[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-353029-105":59,"doc-detail-353029-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","platelets-induce-vista-expression-and-modulate-the-ovarian-tumor-microenvironment","Platelets induce VISTA expression and modulate the ovarian tumor microenvironment","","Immune checkpoint regulators, including VISTA, shape the ovarian tumor microenvironment and enable immune evasion. In ovarian cancer, VISTA shows more abundant and consistent expression than other checkpoints such as PD-L1. The study evaluates how platelets regulate VISTA using in vitro and in vivo models, showing platelet-driven upregulation of VISTA in myeloid and tumor cells. Higher VISTA correlates with elevated platelet counts and worse clinical outcomes, supporting platelet-mediated VISTA as a therapeutic target to improve antitumor immunity.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/platelets-induce-vista-expression-and-modulate-the-ovarian-tumor-microenvironment/353029/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/platelets-induce-vista-expression-and-modulate-the-ovarian-tumor-microenvironment/353029.png","ImageObject",300,407,{"name":92,"@type":93},"eBook King","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-23","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What role does VISTA play in the ovarian tumor microenvironment?","Question",{"text":112,"@type":113},"VISTA is an immune checkpoint regulator that helps shape an immunosuppressive tumor microenvironment and facilitates immune evasion.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How do platelets affect VISTA expression in ovarian cancer?",{"text":117,"@type":113},"Platelets upregulate VISTA expression in both myeloid and tumor cells, promoting an immunosuppressive tumor microenvironment.",{"name":119,"@type":110,"acceptedAnswer":120},"What clinical associations were observed for VISTA and platelet levels?",{"text":121,"@type":113},"Elevated VISTA levels were associated with higher platelet counts and poorer clinical outcomes.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},353029,1790195194,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":46,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":31},962088006270,"https://ap-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","Author Manuscript Author Manuscript Author Manuscript Author Manuscript  \n\n| | HHS Public Access\u003Cbr>Author manuscript\u003Cbr>Platelets. Author manuscript; available in PMC 2026 June 03. |\n| --- | --- |\n\nPublished in final edited form as:  \nPlatelets. 2026 December 31; 37(1): 2644366. doi:10.1080/09537104.2026.2644366 .  \nPlatelets induce VISTA expression and modulate the ovarian tumor microenvironment  \nHani Lee 1 , Brianne Sager1 , Anil Sood2 , Vahid Afshar-Kharghan 1 , Min Soon Cho 1  \n1The Section of Benign Hematology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;  \n2The Department of Gynecology Oncology & Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA  \nAbstract  \nImmune checkpoint regulators, such as the V-domain Ig suppressor ofT cell activation (VISTA), play a critical role in shaping the tumor microenvironment (TME) and facilitating immune evasion. In ovarian cancer, VISTA exhibits more abundant and consistent expression than other immune checkpoints, including Programmed Death-Ligand 1 (PD-L1) . This study examined the role of platelets in the regulation of VISTA in ovarian cancer using both in vitro and in vivo models. Our findings demonstrate that platelets upregulate VISTA expression in both myeloid and tumor cells, thereby promoting an immunosuppressive TME. Elevated VISTA levels were associated with higher platelet counts and poorer clinical outcomes. These results highlight that platelet-mediated VISTA upregulation is a potential therapeutic target for improving antitumor immune responses in ovarian cancer.  \nKeywords  \nImmune checkpoint; neutrophils; ovarian cancer; platelet  \nIntroduction  \nOvarian cancer remains a leading cause of gynecologic cancer-related deaths 1, marked by a profoundly immunosuppressive tumor microenvironment (TME) . Despite advancesin treatment, the prognosis of advanced ovarian cancer remains poor, primarily due to chemotherapy-refractory relapses and resistance to immunotherapy.2,3 The interplay  \nThis is an Open Access article distributed under the terms of the Creative Commons Attribution License ([http://creativecommons.org/](http://creativecommons.org/)[ ](http://creativecommons.org/)[licenses/by/4.0/](licenses/by/4.0/)), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.  \n✉[CONTACT Vahid Afshar-Kharghan vakharghan@mdanderson.org](CONTACT Vahid Afshar-Kharghan vakharghan@mdanderson.org); Min Soon Cho choms8932@gmail.com The Section of Benign Hematology, The University of Texas MD Anderson Cancer Center, 5660, MD Anderson Blvd, Z9.5044, Houston, TX 77025, USA. Disclosure statement  \nNo potential conflict of interest was reported by the author(s) .  \nConflict of interest declaration  \nThe authors declare that they have no affiliations with or involvement in any organization or entity with any financial interest in the subject matter or material discussed in this manuscript.  \nAuthor Manuscript Author Manuscript Author Manuscript Author Manuscript  \nLee et al. Page 2  \nbetween cancer cells, immune cells, and stromal cells within the TME shapes the immune response and drives disease progression.4,5 Immune checkpoint proteins, such as PD-L1 and V-domain Ig suppressor ofT cell activation (VISTA), are central to this regulatory network, suppressing antitumor immunity.6 We have previously shown that platelets contribute to immune modulation within the TME, upregulate PD-L1 expression, and influence the efficacy of anti-PD-L1 immunotherapy in murine models of ovarian cancer.7  \nVISTA has recently emerged as a critical regulator of immune suppression in the TME, particularly through its activity on myeloid cells, which inhibits T-cell activation and facilitates immune evasion.8–13 In high-grade serous ovaria","cbCaivRkIo5Imy6Y","https://ap.wps.com/l/cbCaivRkIo5Imy6Y","pdf",2034207,"English","# Abstract\n# Introduction\n# Materials and methods","[{\"question\":\"What role does VISTA play in the ovarian tumor microenvironment?\",\"answer\":\"VISTA is an immune checkpoint regulator that helps shape an immunosuppressive tumor microenvironment and facilitates immune evasion.\"},{\"question\":\"How do platelets affect VISTA expression in ovarian cancer?\",\"answer\":\"Platelets upregulate VISTA expression in both myeloid and tumor cells, promoting an immunosuppressive tumor microenvironment.\"},{\"question\":\"What clinical associations were observed for VISTA and platelet levels?\",\"answer\":\"Elevated VISTA levels were associated with higher platelet counts and poorer clinical outcomes.\"}]","Platelets induce VISTA expression and modulate the ovarian tumor microenvironment | PDF",1790102655]