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The methods section describes inclusion of 150 lung cancer cases and 150 matched controls from the Lianyungang cohort, using univariate and multivariate logistic regression to assess associations with incidence risk. Results report that poor sleep quality correlates with higher incidence risk (P=0.033, OR=1.83, 95% CI 1.05–3.19), with elevated risk also observed in smokers.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/poor-sleep-quality-association-with-higher-lung-cancer-risk-a-nested-case-control-study/380734/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/poor-sleep-quality-association-with-higher-lung-cancer-risk-a-nested-case-control-study/380734.png","ImageObject",300,407,{"name":92,"@type":93},"Guten tag","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-24","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What relationship does the study evaluate between sleep and lung cancer?","Question",{"text":112,"@type":113},"The study examines whether poor sleep quality is associated with higher lung cancer incidence risk.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was the nested case-control study designed?",{"text":117,"@type":113},"It included 150 lung cancer cases and 150 matched controls drawn from the Lianyungang cohort, and analyzed risk factors using univariate and multivariate logistic regression.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the key findings for poor sleep quality and risk?",{"text":121,"@type":113},"Poor sleep quality was linked to increased lung cancer incidence risk (P=0.033; OR=1.83; 95% CI 1.05–3.19). Among individuals with poor sleep quality, smoking further increased incidence risk.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},380734,1790792557,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},687212321768,"https://ap-avatar.wpscdn.com/avatar/a0010bdbe886d2fe77?x-image-process=image/resize,m_fixed,w_180,h_180&k=1789897067658708522","Submitted 13 April 2023  \nAccepted 8 November 2023 Published 15 December 2023  \nCorresponding authors  \nHan-Ping Shi, [shihp@ccmu.edu.cn](shihp@ccmu.edu.cn)[ ](shihp@ccmu.edu.cn)Xiao-Bin Wang, [xwang82@jhu.edu](xwang82@jhu.edu)  \nAcademic editor Truc Thanh Thai  \nAdditional Information and Declarations can be found on page 10  \nDOI 10.7717/peerj.16540  \n Copyright 2023 Ruan et al.  \nDistributed under  \nCreative Commons CC-BY 4.0  \nPoor sleep quality association with higher lung cancer risk: a nested case-control study  \nGuo-Tian Ruan 1,2,3, *, Ya-Ping Wei4, *, Yi-Zhong Ge1,2,3, Li-Shun Liu5,6, Zi-Yi Zhou5,6, Sultan Mehmood Siddiqi5, Qiang-Qiang He5,  \nShu-Qun Li6, Jia-Feng Xu6, Yun Song7,8, Qi Zhang 1,2,3, Xi Zhang1,2,3, Ming Yang 1,2,3, Ping Chen9,10, Yong Sun 11, Xiao-Bin Wang12,  \nBin-Yan Wang6,8 and Han-Ping Shi 1,2,3  \n1 National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing, China  \n2 Key Laboratory of Cancer FSMP for State Market Regulation, Beijing, China  \n3 Department of Gastrointestinal Surgery/Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, China  \n4 College of Public Health, Shanghai University of Medicine and Health Sciences, Shanghai, China  \n5 Graduate School at Shenzhen, Tsinghua University, Shenzhen, China  \n6 Shenzhen Evergreen Medical Institute, Shenzhen, China  \n7 AUSA Research Institute, Shenzhen AUSA Pharmed Co Ltd, Shenzhen, China  \n8 Institute for Biomedicine, Anhui Medical University, Hefei, China  \n9 Inspection and Testing Center, Key Laboratory of Cancer FSMP for State Market Regulation, Shenzhen, China  \n10 College of Pharmacy, Jinan University, Guangzhou, China  \n11 The First People’s Hospital of Lianyungang City, the First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang, China  \n12 Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, USA  \n* These authors contributed equally to this work.  \nABSTRACT  \nBackground: Little is known about the relationship between sleep quality and lung cancer incidence. Thus, this study was conducted to investigate the potential connection between sleep quality and lung cancer incidence.  \nMethods: We performed and selected a nested case–control study that included 150 lung cancer cases and 150 matched controls based on the Lianyungang cohort. Univariate and multivariate logistic regression was utilized to investigate the connection between potential risk factors and lung cancer incidence risk.  \nResults: In this study, the average age of participants was 66.5 ± 9.1 years, with 58.7% being male, and 52.7% reportedly experiencing sleep quality problems. The results of multivariate logistic regression showed that poor sleep quality was connected to an increased lung cancer incidence risk (P = 0.033, odds ratio = 1.83, 95% confidence interval = [1.05–3.19]) compared with those with good sleep quality. The stratified analyses showed a significantly positive connection between poor sleep quality (vs. good sleep quality) and cancer risk in smokers (vs. non-smoker, P for interaction = 0.085) . The combined effect analysis indicated that smokers with poor sleep quality suffered from a 2.79-fold increase in cancer incidence rates when compared with non-smokers with good sleep quality.  \nHow to cite this article Ruan G-T, Wei Y-P, Ge Y-Z, Liu L-S, Zhou Z-Y, Siddiqi SM, He Q-Q, Li S-Q, Xu J-F, Song Y, Zhang Q, Zhang X, Yang M, Chen P, Sun Y, Wang X-B, Wang B-Y, Shi H-P. 2023. Poor sleep quality association with higher lung cancer risk: a nested  \ncase-control study. PeerJ 11:e16540 DOI 10.7717/peerj.16540  \nConclusions: Poor sleep quality was positively connected to an increased lung cancer incidence risk. In addition, among those individuals with poor sleep quality, smoking increased the lung cancer incidence risk.  \nSubjects Epidemiology, Oncology, Public Health, Respi","cbCaipbtGknLLmIe","https://ap.wps.com/l/cbCaipbtGknLLmIe","pdf",1005038,15,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusions\n# Introduction","[{\"question\":\"What relationship does the study evaluate between sleep and lung cancer?\",\"answer\":\"The study examines whether poor sleep quality is associated with higher lung cancer incidence risk.\"},{\"question\":\"How was the nested case-control study designed?\",\"answer\":\"It included 150 lung cancer cases and 150 matched controls drawn from the Lianyungang cohort, and analyzed risk factors using univariate and multivariate logistic regression.\"},{\"question\":\"What were the key findings for poor sleep quality and risk?\",\"answer\":\"Poor sleep quality was linked to increased lung cancer incidence risk (P=0.033; OR=1.83; 95% CI 1.05–3.19). Among individuals with poor sleep quality, smoking further increased incidence risk.\"}]","Poor sleep quality association with higher lung cancer risk - a nested case-control study | PDF",1790241466,38]