[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-328309-105":59,"doc-detail-328309-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","possible-association-between-polyomaviruses-and-gastrointestinal-complications-a-narrative-review","Possible association between polyomaviruses and gastrointestinal complications - a narrative review","","Polyomaviruses are small double-stranded DNA viruses linked to development of human diseases, with emerging evidence suggesting an association with gastrointestinal (GI) cancers. The review discusses JC polyomavirus (JCPyV), BK polyomavirus (BKPyV), and Merkel cell polyomavirus (MCPyV), highlighting molecular and epidemiological studies, including reports of viral genomes in cancerous tissues. Despite proposed links, direct causal effects on human-cell transformation and GI cancer progression remain under investigation, and additional studies are required to clarify cause-and-effect relationships. Findings could influence diagnosis, treatment, and prevention, and guide targeted therapies and biomarker discovery.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/possible-association-between-polyomaviruses-and-gastrointestinal-complications-a-narrative-review/328309/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/possible-association-between-polyomaviruses-and-gastrointestinal-complications-a-narrative-review/328309.png","ImageObject",300,407,{"name":92,"@type":93},"Aria","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Which polyomaviruses are examined in this narrative review?","Question",{"text":112,"@type":113},"The review focuses on JC polyomavirus (JCPyV), BK polyomavirus (BKPyV), and Merkel cell polyomavirus (MCPyV), including evidence related to GI cancers and complications.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What evidence suggests a link between polyomaviruses and gastrointestinal cancers?",{"text":117,"@type":113},"Molecular and epidemiological studies have proposed associations, including reports of viral genomes found in cancerous tissues, particularly for colorectal cancer involving JCPyV and BKPyV.",{"name":119,"@type":110,"acceptedAnswer":120},"Is a direct cause-and-effect relationship established between polyomaviruses and GI cancer progression?",{"text":121,"@type":113},"No. The review states that although associations are proposed, the major role and causal link remain under extensive investigation, and further surveys are needed to establish definitive cause-and-effect.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},328309,1790561244,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},2336464648322,"https://ap-avatar.wpscdn.com/avatar/2200025388227c56fec?_k=1778556882303663488","Gastroenterology and Hepatology From Bed to Bench.  \n2024 RIGLD, Research Institute for Gastroenterology and Liver Diseases   \nREVIEW ARTICLE  \np-ISSN: 2008-2258 e-ISSN: 2008-4234  \nPossible association between polyomaviruses and gastrointestinal complications: a narrative review  \nPiruz Shadbash1,2, Seyed Masoud Hosseini2, Shahrzad Shoraka2,3, Amir Ghaemi4, Mehrdad Haghazali5, Seyed Reza Mohebbi3  \n1Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran  \n2Department of Microbiology and Microbial Biotechnology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran  \n3Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran  \n4Department of Virology, Pasteur Institute of Iran, Tehran, Iran  \n5Behbood Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran  \nABSTRACT  \nPolyomaviruses are a group of small, double-stranded DNA viruses that are known to be associated with the development of certain human diseases, but there is evidence that these viruses might be associated with gastrointestinal (GI) cancers. Several polyomaviruses have been identified, such as JC polyomavirus (JCPyV), BK polyomavirus (BKPyV) and recently Merkel cell polyomavirus (MCPyV) . Although the direct effects of polyomaviruses on transformation of human cells and cancer development are not clearly recognized, their association with certain human diseases including GI cancers has been proposed through several molecular and epidemiological studies. For example, JCPyV and BKPyV have been linked to colorectal cancer, as there is growing evidence of finding viral genomes in cancerous tissues. Nevertheless, the major role of JCPyV, BKPyV and MCPyV in colorectal cancer progression is still under extensive investigation, and further surveys is required to establish a conclusive cause-and-effect relationship. Understanding the role of these viruses in cancer development has significant implications for diagnosis, treatment, and prevention strategies. It seems that proving a causal link between polyomaviruses and GI cancers might provide a novel path for targeted therapies or design and development of specific therapeutic vaccines. In addition, performing research on the possible link can provide insights into the underlying molecular mechanisms of carcinogenesis, potentially leading to the identification of novel biomarkers. This review focuses on polyomaviruses, in particular a recently discovered polyomavirus, MCPyV, and their possible link with human gastrointestinal disorders.  \nKeywords: Merkel cell polyomavirus, JC polyomavirus, BK polyomavirus, gastrointestinal cancer, Intestinal metastasis, programmed cell death protein 1, programmed cell death 1 ligand 1.  \n(Please cite as: Shadbash P, Hosseini SM, Shoraka S, Ghaemi A, Haghazali M, Mohebbi SR. Possible association between polyomaviruses and gastrointestinal complications: a narrative review. Gastroenterol Hepatol Bed Bench 2024;17(2):121-131. [https://doi.org/10.22037/ghfbb.v17i2.2796](https://doi.org/10.22037/ghfbb.v17i2.2796)).  \nIntroduction  \nIt is estimated that more than ten percent of all human cancers worldwide are associated with  \nReceived: 21 November 2023 Accepted: 03 February 2024 Reprint or Correspondence: Seyed Reza Mohebbi, Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.  \ninfectious agents, with viruses accounting for significant part of these cases (1, 2) . Human tumor viruses include hepatitis B virus (HBV); hepatitis C virus (HCV); human T-cell lymphotropic virus (HTLV); Epstein-Barr virus (EBV); human herpesvirus  \n","cbCaibWoprAlM2wN","https://ap.wps.com/l/cbCaibWoprAlM2wN","pdf",464640,11,"English","# Introduction\n## Polyomaviruses and GI cancer risk\n## MCPyV discovery, transmission, and clinical context","[{\"question\":\"Which polyomaviruses are examined in this narrative review?\",\"answer\":\"The review focuses on JC polyomavirus (JCPyV), BK polyomavirus (BKPyV), and Merkel cell polyomavirus (MCPyV), including evidence related to GI cancers and complications.\"},{\"question\":\"What evidence suggests a link between polyomaviruses and gastrointestinal cancers?\",\"answer\":\"Molecular and epidemiological studies have proposed associations, including reports of viral genomes found in cancerous tissues, particularly for colorectal cancer involving JCPyV and BKPyV.\"},{\"question\":\"Is a direct cause-and-effect relationship established between polyomaviruses and GI cancer progression?\",\"answer\":\"No. The review states that although associations are proposed, the major role and causal link remain under extensive investigation, and further surveys are needed to establish definitive cause-and-effect.\"}]","Possible association between polyomaviruses and gastrointestinal complications - a narrative review | PDF",1789979278,28]