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The article reports a 31-year-old man with poorly differentiated infiltrating squamous cell carcinoma classified as CUP after extensive workup. The tumor had an exceptional perineal presentation, with diagnostic and therapeutic steps involving advanced imaging and a multidisciplinary approach. The surgically removed lesion confirmed squamous histopathology, and one year after surgery the patient remained in complete remission.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/poorly-differentiated-squamous-cell-carcinoma-of-unknown-primary-location-a-case-report-of-perineal-presentation/336714/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/poorly-differentiated-squamous-cell-carcinoma-of-unknown-primary-location-a-case-report-of-perineal-presentation/336714.png","ImageObject",300,407,{"name":92,"@type":93},"Levi","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What clinical challenge does CUP represent in oncology?","Question",{"text":112,"@type":113},"CUP refers to cancers where the primary origin cannot be identified. The article notes it is a significant clinical challenge, representing about 1% to 5% of all cancer diagnoses.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How did the patient present and how was the lesion evaluated?",{"text":117,"@type":113},"The patient, a 31-year-old man, developed gradually worsening perineal pain over six months. A nodular lesion in the urogenital triangle was surgically removed, and histopathology confirmed poorly differentiated squamous cell carcinoma.",{"name":119,"@type":110,"acceptedAnswer":120},"Why was the condition classified as unknown primary, and what was the outcome?",{"text":121,"@type":113},"Despite extensive examinations by a multidisciplinary team, the source of the tumor could not be determined, leading to classification as CUP. One year after surgery, the patient remained in complete remission.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},336714,1790628145,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":29,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},7971461740909,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","International Journal of Surgery Case Reports 122 (2024) 110169  \nContents lists available at ScienceDirect  \nInternational Journal of Surgery Case Reports  \njournal [homepage:](homepage: www.elsevier.com/locate/ijscr)[ www.elsevier.com/locate/ijscr](homepage: www.elsevier.com/locate/ijscr)  \n| Case report\u003Cbr>Poorly differentiated squamous cell carcinoma of unknown primary location a case report of perineal presentation\u003Cbr>Younes Hourya, 1 , Anas Taghouana, *, 1 , Hamza Raisa , Ghassane El Omria , Moussaab Rachida , Mohamed Reda Cherkaoui Jaouadb , Abdeljalil Heddata\u003Cbr>a Department of Urology, Cheikh Khalifa International University Hospital, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, Morocco b Department of Radiology, Cheikh Khalifa International University Hospital, Mohammed VI, University of Sciences and Health (UM6SS), Casablanca, Morocco |  |\n| --- | --- |\n| A R T I C L E I N F O\u003Cbr>Keywords: Male\u003Cbr>Neoplasms, unknown primary/diagnosis*\u003Cbr>Neoplasms, unknown primary/epidemiology*\u003Cbr>Neoplasms, unknown primary/therapy* Carcinoma, squamous cell*/surgery\u003Cbr>Carcinoma, squamous cell*/pathology Pelvic neoplasms* | A B S T R A C T\u003Cbr>Introduction: Cancers of unknown primary origin (CUP) pose a significant clinical challenge, representing a small percentage (1 to 5 %) of overall cancer cases. The patient is a 31-year-old male who has been diagnosed with poorly differentiated infiltrating squamous cell carcinoma, which has been classified as CUP. The exceptional perineal presentation and diagnostic process serve as a reminder of the diverse nature of CUPs and the crucial role played by advanced imaging methods and a multidisciplinary approach. The inclusion of this case, the seventh one in the literature, deepens our understanding of CUPs.\u003Cbr>Presentation of case: A 31-year-old man came in with a gradual onset of perineal pain that had been worsening for the past six months. A nodular lesion in the urogenital triangle, infiltrating the bulbo spongiosus muscle, was surgically removed. The histopathology results confirmed a poorly differentiated squamous cell carcinoma. Despite conducting extensive examinations, the multidisciplinary team was unable to determine the source of the tumour, classifying it as CUP. One year post-surgery, the patient remains in complete remission.\u003Cbr>Discussion: The management of CUPs can be challenging because of the variety of their origins and presentations. The importance of advanced imaging, pathological and biological techniques, as well as meticulous surgical intervention, is emphasized in this case, as it helps in avoiding unnecessary adjuvant therapies.\u003Cbr>Conclusion: This case highlights the significance of a customized and interdisciplinary approach in effectively managing CUPs, especially when they present in unusual ways. Timely surgical intervention, backed by comprehensive imaging and pathological analysis, can result in positive results. |\n\n1. Introduction  \nCancers of unknown primary origin (CUP) represent a significant clinical challenge, accounting for approximately 1 % to 5 % of all cancer diagnoses [1]. The exceptional aspect of this case is the uncommon location and the patient’s clinical characteristics [1,2], which contribute to our comprehension of CUP and its management. This contribution emphasizes the importance of tailoring diagnostic and therapeutic approaches to the intricate and varied nature of these uncommon cases. This case study presents a rare instance of poorly differentiated infiltrating squamous cell carcinoma in the perineum of a male patient, with  \nthe primary location being unknown. This is the seventh reported case in the literature and involves a 31-year-old patient with no significant medical history or apparent risk factors [3].  \n2. Presentation of case  \nWe present, in accordance with the SCARE guidelines [4], a case of perineal poorly differentiated squamous cell carcinoma of unknown primary location.  \nA man, aged 31, came to t","cbCaio94bm2BBc1l","https://ap.wps.com/l/cbCaio94bm2BBc1l","pdf",2797948,"English","# Introduction\n# Presentation of case\n# Discussion\n# Conclusion","[{\"question\":\"What clinical challenge does CUP represent in oncology?\",\"answer\":\"CUP refers to cancers where the primary origin cannot be identified. The article notes it is a significant clinical challenge, representing about 1% to 5% of all cancer diagnoses.\"},{\"question\":\"How did the patient present and how was the lesion evaluated?\",\"answer\":\"The patient, a 31-year-old man, developed gradually worsening perineal pain over six months. A nodular lesion in the urogenital triangle was surgically removed, and histopathology confirmed poorly differentiated squamous cell carcinoma.\"},{\"question\":\"Why was the condition classified as unknown primary, and what was the outcome?\",\"answer\":\"Despite extensive examinations by a multidisciplinary team, the source of the tumor could not be determined, leading to classification as CUP. One year after surgery, the patient remained in complete remission.\"}]","Poorly differentiated squamous cell carcinoma of unknown primary location - a case report of perineal presentation | PDF",1790016338,15]