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Metabolic control used glycated hemoglobin, blood pressure, and cholesterol; depressive symptoms used CES-D7. Logistic regression stratified by metabolic control assessed associations while adjusting for relevant covariates.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/poor-glycemic-control-and-microvascular-complications-key-drivers-of-depressive-symptoms-in-adults-with-diabetes/452477/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/poor-glycemic-control-and-microvascular-complications-key-drivers-of-depressive-symptoms-in-adults-with-diabetes/452477.png","ImageObject",300,407,{"name":42,"@type":43},"kopisore","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-04","2026-09-30",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",10,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"How were depressive symptoms measured in the study?","Question",{"text":63,"@type":64},"Depressive symptoms were assessed using the CES-D7 scale.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What indicators defined metabolic control?",{"text":68,"@type":64},"Metabolic control was defined using glycated hemoglobin, blood pressure, and cholesterol levels.",{"name":70,"@type":61,"acceptedAnswer":71},"What is the main finding regarding poor glycemic/metabolic control and depressive symptoms?",{"text":72,"@type":64},"Poor metabolic control was associated with a higher prevalence of depressive symptoms, especially among participants with microvascular complications.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},452477,1791034535,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":55,"slug":125},"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":55,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":144,"preview_page_count":4},962090880963,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","Escamilla-Nuñez etal. Diabetology & Metabolic Syndrome (2026) 18:8 [https://doi.org/10.1186/s13098-025-02043-6](https://doi.org/10.1186/s13098-025-02043-6)  \nDiabetology & Metabolic Syndrome  \nREVIEW Open Access  \nPoor glycemic control and microvascular complications: key drivers of depressive symptoms in adults with diabetes  \nConsuelo Escamilla-Nuñez 1, Rosalba Rojas-Martínez 1, Carlos A. Aguilar-Salinas2,3, Martin Romero-Martínez4, Paloma Almeda-Valdés2,5 and Lilia Castro-Porras6*  \nAbstract  \nAims To analyze the association between depressive symptoms and diabetes complications, stratified by metabolic control, in Mexican adults with type 2 diabetes mellitus.  \nMaterials and methods We analyzed data from adults aged 20 years and older with self-reported diabetes from the 2018–2019 Mexican National Health and Nutrition Survey (ENSANUT) . Diabetes complications were categorized as microvascular, macrovascular, or other. Metabolic control was defined based on glycated hemoglobin, blood pressure, and cholesterol levels. Depressive symptoms were assessed using the CES-D7 scale. Logistic regression models were stratified by metabolic control to determine the association between complications and depressive symptoms, adjusting for relevant covariates.  \nResults Among adults with poor metabolic control, depressive symptoms were significantly more prevalent in those with complications (47 . 2%, 95% CI: 46 .4–53. 9) than in those without (27 . 9%, 95% CI: 24 .4–31. 7) . Among individuals with good metabolic control, the prevalence of depressive symptoms was higher in those with complications (48 . 8%, 95% CI: 34 .6–63. 2) than in those without (31 . 3%, 95% CI: 23 .6–40. 2), although the difference was not statistically significant. In those with poor metabolic control, both microvascular and other complications were significantly associated with depressive symptoms (adjusted odds ratios [ adjOR] 2.3 [1.6–3.5] and 2.3 [1.4–3.7], respectively) . Conclusions Poor metabolic control is associated with a higher prevalence of depressive symptoms, especially inpatients with microvascular complications. These findings highlight the importance of integrating mental health screening and intervention into diabetes care to support emotional well-being and prevent adverse outcomes. Keywords Type 2 diabetes, Depressive symptoms, Glycemic control, Mental health, Diabetes complications  \n*Correspondence:  \nLilia Castro-Porras  \n[liliacastrop@comunidad. unam. mx](liliacastrop@comunidad. unam. mx)  \n1Center for Population Health Research, National Institute of Public Health, Cuernavaca, Morelos, Mexico  \n2Research Division, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico  \n3Metabolic Diseases Research Unit, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico  \n4Center for Evaluation and Survey Research, National Institute of Public Health, Cuernavaca, Morelos, Mexico  \n5Endocrinology and Metabolism Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico 6Center for Research on Policy, Population, and Health, Faculty of Medicine, National Autonomous University of Mexico, Circuito Centro Cultural s/n Edificio CIPPS, 2do piso, Ciudad Universitaria. CdMx, Mexico City, CP 04510, México  \n© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence","cbCaibaxoOjjZTPH","https://ap.wps.com/l/cbCaibaxoOjjZTPH","pdf",1580372,"English","# Abstract\n# Materials and methods\n# Results\n# Conclusions\n# Keywords\n# Introduction","[{\"question\":\"How were depressive symptoms measured in the study?\",\"answer\":\"Depressive symptoms were assessed using the CES-D7 scale.\"},{\"question\":\"What indicators defined metabolic control?\",\"answer\":\"Metabolic control was defined using glycated hemoglobin, blood pressure, and cholesterol levels.\"},{\"question\":\"What is the main finding regarding poor glycemic/metabolic control and depressive symptoms?\",\"answer\":\"Poor metabolic control was associated with a higher prevalence of depressive symptoms, especially among participants with microvascular complications.\"}]","Poor glycemic control and microvascular complications: key drivers of depressive symptoms in adults with diabetes | PDF",1790737190,25]