[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-443177-105":59,"doc-detail-443177-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","planning-renal-replacement-therapy-in-factor-vii-deficiency-letter-to-the-editor","Planning Renal Replacement Therapy in Factor VII Deficiency - Letter to the Editor","","Letter to the editor addressing renal replacement therapy selection in patients with congenital coagulation factor deficiencies who develop end-stage kidney disease. It compares dialysis feasibility under factor replacement and highlights bleeding risks with surgery and hemodialysis. A 43-year-old woman with factor 7 deficiency is managed with percutaneous peritoneal dialysis catheter placement, supported by periprocedural hemostasis, without complications over one year. Table 1 contrasts percutaneous versus laparoscopic/surgical PD catheter insertion, and supplementary materials outline planning strategies.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/planning-renal-replacement-therapy-in-factor-vii-deficiency-letter-to-the-editor/443177/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/planning-renal-replacement-therapy-in-factor-vii-deficiency-letter-to-the-editor/443177.png","ImageObject",300,407,{"name":92,"@type":93},"Olivia Brown","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-03","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is choosing renal replacement therapy challenging in factor VII deficiency patients?","Question",{"text":112,"@type":113},"End-stage kidney disease occurs increasingly in congenital coagulation factor deficiency as patients live longer, but dialysis modality selection remains clinically difficult due to high bleeding risks during surgical interventions and treatment-related procedures.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What dialysis option was considered safer for the reported patient and why?",{"text":117,"@type":113},"Peritoneal dialysis was considered safer because bleeding episodes were uncommon and factor replacement was generally only needed during catheter insertion, unlike hemodialysis where repeated access procedures may require additional factor infusions.",{"name":119,"@type":110,"acceptedAnswer":120},"What does Table 1 compare regarding peritoneal dialysis catheter insertion?",{"text":121,"@type":113},"Table 1 compares pros and cons of percutaneous insertion versus laparoscopic/surgical insertion, including anesthesia needs, recovery time, the ability to directly observe abdominal structures, and recovery duration.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},443177,1791075807,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":14,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":24,"preview_page_count":4},16904993612988,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","LETTER TO THE EDITOR  \nPlanning Renal Replacement Therapy in Factor VII Deficiency  \nTo the Editor: With advances in long-term treatment strategies, patients with congenital coagulation factor deficiencies (i.e., hemophilia) are living longer but increasingly developing end-stage kidney disease. 1,2 Selecting an optimal renal replacement therapy in this population remains clinically challenging.  \nAlthough successful renal transplantation has been reported in patients with hemophilia under adequate factor replacement therapy,3 surgical interventions continue to carry substantial bleeding risks. Hemodialysis may be feasible; however, repeated arteriovenous fistula cannulation often necessitates postdialysis factor infusions to achieve hemostasis, increasing both the cost and potential for inhibitor development.4, 5 Peritoneal dialysis (PD) may be preferable, because bleeding episodes are uncommon and factor replacement is generally required only during catheter insertion.  \nWe recently managed a 43-year-old female patient with congenital factor 7 deficiency who progressed to end-stage kidney disease. Her clinical course and the potential causes of chronic kidney disease in patients with coagulation disorders are provided in Supplementary Material S1 and S2 .  \nHer sister was identified as a potential living kidney donor; however, routine pretransplant screening revealed the same factor 7 deficiency, thereby precluding transplantation. Currently, no guideline-based recommendations address dialysis modality selection in patients with coagulation factor deficiencies. Given this patient’s intermittent unexplained decreases in hemoglobin levels and increased risk of bleeding during hemodialysis, PD was considered a safer option. The patient was thoroughly counselled on PD, including relative merits of surgical versus percutaneous catheter insertion. A comparison of the advantages and disadvantages of percutaneous versus laparoscopic or surgical PD catheter insertion is provided in Table 1. She underwent percutaneous PD catheter placement performed by the nephrology team with periprocedural hemostatic support. The procedure was completed without complications, with only minor hemorrhagic fluid noted in the initial peritoneal effluent. Since then, the patient has been maintained on PD for a year without any significant complications. Strategies to plan renal replacement therapy in hemophiliacs is discussed in Supplementary Material S3 .  \nTable 1. Pros and cons of percutaneous versus laparoscopic insertion of peritoneal dialysis catheter  \n\n| Percutaneous insertion | Laparoscopic/surgical insertion |\n| --- | --- |\n| Pros: | Pros: |\n| No need for general anesthesia | Direct observation of abdominal structures |\n| No need for elective orotracheal intubation | Adhesiolysis may be performed |\n| Less invasive | Cons: |\n| Faster recovery | More invasive |\n| Cons: | General anesthesia needed |\n| No direct observation of abdominal structures | Orotracheal intubation needed |\n| Patient compliance is needed | Prolonged recovery time |\n\nDISCLOSURE  \nAM declares receiving honorarium from Vantive, outside of this work. All the other authors declared no competing interests.  \nPATIENT CONSENT  \nThe authors declare that they have obtained consent from the patients discussed in the report. Patient identity is blinded and all rules of the Helsinki Declaration are obeyed.  \nDATA AVAILABILITY STATEMENT  \nAll data of this report are available from the corresponding author upon a reasonable request.  \nSUPPLEMENTARY MATERIAL  \nSupplementary File (PDF)  \nSupplementary References.  \nS1 . Clinical history of the patient.  \nS2 . Reasons of chronic kidney disease in hemophiliacs. S3 . Strategies to choose appropriate renal replacement therapy in hemophiliacs.  \n1. Hassan S, Monahan RC, Mauser-Bunschoten EP, et al. Mortality, life expectancy, and causes of death of persons with hemophilia in the Netherlands 2001–2018. J Thromb Haemost. 2021;19:645–653. [https://d","cbCaiaMN5MbfeBKn","https://ap.wps.com/l/cbCaiaMN5MbfeBKn","pdf",112624,"English","# Letter to the Editor\n## Clinical challenge and rationale\n## Case description and counseling\n## Table 1: Percutaneous vs laparoscopic/surgical PD catheter insertion\n## Disclosure, patient consent, and data availability\n## Supplementary materials","[{\"question\":\"Why is choosing renal replacement therapy challenging in factor VII deficiency patients?\",\"answer\":\"End-stage kidney disease occurs increasingly in congenital coagulation factor deficiency as patients live longer, but dialysis modality selection remains clinically difficult due to high bleeding risks during surgical interventions and treatment-related procedures.\"},{\"question\":\"What dialysis option was considered safer for the reported patient and why?\",\"answer\":\"Peritoneal dialysis was considered safer because bleeding episodes were uncommon and factor replacement was generally only needed during catheter insertion, unlike hemodialysis where repeated access procedures may require additional factor infusions.\"},{\"question\":\"What does Table 1 compare regarding peritoneal dialysis catheter insertion?\",\"answer\":\"Table 1 compares pros and cons of percutaneous insertion versus laparoscopic/surgical insertion, including anesthesia needs, recovery time, the ability to directly observe abdominal structures, and recovery duration.\"}]","Planning Renal Replacement Therapy in Factor VII Deficiency - Letter to the Editor | PDF",1790703180]