[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-426903-105":59,"doc-detail-426903-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","plasma-glial-fibrillary-acidic-protein-and-p-tau217-potential-biomarkers-of-delirium-in-older-adults-journal-article","PLASMA GLIAL FIBRILLARY ACIDIC PROTEIN AND P-TAU217: POTENTIAL BIOMARKERS OF DELIRIUM IN OLDER ADULTS - Journal Article","","Delirium is a common hospitalization complication in older adults, linked to later cognitive decline, yet its mechanisms remain poorly understood. Because delirium and dementia are interrelated, this study evaluates blood biomarkers relevant to Alzheimer’s disease pathology and neural injury. Plasma GFAP and p-Tau217 were measured before elective surgery, then delirium incidence and severity were assessed post-operatively using CAM and CAM-S.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/plasma-glial-fibrillary-acidic-protein-and-p-tau217-potential-biomarkers-of-delirium-in-older-adults-journal-article/426903/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/plasma-glial-fibrillary-acidic-protein-and-p-tau217-potential-biomarkers-of-delirium-in-older-adults-journal-article/426903.png","ImageObject",300,407,{"name":92,"@type":93},"nayy☆","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-22","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the study objective regarding delirium in older adults?","Question",{"text":112,"@type":113},"To evaluate whether blood biomarkers for Alzheimer’s disease and neural injury could provide insight into potential mechanisms underlying delirium.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were delirium incidence and severity assessed after surgery?",{"text":117,"@type":113},"Delirium incidence and severity were assessed using the Confusion Assessment Method (CAM) and CAM-S, respectively.",{"name":119,"@type":110,"acceptedAnswer":120},"Which biomarker showed a stronger association with delirium?",{"text":121,"@type":113},"High pre-operative plasma GFAP was associated with higher delirium incidence and severity, while p-Tau217 was associated only with severity; overall GFAP appeared stronger.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},426903,1790958189,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":81},962090893153,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","Innovation in Aging, 2025, Vol. 9, No. S2 313  \nAbstract citation ID: igaf122.1055  \nPLASMA GLIAL FIBRILLARY ACIDIC PROTEIN AND  \nP-TAU217: POTENTIAL BIOMARKERS OF DELIRIUM  \nIN OLDER ADULTS  \nTamara Fong1, Julianna Liu2, Edward Marcantonio3, Richard Jones4, Long Ngo3, Sarinnapha Vasunilashorn3, and Sharon Inouye5, 1. Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States, 2. University of Rochester Medical Center, Rochester, New York, United States, 3. Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States, 4. Brown University, Brown University, Rhode Island, United States, 5. Marcus Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School, Boston, Massachusetts, United States  \nObjective: Delirium is a common complication of hospitalization among older adults, and is associated with cognitive decline, but the underlying mechanisms are poorly understood.  \nDelirium and dementia are closely interrelated; therefore, blood biomarkers for Alzheimer’s disease (AD) and neural injury may yield insight to potential mechanisms in delirium. Methods: Data were obtained from the Successful Aging after Elective Surgery (SAGES) study (n = 530) . Glial fibrillary acidic protein (GFAP), a marker of reactive astrocytosis elevated in neurodegeneration and neural injury, and tau phosphorylated at residue 217 (p-Tau217), a marker of AD pathology, were measured from plasma collected prior to surgery. Post-operative delirium incidence and severity were assessed using the Confusion Assessment Method (CAM) and CAM-S (0-19, 19 worst), respectively.  \nResults: Higher GFAP (4th vs. 1st quartile) was associated with delirium incidence (relative risk (RR) 1.7, 95% confidence interval (CI): 1.1-2.8) and greater CAM-S severity (adjusted mean difference=0.5, 95% CI: 0.1-1.0). p-Tau217 did not significantly predict delirium incidence, though higher levels were associated with greater severity (adjusted mean CAM-S difference 1st to 4th quartile=0.6, 95% CI: 0.1-1.0) . Interpretation: High pre-operative plasma GFAP was associated with higher delirium incidence and severity, whereas high p-Tau217 was associated only with higher severity. Overall, GFAP appears to be a stronger risk marker than p-Tau217 for delirium. Further work is needed to establish whether astrocytosis contributes to delirium pathophysiology.","cbCaijOzcetfQ14u","https://ap.wps.com/l/cbCaijOzcetfQ14u","pdf",325397,"English","# Objective\n## Methods\n## Results\n## Interpretation","[{\"question\":\"What was the study objective regarding delirium in older adults?\",\"answer\":\"To evaluate whether blood biomarkers for Alzheimer’s disease and neural injury could provide insight into potential mechanisms underlying delirium.\"},{\"question\":\"How were delirium incidence and severity assessed after surgery?\",\"answer\":\"Delirium incidence and severity were assessed using the Confusion Assessment Method (CAM) and CAM-S, respectively.\"},{\"question\":\"Which biomarker showed a stronger association with delirium?\",\"answer\":\"High pre-operative plasma GFAP was associated with higher delirium incidence and severity, while p-Tau217 was associated only with severity; overall GFAP appeared stronger.\"}]","PLASMA GLIAL FIBRILLARY ACIDIC PROTEIN AND P-TAU217: POTENTIAL BIOMARKERS OF DELIRIUM IN OLDER ADULTS - Journal Article | PDF",1790642145]