[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-327627-105":59,"doc-detail-327627-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","pkib-a-novel-target-for-cancer-therapy-review","PKIB, a Novel Target for Cancer Therapy - Review","","The cyclic AMP (cAMP)-dependent serine-threonine kinase PKA has diverse roles in cellular metabolic and transcription regulation. Its endogenous inhibitor, PKIB, is one of three known PKA inhibitors, yet its function remains incompletely defined. Hormonal signaling is linked to increased PKIB expression, which correlates with worse cancer patient prognosis. PKIB also affects cancer cell behavior via transcriptional nuclear modulation and regulation of oncogenic AKT signaling, while evidence suggests possible roles beyond cancer. This review consolidates current PKIB literature for cancer and related therapeutic directions.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":10,"@type":76,"position":81},"https://docshare.wps.com/document/story-novel/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/pkib-a-novel-target-for-cancer-therapy-review/327627/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/pkib-a-novel-target-for-cancer-therapy-review/327627.png","ImageObject",300,407,{"name":92,"@type":93},"Aurora","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":81},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What are the main roles of PKIB discussed in relation to cancer?","Question",{"text":112,"@type":113},"PKIB is described as a PKA inhibitor that influences cancer cell behavior through nuclear modulation of transcriptional activation and regulation of oncogenic AKT signaling.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How is PKIB expression linked to cancer prognosis?",{"text":117,"@type":113},"Hormonal signaling is reported to correlate with increased PKIB expression through genetic regulation, and higher PKIB expression is associated with decreased cancer patient prognosis.",{"name":119,"@type":110,"acceptedAnswer":120},"What signaling pathways connect PKIB and PKA to oncogenic processes?",{"text":121,"@type":113},"The text highlights cAMP/PKA regulation of PI3K-AKT signaling, where PKA-c phosphorylates AKT at Ser473, and cAMP/PKA regulation of CREB activation via nuclear translocation of PKA-c.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},327627,1792195256,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":8,"category_name":10,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":81,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},4810365810221,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Review  \nPKIB, a Novel Target for Cancer Therapy  \nAnna Musket 1,2, Jonathan P. Moorman 1,2,3, Jinyu Zhang 1,2, * and Yong Jiang 1,2, *  \nCitation: Musket, A.; Moorman, J.P.; Zhang, J.; Jiang, Y. PKIB, a Novel Target for Cancer Therapy. Int. J. Mol.  \nSci. 2024, 25, 4664. [https://doi.org/](https://doi.org/)[ ](https://doi.org/)[10.3390/ijms25094664](10.3390/ijms25094664)  \nAcademic Editor: Maria Ruzzene  \nReceived: 22 March 2024  \nRevised: 18 April 2024  \nAccepted: 23 April 2024  \nPublished: 25 April 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA; [musket@etsu.edu](musket@etsu.edu) (A.M.); [moorman@etsu.edu](moorman@etsu.edu) (J.P.M.)  \n2 Center of Excellence in Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA  \n3 Hepatitis (HCV/HBV/HIV) Program, James H. Quillen VA Medical Center, Department of Veterans Affairs, Johnson City, TN 37614, USA  \n* Correspondence: [zhangj2@etsu.edu](zhangj2@etsu.edu) (J.Z.); [jiangy2@etsu.edu](jiangy2@etsu.edu) (Y.J.)  \nAbstract: The serine-threonine kinase protein kinase A (PKA) is a cyclic AMP (cAMP)-dependent intracellular protein with multiple roles in cellular biology including metabolic and transcription regulation functions. The cAMP-dependent protein kinase inhibitor β (PKIB) is one of three known endogenous protein kinase inhibitors of PKA. The role of PKIB is not yet fully understood. Hormonal signaling is correlated with increased PKIB expression through genetic regulation, and increasing PKIB expression is associated with decreased cancer patient prognosis. Additionally, PKIB impacts cancer cell behavior through two mechanisms; the first is the nuclear modulation of transcriptional activation and the second is the regulation of oncogenic AKT signaling. The limited research into PKIB indicates the oncogenic potential of PKIB in various cancers. However, some studies suggest a role of PKIB in non-cancerous disease states. This review aims to summarize the current literature and background of PKIB regarding cancer and related issues. In particular, we will focus on cancer development and therapeutic possibilities, which are of paramount interest in PKIB oncology research.  \nKeywords: PKA; cancer; PKIB; cyclic AMP and AKT  \n1. Introduction  \nCyclic AMP-dependent protein kinase A (PKA) is a family of holoenzymes that are cyclic AMP (cAMP) effector proteins heavily involved in metabolic processes, including sugar and lipid metabolism, as well as genetic regulation through cAMP response elementbinding protein (CREB) [1] . PKA is normally an inactive, tetrameric complex composed of two regulatory (PKA-r) and two catalytic subunits (PKA-c) . There are four isoforms of the regulatory subunits R1α, R1β, R2α, and R2β; additionally, there are three isoforms of the catalytic subunits Cα, Cβ, and Cγ [1] . These subunits of PKA-r and PKA-c are differentially expressed in different cell types, leading to cell-specific PKA holoenzyme formation [2] . Following activation by cAMP, the catalytic subunits phosphorylate serine and threonine in other target proteins [3] . Due to the cAMP-mediated nature of PKA activation, PKA is seen as a classical example of an effector protein for cAMP signaling [4] . Additionally, PKA is a highly conserved protein, and both cAMP and PKA are expressed ubiquitously throughout mammalian tissues and cells [5,6] . Cytosolic cAMP acts as a secondary intracellular signaling molecule to bind to the regulatory subunits to activate PKA. Each regulatory subuni","cbCaijVE7fSmiiys","https://ap.wps.com/l/cbCaijVE7fSmiiys","pdf",987451,11,"English","# Abstract\n# Keywords\n# 1. Introduction","[{\"question\":\"What are the main roles of PKIB discussed in relation to cancer?\",\"answer\":\"PKIB is described as a PKA inhibitor that influences cancer cell behavior through nuclear modulation of transcriptional activation and regulation of oncogenic AKT signaling.\"},{\"question\":\"How is PKIB expression linked to cancer prognosis?\",\"answer\":\"Hormonal signaling is reported to correlate with increased PKIB expression through genetic regulation, and higher PKIB expression is associated with decreased cancer patient prognosis.\"},{\"question\":\"What signaling pathways connect PKIB and PKA to oncogenic processes?\",\"answer\":\"The text highlights cAMP/PKA regulation of PI3K-AKT signaling, where PKA-c phosphorylates AKT at Ser473, and cAMP/PKA regulation of CREB activation via nuclear translocation of PKA-c.\"}]","PKIB, a Novel Target for Cancer Therapy - Review | PDF",1789977664,17]