[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-331898-105":59,"doc-detail-331898-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","plasma-metabolites-and-risk-of-seven-cancers-a-two-sample-mendelian-randomization-study-among-european-descendants","Plasma metabolites and risk of seven cancers - a two-sample Mendelian randomization study among European descendants","","Plasma metabolite profiles are increasingly linked to cancer risk, yet the causal mechanisms behind these associations remain insufficiently tested. A two-sample Mendelian randomization study evaluated potential causal effects of 913 genetically proxied plasma metabolites on seven cancer risks in European-ancestry individuals. Genome-wide association data for metabolites and cancers were integrated, primary inference used inverse variance-weighted analysis, and results were scrutinized with sensitivity methods and replication in an independent metabolite dataset.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/plasma-metabolites-and-risk-of-seven-cancers-a-two-sample-mendelian-randomization-study-among-european-descendants/331898/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/plasma-metabolites-and-risk-of-seven-cancers-a-two-sample-mendelian-randomization-study-among-european-descendants/331898.png","ImageObject",300,407,{"name":92,"@type":93},"Anda","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the goal of the two-sample Mendelian randomization study?","Question",{"text":112,"@type":113},"To assess potential causal relationships between genetically proxied plasma metabolites and the risk of seven cancers in European-ancestry individuals.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were the metabolite and cancer genetic associations obtained?",{"text":117,"@type":113},"Metabolite associations came from a GWAS of plasma metabolites, while cancer associations were taken from large-scale GWAS consortia across seven cancer types.",{"name":119,"@type":110,"acceptedAnswer":120},"What did the study find about causal metabolite-cancer links?",{"text":121,"@type":113},"The analysis identified 94 significant associations, implying putative causal links between 66 distinct plasma metabolites and seven cancer risks, with further checks and replication supporting consistent patterns.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331898,1790177294,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":36,"preview_page_count":4},962075006959,"https://ap-avatar.wpscdn.com/avatar/e0002397efbe92a78e?_k=1776741047341049297","Chen et al. BMC Medicine (2024) 22:90 [https://doi.org/10.1186/s12916-024-03272-8](https://doi.org/10.1186/s12916-024-03272-8)  \nBMC Medicine  \n RESEARCH ARTICLE Open Access  \nPlasma metabolites and risk of seven cancers: a two-sample Mendelian randomization study among European descendants  \nYaxin Chen1,2, Yufang Xie2, Hang Ci1, Zhengpei Cheng3, Yongjie Kuang4, Shuqing Li1, Gang Wang5, Yawen Qi1, Jun Tang1, Dan Liu2, Weimin Li1,2* andYaohua Yang3*  \nAbstract  \nBackground While circulating metabolites have been increasingly linked to cancer risk, the causality underlying these associations remains largely uninterrogated.  \nMethods We conducted a comprehensive 2-sample Mendelian randomization (MR) study to evaluate the potential causal relationship between 913 plasma metabolites and the risk of seven cancers among European-ancestry individuals. Data on variant-metabolite associations were obtained from a genome-wide association study (GWAS) of plasma metabolites among 14,296 subjects. Data on variant-cancer associations were gathered from large-scale GWAS consortia for breast (N = 266,081), colorectal (N = 185,616), lung (N = 85,716), ovarian (N = 63,347), prostate (N = 140,306), renal cell (N = 31,190), and testicular germ cell (N = 28,135) cancers. MR analyses were performed with the inverse variance-weighted (IVW) method as the primary strategy to identify significant associations at Bonferroni-corrected P \u003C 0.05 for each cancer type separately. Significant associations were subjected to additional scrutiny via weighted median MR, Egger regression, MR-Pleiotropy RESidual Sum and Outlier (MR-PRESSO), and reverse MR analyses. Replication analyses were performed using an independent dataset from a plasma metabolite GWAS including 8,129 participants of European ancestry.  \nResults We identified 94 significant associations, suggesting putative causal associations between 66 distinct plasma metabolites and the risk of seven cancers. Remarkably, 68 . 2%(45) of these metabolites were each associated with the risk of a specific cancer. Among the 66 metabolites, O-methylcatechol sulfate and 4-vinylphenol sulfate demonstrated the most pronounced positive and negative associations with cancer risk, respectively. Genetically proxied plasma levels of these two metabolites were significantly associated with the risk of lung cancer and renal cell cancer, with an odds ratio and 95% confidence interval of 2.81 (2 .33–3. 37) and 0.49 (0 .40–0. 61), respectively. None of these 94 associations was biased by weak instruments, horizontal pleiotropy, or reverse causation. Further, 64 of these 94 were eligible for replication analyses, and 54 (84 .4%) showed P \u003C 0.05 with association patterns consistent with those shown in primary analyses.  \n*Correspondence: Weimin Li [weimi003@scu.edu.cn](weimi003@scu.edu.cn)[ ](weimi003@scu.edu.cn)Yaohua Yang [vta8we@virginia.edu](vta8we@virginia.edu)  \nFull list of author information is available at the end of the article  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creativecommons.org/licenses/by/4.0/](http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ()[. The Creative Commons Public Do","cbCaiuiJAkozfhG2","https://ap.wps.com/l/cbCaiuiJAkozfhG2","pdf",1993205,16,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusions\n# Background","[{\"question\":\"What was the goal of the two-sample Mendelian randomization study?\",\"answer\":\"To assess potential causal relationships between genetically proxied plasma metabolites and the risk of seven cancers in European-ancestry individuals.\"},{\"question\":\"How were the metabolite and cancer genetic associations obtained?\",\"answer\":\"Metabolite associations came from a GWAS of plasma metabolites, while cancer associations were taken from large-scale GWAS consortia across seven cancer types.\"},{\"question\":\"What did the study find about causal metabolite-cancer links?\",\"answer\":\"The analysis identified 94 significant associations, implying putative causal links between 66 distinct plasma metabolites and seven cancer risks, with further checks and replication supporting consistent patterns.\"}]","Plasma metabolites and risk of seven cancers - a two-sample Mendelian randomization study among European descendants | PDF",1789995657]