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Standardized mean difference (SMD) with 95% confidence intervals was calculated using a random-effects model, and pooled results showed elevated VWF in patients and an association with metastasis.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/plasma-von-willebrand-factor-levels-in-patients-with-cancer-a-meta-analysis/333508/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/plasma-von-willebrand-factor-levels-in-patients-with-cancer-a-meta-analysis/333508.png","ImageObject",300,407,{"name":42,"@type":43},"Violet","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",13,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What was the aim of the meta-analysis?","Question",{"text":63,"@type":64},"To clarify the association between plasma von Willebrand factor levels and cancer incidence and metastasis.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were studies selected and how many participants were included?",{"text":68,"@type":64},"A comprehensive search covered multiple databases from inception to March 3, 2023, selecting 15 original studies with a total of 1,403 individuals.",{"name":70,"@type":61,"acceptedAnswer":71},"What statistical approach was used to evaluate the results?",{"text":72,"@type":64},"Standardized mean difference (SMD) with 95% confidence intervals was estimated using a random-effects model.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},333508,1790032309,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,111,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":108,"show_sort_weight":109,"slug":110},7,"Healthcare",40,"healthcare",{"id":112,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":113,"slug":114},8,30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":112,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":116,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145,"preview_page_count":4},4398048950312,"https://ap-avatar.wpscdn.com/avatar/400002538284de19e3c?_k=1778320343897328908","ONCOLOGY LETTERS 28: 399, 2024  \nPlasma von Willebrand factor levels in patients with cancer:  \nA meta‑analysis  \nXITAN WANG 1,2 , XIAOYU ZHANG3 , CHAONAN ZHANG 1,2 , LI QI4 and JU LIU 1,2  \n1School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong 261053, P.R. China; 2Institute of Microvascular Medicine, Medical Research Center, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong 250014, P.R. China; 3Department of Medical Physiology, School of Basic Medical Sciences, Shandong Second Medical University, Weifang, Shandong 261053,  \n4  \nP.R. China; Department of Infectious Diseases, Affiliated Hospital of Shandong Second Medical University,  \nWeifang, Shandong 261053, P.R. China  \nReceived February 6, 2024; Accepted June 17, 2024  \nDOI: 10. 3892/ol.2024.14532  \nAbstract. von Willebrand Factor (VWF) is well recognized for being dysregulated in various malignancies and has emerged as a potential biomarker for cancer detection . The present meta‑analysis aimed to elucidate the association between plasma VWF and the incidence and metastasis of cancer. For this purpose, a comprehensive search was conducted across multiple databases from their inception until March 3, 2023. This culminated in the selection of 15 original studies on various types of cancer, including a collective sample of 1,403 individuals. The standardized mean difference (SMD) and 95% confidence intervals (CIs) were employed as statistical parameters to determine the association between plasma VWF and the incidence and metastasis of cancer. These were estimated using a random‑effects model. The pooled data revealed that the plasma VWF levels of patients with cancer were significantly elevated compared with those of healthy controls (SMD, 0.98; 95% CI, 0.59‑1.36), and a significant asso‑ ciation was observed between plasma VWF levels and cancer metastasis (SMD, 0.69; 95% CI, 0.33‑1.06) . The symmetry of the Begg's funnel plots indicated that no significant bias was present in the analyses of VWF in cancer and its metastasis.  \nCorrespondence to: Professor Li Qi, Department of Infectious Diseases, Affiliated Hospital of Shandong Second Medical University, 2428 Yuhe Road, Weifang, Shandong 261053, P.R. China  \nE‑mail: [ql1104@126.com](ql1104@126.com)  \nProfessor Ju Liu, Institute of Microvascular Medicine, Medical Research Center, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, 16766 Jingshi Road, Jinan, Shandong 250014, P.R. China  \nE‑mail: [ju.liu@sdu.edu.cn](ju.liu@sdu.edu.cn)  \nAbbreviations: VWF, von Willebrand factor; SMD, standard mean difference; CI, confidence interval; EC, endothelial cell  \nKey words: VWF, plasma, cancer, meta‑analysis  \nIn summary, the results of the present meta‑analysis support the hypothesis that increased plasma VWF levels may serve asa biomarker for cancer and metastatic progression.  \nIntroduction  \nvon Willebrand factor (VWF) is a large, complex glycopro‑ tein, predominantly synthesized in endothelial cells (ECs) and megakaryocytes (1,2). VWF is released via synthetic pathways or regulatory mechanisms associated with secretory storage and subsequent discharge (3,4). Although platelets also release VWF, plasma VWF mostly originates from ECs (5) . A consid‑ erable quantity of VWF within ECs is compartmentalized in Weibel‑Palade bodies, from which it is released into the vascular lumen in response to a range of stimuli (6,7) . Once in the bloodstream, the primary function of VWF is to facilitate hemostasis. This is primarily accomplished by its strong inter‑ action with platelet receptor glycoprotein Ib (GPIb) and various constituents of the subendothelial connective tissue (8,9) . Furthermore, VWF binds to another clotting protein, factor VIII, and serves as its carrier in the blood circulation (10) . Previous studies have demonstrated that VWF is a pivotal regulator in multip","cbCaijU8TodWN7kg","https://ap.wps.com/l/cbCaijU8TodWN7kg","pdf",1926429,"English","# Abstract\n# Introduction","[{\"question\":\"What was the aim of the meta-analysis?\",\"answer\":\"To clarify the association between plasma von Willebrand factor levels and cancer incidence and metastasis.\"},{\"question\":\"How were studies selected and how many participants were included?\",\"answer\":\"A comprehensive search covered multiple databases from inception to March 3, 2023, selecting 15 original studies with a total of 1,403 individuals.\"},{\"question\":\"What statistical approach was used to evaluate the results?\",\"answer\":\"Standardized mean difference (SMD) with 95% confidence intervals was estimated using a random-effects model.\"}]","Plasma von Willebrand factor levels in patients with cancer - A meta-analysis | PDF",1790002812,23]