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Retrospective data from AIS patients treated at Thammasat University Hospital between January 2018 and June 2021 were analyzed for 90-day outcomes, including early and delayed neurological deterioration and hemorrhagic transformation. Among 434 patients, higher versus lower PNR groups showed statistically different endpoints, and PNR was independently associated with worse 3-month functional outcome and adverse neurological events.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/platelet-to-neutrophil-ratio-as-a-prognostic-marker-after-intravenous-thrombolysis-in-acute-ischemic-stroke-journal-article/510838/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/platelet-to-neutrophil-ratio-as-a-prognostic-marker-after-intravenous-thrombolysis-in-acute-ischemic-stroke-journal-article/510838.png","ImageObject",300,407,{"name":92,"@type":93},"Stanley","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-12","2026-10-06",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the platelet-to-neutrophil ratio (PNR) in this study?","Question",{"text":112,"@type":113},"PNR is a biomarker calculated by combining platelet and neutrophil counts to reflect both thrombosis and inflammation in acute ischemic stroke.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was PNR used to predict outcomes after intravenous thrombolysis?",{"text":117,"@type":113},"Patients were grouped into high or low PNR based on receiver operating curve (ROC) cut-off values for each endpoint, and endpoints included END, HT, DND, and poor 3-month outcome (mRS ≥ 3).",{"name":119,"@type":110,"acceptedAnswer":120},"What associations did the study find between PNR and clinical outcomes?",{"text":121,"@type":113},"Lower PNR independently predicted worse 3-month functional outcome and was associated with hemorrhagic transformation and delayed neurological deterioration.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},510838,1791460539,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":41,"preview_page_count":4},2336477405376,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","Vol.39 • NO.1 • 2023  41   \nAbstract  \nIntroduction: Platelet-to-neutrophil ratio (PNR) is a new biomarker that combines platelets and neutrophil counts. A recent study suggested that the level of PNR on admission is associated with the prognosis of acute ischemic stroke (AIS) patients.  \nObjective: To investigate PNR value as a prognostic marker for 90-days outcomes in AIS patients after intravenous thrombolysis.  \nMaterial and Method: Data on AIS patients who received intravenous thrombolysis treatment from January 2018 to June 2021 were collected at Thammasat University Hospital. Clinical outcome indicators included early neurological deterioration (END), hemorrhagic transformation (HT), delayed neurological deterioration (DND), and poor 3-month outcome (3m-mRS ³ 3) .  \nResults: A total 434 patients were analyzed in this study. The age was 64.5 (53-72) years, and 249 (59 .6%) were male. PNR level was identified as high (at the cut-off value or above) or low (below the cut-off value) according to receiver operating curve (ROC) analyses on each endpoint.  \nComparison of hemorrhagic transformation (HT)  \ndelayed neurological deterioration (DND), and poor 3-month outcome (3m-mRS ³ 3) between patients at high and low levels for platelet-toneutrophil ratio (PNR) showed statistical differences (p \u003C 0.05) .  \nConclusion: PNR was independently associated with poor 3-month outcome (mRS ³ 3), hemorrhagic transformation and delay neurological deterioration. Lower PNR can predict a worse outcome.  \nKeywords: Stroke, Thailand, Platelet, Neutrophil, Ratio, Outcome  \natelet-toio afterI-Neutntravre Thrombolysis is  \nPr-ndoasytcMarOutcermeforin Acute Ischemic Stroke  \nAusanee Chaiwisitkun, Sombat Muengtaweepongsa  \nAusanee Chaiwisitkun, Sombat Muengtaweepongsa Neurology Division, Department of Internal Medicine,  \nFaculty of Medicine, Thammasat University Rangsit Campus, Klongluang, Pathumthani, Thailand  \nCorresponding author: Ausanee Chaiwisitkun  \nNeurology Division, Department of Internal Medicine, Faculty of Medicine, Thammasat University Rangsit Campus, Klongluang, Pathumthani, Thailand  \nE-mail: [a.chaiwisitkun@gmail.com](a.chaiwisitkun@gmail.com)  \nReceived: July 12, 2022, Revised: October 7, 2022, Accepted for publication: October 10, 2022  \n 42 วารสารประสาทวิทยาแห่งประเทศไทย Vol.39 • NO.1 • 2023   \nIntroduction  \nStroke is the second leading cause of death worldwide and also the leading cause of long-term disability. Ischemic stroke is the most common typeof stroke.1 An occurrence of acute ischemic stroke (AIS) always leads to the death of brain tissues and focal neurological deficits. The World Health Organization (WHO) estimates that every year there will be more than 15 million stroke patients worldwide, and by 2020 this will double.2 Thailand situation in the past 5 years of the Department of Strategic and Planning, Ministry of Public Health (2013-2017), the number of stroke cases tends to increase every year. In 2017, there were 304,807 new cases and deaths more than 30,000 cases last year.3 Recombinant tissue plasminogen activator (rtPA) is the only thrombolytic agent approved by the FDA for ischemic stroke therapy.4 But, owing to the limitation of the narrow therapeutic time window (4 .5 h from the onset of symptoms of ischemic stroke) and the potential risk of hemorrhagic transformation (HT), only partial patients can benefit from intravenous thrombolysis (IVT) .  \nIn the pathogenesis of AIS, platelet activation and aggregation are important. Under pathological conditions, excessive activation and aggregation of platelets may lead to thrombosis and vascular occlusion, which would result in ischemic stroke.5 Numerous studies have demonstrated that platelet count (PLT) decreases in the circulatory system of AIS patients, whereas platelet distribution width (PDW) and mean platelet volume (MPV) increase.6 It is known that the immune response is vital in the pathological changes of AIS. Ischemic and anoxic brain tissue promote t","cbCaigqaqySw8eAV","https://ap.wps.com/l/cbCaigqaqySw8eAV","pdf",341819,12,"English","# Introduction\n## Platelet and neutrophil roles in AIS\n# Materials and Methods\n## Study population and criteria\n## Data collection\n# Results\n## Patient characteristics and PNR grouping\n# Conclusion","[{\"question\":\"What is the platelet-to-neutrophil ratio (PNR) in this study?\",\"answer\":\"PNR is a biomarker calculated by combining platelet and neutrophil counts to reflect both thrombosis and inflammation in acute ischemic stroke.\"},{\"question\":\"How was PNR used to predict outcomes after intravenous thrombolysis?\",\"answer\":\"Patients were grouped into high or low PNR based on receiver operating curve (ROC) cut-off values for each endpoint, and endpoints included END, HT, DND, and poor 3-month outcome (mRS ≥ 3).\"},{\"question\":\"What associations did the study find between PNR and clinical outcomes?\",\"answer\":\"Lower PNR independently predicted worse 3-month functional outcome and was associated with hemorrhagic transformation and delayed neurological deterioration.\"}]","Platelet-to-Neutrophil Ratio as a Prognostic Marker After Intravenous Thrombolysis in Acute Ischemic Stroke - Journal Article | PDF",1791245481]