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This review examines epigallocatechin gallate (EGCG) and resveratrol for their anticancer activity, safety profiles, and capacity to modulate multiple signaling pathways tied to pancreatic tumorigenesis. The compounds show anti-cancer effects via epigenetic regulation, direct receptor interactions, and pathway control, including PI3K/Akt, NF-κB, p53, oxidative stress and inflammatory mediator suppression. Both enhance chemosensitivity and reduce drug resistance in preclinical models.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/polyphenols-in-pancreatic-cancer-management-exploring-the-roles-and-mechanisms-of-resveratrol-and-epigallocatechin/370881/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/polyphenols-in-pancreatic-cancer-management-exploring-the-roles-and-mechanisms-of-resveratrol-and-epigallocatechin/370881.png","ImageObject",300,407,{"name":92,"@type":93},"Jasmine","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",15,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Why are polyphenols considered adjunctive agents for pancreatic cancer treatment?","Question",{"text":113,"@type":114},"Polyphenols, especially EGCG and resveratrol, are highlighted for their ability to modulate multiple signaling pathways relevant to pancreatic tumorigenesis. The review emphasizes supportive anticancer activity and favorable safety profiles.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What key mechanisms are associated with resveratrol in pancreatic cancer?",{"text":118,"@type":114},"Resveratrol is described as modulating PI3K/Akt and Wnt signaling by inhibiting IGF-1R activation and activating the tumor suppressor p53. These actions are linked to reduced proliferation, increased apoptosis, and suppression of EMT.",{"name":120,"@type":111,"acceptedAnswer":121},"How do EGCG and resveratrol affect chemosensitivity and drug resistance?",{"text":122,"@type":114},"Both polyphenols are reported to enhance chemosensitivity and reduce resistance to conventional therapies. The review links these effects to modulation of drug transporters and apoptotic pathways.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},370881,1790520368,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":46,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":31},2336478487870,"https://ap-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","Tech Science Press  \nDoi:10.32604/or.2025.065222  \nREVIEW  \nPolyphenols in Pancreatic Cancer Management: Exploring the Roles and Mechanisms of Resveratrol and Epigallocatechin  \nDavid A de la Garza-Kalife1, Verónica L Loaiza-Gutiérrez1, Esther Alhelí Hernández-Tobías2, Carlos A González-Villarreal3, Jose Francisco Islas1, Michelle G Santoyo-Suárez1,  \nElsa N Garza-Treviño1, * and Paulina Delgado-Gonzalez1, *  \n1 Department of Biochemistry and Molecular Medicine, Faculty of Medicine, Autonomous University of Nuevo León (UANL), Monterrey, 64460, Mexico  \n2 School of Public Health and Nutrition, Autonomous University of Nuevo León (UANL), Monterrey, 64460, Mexico 3 Department of Basic Sciences, Laboratory of Molecular Genetics, University of Monterrey (UDEM), Monterrey, 66238, Mexico *Corresponding Author: Elsa N Garza-Treviño. Email: [elsa.garzatr@uanl.edu.mx](elsa.garzatr@uanl.edu.mx);  \nPaulina Delgado-Gonzalez. Email: [paulina.delgadogn@uanl.edu.mx](paulina.delgadogn@uanl.edu.mx)  \nReceived: 07 March 2025; Accepted: 16 May 2025; Published: 28 August 2025  \nABSTRACT: Emerging evidence highlights the potential of bioactive compounds, particularly polyphenols, as adjunctive therapeutic agents in the treatment of pancreatic cancer (PC), one of the most aggressive malignancies. This review focuses on epigallocatechin gallate (EGCG) and resveratrol due to their extensively documented anticancer activity, favorable safety profiles, and their unique ability to modulate multiple signaling pathways relevant to pancreatic tumorigenesis. Among polyphenols, these two have shown superior anti-cancer activity, epigenetic regulatory effects, and synergy with standard chemotherapies in preclinical pancreatic cancer models. Resveratrol exhibits antiproliferative effects by modulating key signaling pathways, including phosphatidylinositol 3 kinase (PI3K)/protein kinase B (Akt), nuclear factor kappa-B (NF-κB), and tumor protein 53 (p53) . EGCG exerts anti-cancer activity by targeting multiple cellular processes, such as oxidative stress reduction, and suppression of inflammatory mediators like Interleukin-6 (IL-6) and Tumor Necrosis Factor-α (TNF-α) . Both EGCG and resveratrol exert anti-pancreatic cancer effects partly through direct interactions with cell surface receptors and modulation of intracellular cascades. EGCG targets the 67 kDa laminin receptor (67LR), which is overexpressed in pancreatic cancer cells, triggering apoptosis, cyclic guanosine monophosphate (cGMP) production and activation of the PKCδ/acid sphingomyelinase (ASM) cascade. Resveratrol inhibits insulin-like growth factor-1 receptor (IGF-1R) activation of the PI3K/Akt and Wnt signaling pathways, while concurrently activating tumor suppressor p53. These interactions suppress proliferation, promote apoptosis, and reduce epithelial-mesenchymal transition (EMT), thereby limiting tumor progression. Both polyphenols enhance chemosensitivity and reduce resistance to conventional therapies, including gemcitabine, by modulating drug transporters and apoptotic pathways. Furthermore, their epigenetic influence, particularly via DNA methylation and histone modification, suggests a broader role in pancreatic cancer prevention. Understanding the roles and mechanisms of resveratrol and EGCG in pancreatic cancer provides valuable insights into novel treatment strategies. The integration of polyphenols into conventional therapeutic approaches may offer new hope for improving patient outcomes.  \nKEYWORDS: Pancreatic cancer (PC); polyphenols; resveratrol; epigallocatechin; bioactive compounds  \nCopyright © 2025 The Authors. Published by Tech Science Press.  \nThis work is licensed under a Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.  \n1 Introduction  \nPancreatic cancer (PC) is one of the leading causes of cancer-related death worldwide, with 510,992 new cases a","cbCaitETXEsFJjT4","https://ap.wps.com/l/cbCaitETXEsFJjT4","pdf",3667783,"English","# Abstract\n# Introduction\n## Epidemiology and clinical burden\n## Risk factors and symptoms\n## Current treatment approaches and challenges\n## Nutrition, cachexia, and metabolism\n# Bioactive dietary compounds","[{\"question\":\"Why are polyphenols considered adjunctive agents for pancreatic cancer treatment?\",\"answer\":\"Polyphenols, especially EGCG and resveratrol, are highlighted for their ability to modulate multiple signaling pathways relevant to pancreatic tumorigenesis. The review emphasizes supportive anticancer activity and favorable safety profiles.\"},{\"question\":\"What key mechanisms are associated with resveratrol in pancreatic cancer?\",\"answer\":\"Resveratrol is described as modulating PI3K/Akt and Wnt signaling by inhibiting IGF-1R activation and activating the tumor suppressor p53. These actions are linked to reduced proliferation, increased apoptosis, and suppression of EMT.\"},{\"question\":\"How do EGCG and resveratrol affect chemosensitivity and drug resistance?\",\"answer\":\"Both polyphenols are reported to enhance chemosensitivity and reduce resistance to conventional therapies. The review links these effects to modulation of drug transporters and apoptotic pathways.\"}]","Polyphenols in Pancreatic Cancer Management: Exploring the Roles and Mechanisms of Resveratrol and Epigallocatechin | PDF",1790190749]