[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-331527-105":59,"doc-detail-331527-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","pinx1-plays-multifaceted-roles-in-human-cancers-a-review-and-perspectives","PinX1 plays multifaceted roles in human cancers - a review and perspectives","","Pin2/TRF1 interacting protein X1 (PinX1) is a telomerase inhibitor located at chromosome 8p23, a region tied to telomere length maintenance and chromosome stability that influence human aging and disease. Research progress across human cancers is summarized, focusing on variable PinX1 expression across cancer cell types, its key roles in cancer development and progression, and its involvement in mitosis. The review highlights PinX1 effects on radiation-induced DNA damage sensitivity and outlines pathway-level mechanisms supporting therapeutic potential.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/pinx1-plays-multifaceted-roles-in-human-cancers-a-review-and-perspectives/331527/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/pinx1-plays-multifaceted-roles-in-human-cancers-a-review-and-perspectives/331527.png","ImageObject",300,407,{"name":92,"@type":93},"Quinn","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is PinX1 and why is chromosome 8p23 important for its function?","Question",{"text":112,"@type":113},"PinX1 (Pin2/TRF1 interacting protein X1) is a telomerase inhibitor located at human chromosome 8p23. This region is important for maintaining telomere length and chromosome stability, which are essential for regulating human aging and related diseases.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does PinX1 contribute to cancer progression according to the review?",{"text":117,"@type":113},"In cancers, PinX1 mRNA and protein levels vary by cancer cell type, and PinX1 plays a critical role in regulating cancer development and progression. The review also reports PinX1 involvement in mitosis and effects on cancer-cell sensitivity to radiation-induced DNA damage.",{"name":119,"@type":110,"acceptedAnswer":120},"What therapeutic potential does the review attribute to PinX1-based cancer therapy?",{"text":121,"@type":113},"PinX1 is presented as having therapeutic potential for cancer because understanding its functions in regulating cancers can improve treatment strategies. The review provides pathway-level and cellular theoretical support for PinX1-related therapies.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331527,1790057991,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},962075114765,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Molecular Biology Reports (2024) 51:1163  \n[https://doi.org/10.1007/s1](https://doi.org/10.1007/s1) 1033-024-10082-x  \nPinX1 plays multifaceted roles in human cancers: a review and perspectives  \nDian You1 · KaiwenTong1 · Yuan Li1 · Ting Zhang1 · Yongqiang Wu2 · Ling Wang2 · Guangming Chen1 · Xiaoying Zhang1  \nReceived: 30 August 2024 / Accepted: 30 October 2024 / Published online: 17 November 2024 © The Author(s) 2024  \nAbstract  \nBackground Pin2/TRF1 interacting protein X1 (PinX1), a telomerase inhibitor, is located at human chromosome 8p23 . This region is important for telomere length maintenance and chromosome stability, both of which are essential for regulating human ageing and associated diseases.  \nMethods and Results We investigated the research progress of PinX1 in human cancers. In cancers, the expression levels of PinX1 mRNA and protein vary according to cancer cell types, and PinX1 plays a critical role in the regulation of cancer development and progression. Additionally, a review of the literature indicates that PinX1 is involved in mitosis and affects the sensitivity of cancer cells to radiation-induced DNA damage. Therefore, PinX1 has therapeutic potential for cancer, and understanding the function of PinX1 in the regulation of cancers is crucial for improving treatment. In this review, we discuss the expression level of PinX1 in a variety of cancers and how it affects the implicated pathways. Additionally, we outline the function of PinX1 in cancer cells and provide a theoretical basis for PinX1-related cancer therapy.  \nConclusions PinX1 has promising prospects in future cancer therapeutics. This review may provide theoretical support for researchers in this field.  \nKeywords PinX1 · Telomerase · Function · Molecular mechanism · Cancer  \nAbbreviations  \nAR Androgen receptor  \nATC Aggressive undifferentiated thyroid cancer BLBC Basal-like breast cancer  \nBMP-5 Bone morphogenetic protein-5  \nCCA Cervical cancer  \nCRC Colorectal cancer  \nCSCC Cervical squamous cell carcinoma DFS Disease-free survival  \nDOX Doxorubicin  \nDSS Disease-specific survival DTC Differentiated thyroid cancer EBV Epstein-Barr virus Eca Esophageal cancer  \nEMT Epithelial-mesenchymal transition  \n* Xiaoying Zhang [02809@zjhu.edu.cn](02809@zjhu.edu.cn)  \n1 Huzhou Key Laboratory of Precise Prevention and Control of Major Chronic Diseases, School of Medicine, Huzhou University, 759 East 2nd Rd., Huzhou 313000, China  \n2 Botuvac Biotechnology Co., Ltd, Beijing, China  \nERα  \nESCC  \nFTC  \nGC  \nHBV  \nHCC  \nHCV  \nHPV  \nLMP1  \nLOH  \nLPTS  \nMad1  \nMCM2  \nMCRS2  \nMMP-2  \nMMP-9 MTC  \nNPC  \nNRF  \nNSCLC  \nOS  \nOS  \nEstrogen receptor α  \nEsophageal squamous cell carcinoma Follicular thyroid cancer  \nGastric cancer  \nHepatitis B virus Hepatocellular carcinoma Hepatitis C virus  \nHuman papillomavirus Latent membrane protein 1  \nLoss of heterozygosity  \nLiver-related putative tumor suppressor Mitosis arrest deficiency 1  \nMinichromosome maintenance deficient 2 Microspherule protein 2  \nMatrix metalloproteinase-2  \nMatrix metalloproteinase-9  \nMedullary thyroid cancer Nasopharyngeal carcinoma NF-κB repressing factor Non-small cell lung cancer Overall survival  \nOsteosarcoma  \nPCa Prostate cancer  \nPinX1 Pin2/TRF1 interacting protein X1 PTC Papillary thyroid cancer  \nRCC Renal cell carcinoma  \nRNAi RNA interference  \nSCLC Small cell lung cancer  \nTERC Telomerase RNA component TERT Telomerase reverse transcriptase TID Telomerase inhibitory domain TNM Tumor node metastasis  \nUCB Urothelial carcinoma of the bladder  \nVEGF Vascular endothelial growth factor  \nIntroduction  \nOwing to issues with terminus replication, the telomeres of human cells shorten by approximately 50 bp per division [1] . When telomeres shorten to a critical point, functional telomere complexes cannot be produced, resulting in cell cycle arrest, cellular senescence and apoptosis. Telomere length is one of the factors that determine the replication lifespan of human cells [2, 3]. Consequent","cbCaieQjUXiWHfTL","https://ap.wps.com/l/cbCaieQjUXiWHfTL","pdf",1588024,14,"English","# Abstract\n## Background\n## Methods and Results\n## Conclusions\n# Keywords and Abbreviations\n## Abbreviations\n# Introduction","[{\"question\":\"What is PinX1 and why is chromosome 8p23 important for its function?\",\"answer\":\"PinX1 (Pin2/TRF1 interacting protein X1) is a telomerase inhibitor located at human chromosome 8p23. This region is important for maintaining telomere length and chromosome stability, which are essential for regulating human aging and related diseases.\"},{\"question\":\"How does PinX1 contribute to cancer progression according to the review?\",\"answer\":\"In cancers, PinX1 mRNA and protein levels vary by cancer cell type, and PinX1 plays a critical role in regulating cancer development and progression. The review also reports PinX1 involvement in mitosis and effects on cancer-cell sensitivity to radiation-induced DNA damage.\"},{\"question\":\"What therapeutic potential does the review attribute to PinX1-based cancer therapy?\",\"answer\":\"PinX1 is presented as having therapeutic potential for cancer because understanding its functions in regulating cancers can improve treatment strategies. The review provides pathway-level and cellular theoretical support for PinX1-related therapies.\"}]","PinX1 plays multifaceted roles in human cancers - a review and perspectives | PDF",1789993746,35]