[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-333159-105":59,"doc-detail-333159-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","point-of-care-tests-for-human-papillomavirus-detection-in-uterine-cervical-samples-a-review-of-advances","Point-of-care tests for human papillomavirus detection in uterine cervical samples - A review of advances","","Cervical cancer incidence and mortality remain elevated in resource-constrained settings due to limited infrastructure and trained personnel. HPV-based screening offers high sensitivity for detecting high-grade lesions, yet approved tests are costly and often require extensive laboratory infrastructure, delaying reporting and limiting program access. This review summarizes current and near-POC HPV testing devices, highlights technologies with potential for low-cost development, and emphasizes coordinated research to deliver easy-to-run, cost-effective tests with strong sensitivity for screening.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/point-of-care-tests-for-human-papillomavirus-detection-in-uterine-cervical-samples-a-review-of-advances/333159/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/point-of-care-tests-for-human-papillomavirus-detection-in-uterine-cervical-samples-a-review-of-advances/333159.png","ImageObject",300,407,{"name":92,"@type":93},"Patrick","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-05","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Why are point-of-care HPV tests needed in resource-constrained settings?","Question",{"text":113,"@type":114},"Approved HPV tests are often costly and depend on extensive laboratory setups and trained staff, which limits screening access. Point-of-care or near-POC testing aims to provide usable results with simpler workflows and lower cost.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What does the review focus on?",{"text":118,"@type":114},"It reviews merits and limitations of commercially available POC and near-POC devices for HPV-based cervical screening, and highlights technologies that could enable future low-cost POC tests.",{"name":120,"@type":111,"acceptedAnswer":121},"How were studies selected for inclusion?",{"text":122,"@type":114},"A systematic search was conducted from January 1, 2004 to December 31, 2022 using terms related to cervical cancer, HPV, screening, point-of-care testing, near-patient testing, evaluation, and performance. Included studies described POC or near-POC HPV detection (DNA or RNA) for cervical cancer screening.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},333159,1790138958,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146,"preview_page_count":4},549758146520,"https://ap-avatar.wpscdn.com/avatar/80002397d8c0411e94?_k=1775819394049821470","Indian J Med Res 158, November & December, 2023, pp 509-521 DOI: 10.4103/ijmr.ijmr_ 1143_23  \nReview Article  \n\n| Quick Response Code: |\n| --- |\n| |\n\nPoint-of-care tests for human papillomavirus detection in uterine cervical samples: Areview of advances in resource-constrained settings  \nRuchika Gupta & Sanjay Gupta  \nDivision of Cytopathology, ICMR-National Institute for Cancer Prevention and Research, Noida, Uttar Pradesh, India  \nReceived June 13, 2023  \nIncidence of cervical cancer and associated mortality are still high in resource-constrained countries due to the lack of infrastructural facilities and trained workforce. Human papillomavirus (HPV)-based screening tests offer a better sensitivity (>90%) for the detection of cervical high-grade lesions. However, these tests usually require an extensive laboratory set-up and trained technical staff. Moreover, the high cost of the currently available and approved HPV tests precludes their use in the cervical cancer screening programmes in resource-limited settings. Hence, there is a felt need for a low-cost point-ofcare (POC) HPV test with good performance characteristics to help augment cervical cancer screening in such settings. A recent meta-analysis demonstrated a good sensitivity and specificity for two of the commercially available POC HPV tests. The present review discusses the merits and limitations of the current commercially available POC and near-POC devices for HPV-based cervical cancer screening.  \nThe technologies that have the potential to be developed into low-cost POC tests and newer promising modalities for HPV-based POC or near POC have also been highlighted. This review underscores the need for collaborative and coordinated research for development of POC or near-POC HPV-based tests to be used in cervical cancer screening. Efforts need to be focussed on technologies that offer ease of performance without the requirement of sophisticated equipment or extensive sample pre-processing  \ncoupled with a good sensitivity and cost-effectiveness.  \nKey words Cervical cancer screening-HPV DNA detection-near point-of-care-point-of-care  \nHuman papillomavirus (HPV) is the causative agent of cervical precancerous lesions and cancer1. Currently, there are six US-FDA-approved assays for HPV detection (DNA or RNA) for use in cervical cancer screening2. In addition, the International HPV Laboratory Network conducts proficiency testing for laboratories using commercially available HPV-based tests as well as the in-house assays3. However, the costintensiveness of these assays, the requirement of an  \nextensive laboratory set-up with high-end equipment and the delay in report generation (usually due to the batch system of sample processing) have hindered the utility and application of HPV-based cervical cancer screening in the low- and low-middle income countries4. Hence, there has been a felt need for the development of cost-effective point-of-care (POC) or near-POC methods for HPV detection in cervical samples. Alongside this, there has been a growing  \n© 2023 Indian Journal of Medical Research, published by Wolters Kluwer-Medknow for Director-General, Indian Council of Medical Research  \n510 INDIAN J MED RES, NOVEMBER & DECEMBER 2023  \ninterest in the evaluation of the self-sampling of vaginal samples for HPV-based cervical cancer screening to expand the coverage of screening. Studies have reported a comparable sensitivity across self-collected vaginal samples as well as physician-collected samples for the detection of cervical precancerous lesions5,6 . The coupling of low-cost POC or near-POC HPV tests with self-sampling can offer the best opportunity to resource-constrained nations for cervical cancer elimination. However, a few studies have reported a lack of awareness (of cervical cancer as well as the importance of screening), social influence, religious reasons and partner’s disapproval as barriers for women not consenting to participate in self-sampling for the HPV-","cbCaieO6ciAACFe9","https://ap.wps.com/l/cbCaieO6ciAACFe9","pdf",1240458,13,"English","# Methods\n## Search strategy\n## Inclusion criteria\n## Performance considerations","[{\"question\":\"Why are point-of-care HPV tests needed in resource-constrained settings?\",\"answer\":\"Approved HPV tests are often costly and depend on extensive laboratory setups and trained staff, which limits screening access. Point-of-care or near-POC testing aims to provide usable results with simpler workflows and lower cost.\"},{\"question\":\"What does the review focus on?\",\"answer\":\"It reviews merits and limitations of commercially available POC and near-POC devices for HPV-based cervical screening, and highlights technologies that could enable future low-cost POC tests.\"},{\"question\":\"How were studies selected for inclusion?\",\"answer\":\"A systematic search was conducted from January 1, 2004 to December 31, 2022 using terms related to cervical cancer, HPV, screening, point-of-care testing, near-patient testing, evaluation, and performance. Included studies described POC or near-POC HPV detection (DNA or RNA) for cervical cancer screening.\"}]","Point-of-care tests for human papillomavirus detection in uterine cervical samples - A review of advances | PDF",1790001197,33]