@gmail.com (A. Abadi).  \nCopyright © 2025 The Author(s). Published by Wolters Kluwer Health, Inc. This is anopen access article distributed under the terms of the Creative CommonsAttribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where itispermissible to download and share the work provided itis properly cited. The workcannot be changed in any way or used commercially without permission from thejournal.  \nAnnals of Medicine & Surgery (2026) 88:915–918Received 6 March 2025; Accepted 27 November 2025Published online 11 December 2025http://dx.doi.org/10.1097/MS9.0000000000004544  \nformation. Itis clinically typically presented with chest pain, short -ness of breath, and excessive sweating, and is managed primarilyby enhancing the blood flow either medically or surgically[4] .  \nHowever, if a myocardial infarction happens in the s","cbCaiciEAxmuuuw1","https://ap.wps.com/l/cbCaiciEAxmuuuw1","pdf",548588,"English","# Introduction\n## Case presentation\n## Clinical discussion\n## Conclusion","[{\"question\":\"What is Kounis syndrome in this case report?\",\"answer\":\"Kounis syndrome is myocardial infarction occurring in the setting of an anaphylactic shock, driven by release of allergic mediators that affect coronary arteries and can lead to spasm and ischemia.\"},{\"question\":\"What trigger led to the patient’s allergic reaction?\",\"answer\":\"The patient developed symptoms after ingesting moxifloxacin, which is described as a known trigger for Kounis syndrome.\"},{\"question\":\"How was the condition diagnosed and treated?\",\"answer\":\"Diagnosis used ECG showing ST-segment elevation and labs with elevated eosinophil and basophil counts; cardiac catheterization identified significant LAD stenosis. Treatment included a stent and balloon, plus corticosteroids, antihistamines, and dual antiplatelet therapy.\"}]","Post anaphylactic shock myocardial infarction(Kounis syndrome): a rare case report | PDF",1790674022]