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It outlines how WHO supports research, development, quality assurance, impact assessment, and access to vaccine technologies, including policy guidance and capacity building for countries. The manual revises and replaces an earlier WHO virological investigation manual and provides edition and ordering details plus publication information.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/polio-laboratory-manual-4th-edition-2004/501762/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/polio-laboratory-manual-4th-edition-2004/501762.png","ImageObject",300,407,{"name":92,"@type":93},"Riley West","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-11","2026-10-03",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",14,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is the purpose and scope of the Polio laboratory manual?","Question",{"text":113,"@type":114},"The manual supports polio eradication by defining the laboratory’s role and by aligning laboratory investigations with broader immunization and vaccine-preventable disease strategies.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How does WHO’s vaccine-preventable disease work relate to polio laboratory activities?",{"text":118,"@type":114},"WHO coordinates research and development, ensures vaccine quality and safety, evaluates impact to guide introductions, and helps reduce barriers to vaccines—elements that underpin effective polio eradication laboratory work.",{"name":120,"@type":111,"acceptedAnswer":121},"How is this edition positioned relative to previous WHO polio manuals?",{"text":122,"@type":114},"The document states that it revises and replaces the earlier Manual for the virological investigation of polio (WHO/EPI/GEN/97.01).","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},501762,1791156290,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146,"preview_page_count":4},1099523885074,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","The World Health Organization has managed cooperation with its Member States and provided technical support in the field of vaccine-preventable diseases since 1975. In 2003, the office carrying out this function was renamed the WHO Department of Immunization, Vaccines and Biologicals.  \nThe Department’s goal is the achievement of a world in which all people at risk are protected against vaccine-preventable diseases. Work towards this goal can be visualized as occurring along a continuum. The range of activities spans from research, development and evaluation of vaccines to implementation and evaluation of immunization programmes in countries.  \nWHO facilitates and coordinates research and development on new vaccines and immunization-related technologies for viral, bacterial and parasitic diseases. Existing life-saving vaccines are further improved and new vaccines targeted at public health crises, such as HIV/AIDS and SARS, are discovered and tested (Initiative for Vaccine Research) .  \nThe quality and safety of vaccines and other biological medicines is ensured through the development and establishment of global norms and standards (Quality Assurance and Safety of Biologicals) .  \nThe evaluation of the impact of vaccinepreventable diseases informs decisions to introduce new vaccines. Optimal strategies and activities for reducing morbidity and mortality through the use of vaccines are implemented (Vaccine Assessment and Monitoring) .  \nEfforts are directed towards reducing financialand technical barriers to the introduction of new and established vaccines and immunization-related technologies (Access to Technologies) .  \nUnder the guidance of its Member States, WHO, in conjunction with outside world experts, develops and promotes policies and strategies to maximize the use and delivery of vaccines of public health importance. Countries are supported so that they acquire the technical and managerial skills, competence and infrastructure needed to achieve disease control and/or elimination and eradication objectives (Expanded Programme on Immunization) .  \nDepartment of Immunization, Vaccines and Biologicals  \nFamily and Community Health  \nWorld Health Organization CH-1211 Geneva 27  \nSwitzerland  \nFax: +41 22 791 4227  \nEmail: [vaccines@who.int](vaccines@who.int)  \nor visit our web site at: [http://www.who.int/vaccines-documents](http://www.who.int/vaccines-documents)  \nWHO/IVB/04.10 ORIGINAL: ENGLISH  \nPolio laboratory manual  \n4th edition, 2004  \nImmunization, Vaccines and Biologicals  \nB  \nWHO/IVB/04.10 ORIGINAL: ENGLISH  \nImmunization  \nVB  \nThe Department of Immunization, Vaccines and Biologicals thanks the donors whose unspecified financial support has made the production of this document possible.  \nOrdering code: WHO/IVB/04.10  \nPrinted: November 2004  \nCopies may be requested from: World Health Organization Department of Immunization, Vaccines and Biologicals CH-1211 Geneva 27, Switzerland Fax: +41 22 791 4227; [Email:](Email: vaccines@who.int)[ ](Email: vaccines@who.int)[vaccines@who.int](Email: vaccines@who.int)  \nThis document revises and replaces the Manual for the virological investigation of polio WHO/EPI/GEN/97.01.  \n© World Health Organization 2004  \nAll rights reserved. Publications of the World Health Organization can be obtained from Marketing and Dissemination, World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland (tel:+41 22 791 2476; fax: +41 22 791 4857; email: [bookorders@who.int](bookorders@who.int)). Requests for permission to reproduce or translate WHO publications – whether for sale or for noncommercial distribution – should be addressed to Publications, at the above address (fax: +41 22 791 4806; email: [permissions@who.int](permissions@who.int)).  \nThe designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, ","cbCail6oZuQ8hj77","https://ap.wps.com/l/cbCail6oZuQ8hj77","pdf",13574957,168,"English","# Contents\n## List of figures\n## List of tables\n## Abbreviations and acronyms\n## 1. Introduction\n## 1.1 The Polio Eradication Initiative\n## 1.2 History of poliomyelitis and polio vaccines\n## 1.3 Characterization of the pathogen\n## 1.4 Transmission of poliovirus\n## 2. Role and function of the laboratory in polio eradication\n## 2.1 Appropriate investigations\n## 2.2 Structure and activities of the","[{\"question\":\"What is the purpose and scope of the Polio laboratory manual?\",\"answer\":\"The manual supports polio eradication by defining the laboratory’s role and by aligning laboratory investigations with broader immunization and vaccine-preventable disease strategies.\"},{\"question\":\"How does WHO’s vaccine-preventable disease work relate to polio laboratory activities?\",\"answer\":\"WHO coordinates research and development, ensures vaccine quality and safety, evaluates impact to guide introductions, and helps reduce barriers to vaccines—elements that underpin effective polio eradication laboratory work.\"},{\"question\":\"How is this edition positioned relative to previous WHO polio manuals?\",\"answer\":\"The document states that it revises and replaces the earlier Manual for the virological investigation of polio (WHO/EPI/GEN/97.01).\"}]","Polio laboratory manual - 4th edition - 2004 | PDF",1791024496,423]