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A 24-week, parallel-arm randomized controlled pilot trial tested adaptive versus traditional versions of TRE and CR against a no-intervention control. Seventy healthy adults (BMI 22.0–29.9) were assigned to five groups. Adaptive CR achieved the greatest weight loss and the largest biological age shift, while healthspan improved in CR arms, with highest feasibility in adaptive groups.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/piloting-novel-nutritional-interventions-for-mechanistic-studies-of-human-aging-part-9-abstract/426766/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/piloting-novel-nutritional-interventions-for-mechanistic-studies-of-human-aging-part-9-abstract/426766.png","ImageObject",300,407,{"name":92,"@type":93},"A glass of water","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":24},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What question did this 24-week pilot trial address?","Question",{"text":112,"@type":113},"It evaluated whether adaptive versions of time-restricted eating (TRE) and calorie restriction (CR) are feasible and how their effect sizes compare with traditional approaches and a no-intervention control for human aging outcomes.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were participants assigned in the study?",{"text":117,"@type":113},"Seventy healthy adults with BMI 22.0–29.9 kg/m2 were randomized into five groups: control, traditional TRE, adaptive TRE, traditional CR targeting 25% energy restriction, and adaptive CR.",{"name":119,"@type":110,"acceptedAnswer":120},"Which intervention showed the strongest results for weight change and biological age?",{"text":121,"@type":113},"Adaptive CR produced the greatest weight reduction versus control and had the largest change in biological age effects among the tested arms over 24 weeks.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},426766,1791393908,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":24,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":81},962090760832,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Innovation in Aging, 2025, Vol. 9, No. S2 409  \nAbstract citation ID: igaf122.1391  \nPILOTING NOVEL NUTRITIONAL INTERVENTIONS  \nFOR MECHANISTIC STUDIES OF HUMAN AGING  \nCorby Martin1, and Leanne Redman2, 1. Pennington Biomedical Research Center, 2. Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States  \nCalorie restriction (CR) and time-restricted eating (TRE) have demonstrated efficacy for improving healthspan and biological age, yet long-term adherence remains problematic. Adaptive interventions may promote adherence in longer trials. This 24-week, parallel-arm, randomized controlled pilot trial compared adaptive and traditional versions of TRE and CR against a no-intervention control. Seventy (n = 70) healthy adults with body mass index 22.0-29.9 kg/m2 were randomized to one of five groups: control, traditional TRE with an 8-hour window, adaptive TRE, traditional CR targeting 25% energy restriction, or adaptive CR. The study aimed to examine intervention feasibility and effect sizes for primary aging and healthspan.  \nParticipants were 38±3 y (Mean+SD), 77% female, with mean BMI 26.0±2.6 kg/m2 . The CR arms achieved 48%(traditional) and 77.6%(adaptive) of the CR target. TRE participants adhered to the 8-hour eating window on 74.5%(traditional) and 40.1%(adaptive) of days, respectively (86% adherence reflected the goal of following TRE 6 days per week). Weight change compared to control was greatest in adaptive CR (-8.8 kg, P \u003C 0.001) followed by traditional CR (-5.8 kg, P \u003C 0.001), traditional TRE (-2.3 kg, P = 0.05) and adaptive TRE (-1.4 kg, P = 0.15) . Compared to control, biological age (Klemera-Doubal) effect sizes were modest over 24-weeks, with adaptive CR having the largest change (-1.8 y, P = 0.10; Cohen’s d = 0.24) . Compared to control, healthspan (Metabolic Syndrome Score) improved in the CR arms (traditional-2.2, P \u003C 0.01; adaptive-1.8, P = 0.02) but not in the TRE arms (traditional -0.6, P = 0.26; adaptive -0.7, P = 0.21) .  \nIntervention feasibility was highest in the adaptive groups.","cbCaikUoeuzkNng5","https://ap.wps.com/l/cbCaikUoeuzkNng5","pdf",400015,"English","# Background\n## Study design and participants\n# Results\n## Weight change and adherence\n## Biological age and healthspan\n# Feasibility conclusions","[{\"question\":\"What question did this 24-week pilot trial address?\",\"answer\":\"It evaluated whether adaptive versions of time-restricted eating (TRE) and calorie restriction (CR) are feasible and how their effect sizes compare with traditional approaches and a no-intervention control for human aging outcomes.\"},{\"question\":\"How were participants assigned in the study?\",\"answer\":\"Seventy healthy adults with BMI 22.0–29.9 kg/m2 were randomized into five groups: control, traditional TRE, adaptive TRE, traditional CR targeting 25% energy restriction, and adaptive CR.\"},{\"question\":\"Which intervention showed the strongest results for weight change and biological age?\",\"answer\":\"Adaptive CR produced the greatest weight reduction versus control and had the largest change in biological age effects among the tested arms over 24 weeks.\"}]","PILOTING NOVEL NUTRITIONAL INTERVENTIONS FOR MECHANISTIC STUDIES OF HUMAN AGING - Part 9 - Abstract | PDF",1790641722]