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This pilot study compared capillary blood collected with a Tasso+ device against venous samples processed immediately, then tested storage temperatures and holding times to model shipping effects. Capillary and venous proteomes were similar for immediate processing; delays beyond 48 hours caused major protein changes, while holding at lower temperatures reduced proteome alterations.",{"@graph":14,"@context":72},[15,34,55],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/pilot-study-to-determine-the-efficacy-feasibility-and-impact-of-storage-conditions-on-at-home-blood-collection-kits-for-proteomic-studies-research-findings/657693/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/pilot-study-to-determine-the-efficacy-feasibility-and-impact-of-storage-conditions-on-at-home-blood-collection-kits-for-proteomic-studies-research-findings/657693.png","ImageObject",300,407,{"name":42,"@type":43},"Ophelia","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-29","2026-10-26",true,{"@type":52,"interactionType":53,"userInteractionCount":30},"InteractionCounter",{"@type":54},"ViewAction",{"@type":56,"mainEntity":57},"FAQPage",[58,64,68],{"name":59,"@type":60,"acceptedAnswer":61},"What was the goal of this pilot study?","Question",{"text":62,"@type":63},"To determine how storage conditions affect proteome measurements from at-home blood collection kits, comparing capillary collection with Tasso+ to gold-standard venous samples.","Answer",{"name":65,"@type":60,"acceptedAnswer":66},"How were the capillary and venous samples collected and analyzed?",{"text":67,"@type":63},"Capillary blood was collected with a Tasso+ device and compared with venous blood drawn by a trained phlebotomist; protein levels were measured using the SomaScan 7K proteomic assay.",{"name":69,"@type":60,"acceptedAnswer":70},"What storage or shipping factors had the largest impact on the serum proteome?",{"text":71,"@type":63},"Processing delays greater than 48 hours produced large changes in detected protein levels across the serum proteome, while lower holding temperatures (e.g., refrigeration above 4°C in the study description) reduced the magnitude of these changes.","https://schema.org",{"og:url":32,"og:type":74,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":76,"canonical":32},"index,follow",{"doc_id":78,"site_id":7},657693,1793095635,{"code":4,"msg":81,"data":82},"success",[83,87,91,95,100,105,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":84,"show_sort_weight":85,"slug":86},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":88,"show_sort_weight":89,"slug":90},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":92,"show_sort_weight":93,"slug":94},"Exam",70,"exam",{"id":96,"doc_module":4,"doc_module_name":25,"category_name":97,"show_sort_weight":98,"slug":99},5,"Comic",60,"comic",{"id":101,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},6,"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":107,"show_sort_weight":108,"slug":109},7,"Healthcare",40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},8,30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":96,"slug":129},19,"General","general",{"code":4,"msg":81,"data":131},{"doc_id":78,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":111,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":30,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145},7971461741311,"https://ap-avatar.wpscdn.com/avatar/74000253aff267980c6?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779345379180704826","Pilot Study to Determine the Effi cacy, Feasibility, and Impact of Storage Conditions on At-Home Blood Collection Kits for Proteomic Studies  \nCaroline Scranton  \nThe University of Arizona  \nXiaoxiao Sun  \nThe University of Arizona  \nDominic Rodriguez  \nThe University of Arizona  \nKristen Pogreba Brown  \nThe University of Arizona  \nErika Austhof  \nThe University of Arizona  \nCaitlyn M McFadden  \nThe University of Arizona  \nVictoria Obergh  \nThe University of Arizona  \nKerry K Cooper  \nThe University of Arizona  \nResearch Article  \nKeywords: Proteomics, capillary, shipping, blood collection, storage  \nPosted Date: August 19th, 2026  \nDOI: [https://doi.org/10.21203/rs.3.rs-8737461/v1](https://doi.org/10.21203/rs.3.rs-8737461/v1)  \nLicense: 􀁱 􀅏 This work is licensed under a Creative Commons Attribution 4.0 International License.  \nRead Full License  \nAdditional Declarations: No competing interests reported.  \n1 Pilot Study to Determine the Efficacy, Feasibility, and Impact of Storage Conditions on At-  \n2 Home Blood Collection Kits for Proteomic Studies 3  \n4 Caroline Scranton 1, Xiaoxiao Sun2, Dominic Rodriguez 1, Kristen Pogreba Brown2,3, Erika  \n5 Austhof2, Caitlyn M McFadden2, Victoria Obergh 1, Kerry K Cooper 1,3* 6  \n7 1School of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, AZ, 8 USA  \n9 2Department of Epidemiology and Biostatistics, The University of Arizona, Tucson, AZ, USA  \n10 3 BIO5 Institute, University of Arizona, Tucson, AZ 85719, USA 11  \n12 *Corresponding author:  \n13 Kerry K Cooper  \n14 1117 E. Lowell St.  \n15 Tucson, AZ 85721  \n16 Phone: +1-520-621-3342  \n17 [Email: kcooper@arizona.edu](Email: kcooper@arizona.edu)[ ](Email: kcooper@arizona.edu)18  \n19 Short title: Effects of storage conditions of capillary blood for proteomics 20  \n21 Key words: Proteomics, capillary, shipping, blood collection, storage 22  \n23 Abbreviations: PCA (principal components analysis), RFU (relative fluorescence units), L2FC 24 (log 2-fold change), SST (serum separating tube), KEGG (Kyoto encyclopedia of genes and 25 genomes)  \n26  \n27  \n28  \n29  \n30  \n31  \n32  \n33  \n34  \n35  \n36  \n37  \n38  \n39  \n40  \n41  \n42  \n43  \n44  \n45  \n46 Abstract  \n47 Background: At-home blood collection kits have the potential to greatly increase the efficiency  \n48 of blood collection for diagnostic or research purposes by reducing the cost and burden on  \n49 participants, researchers, or physicians and eliminating the need for a phlebotomist, specialized  \n50 equipment, and on-site processing. These kits have shown to be effective for studying specific  \n51 blood metabolites and proteins, but for analyses targeting the entire proteome, their effectiveness  \n52 is unknown.  \n53 Methods: For this pilot study, data on human serum proteome was compared when blood was  \n54 capillary-collected with a Tasso+ device (Tasso Inc.) versus the gold-standard venous samples  \n55 drawn by a trained phlebotomist. Analyses were conducted using the SomaScan 7K assay  \n56 (SomaLogic Inc.), which assesses the levels of nearly 7,600 serum proteins. Additionally, duplicate  \n57 Tasso+ blood samples were also subjected to a variety of pre-processing storage temperatures and  \n58 times to mimic the effects of shipping samples from participants on the serum proteome compared  \n59 to baseline samples.  \n60 Results: Minimal differences were seen between the serum proteome results of capillary and  \n61 venous blood for all participants. Delays in processing of greater than 48 hours led to large changes  \n62 in detected protein levels throughout the serum proteome, while lower holding temperatures  \n63 (refrigeration at >4oC) pre-processing decreased the amount of change in the serum proteome.  \n64 Conclusions: Overall, it was determined that when processed immediately, capillary blood gives  \n65 similar results to venous blood, while minimizing the time ( \u003C48 hrs) and temperature ( \u003C4oC) can 66 minimize the serum proteome changes in samples collected by ","cbCaiith4UilQLW4","https://ap.wps.com/l/cbCaiith4UilQLW4","pdf",2070654,41,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusions\n# Introduction","[{\"question\":\"What was the goal of this pilot study?\",\"answer\":\"To determine how storage conditions affect proteome measurements from at-home blood collection kits, comparing capillary collection with Tasso+ to gold-standard venous samples.\"},{\"question\":\"How were the capillary and venous samples collected and analyzed?\",\"answer\":\"Capillary blood was collected with a Tasso+ device and compared with venous blood drawn by a trained phlebotomist; protein levels were measured using the SomaScan 7K proteomic assay.\"},{\"question\":\"What storage or shipping factors had the largest impact on the serum proteome?\",\"answer\":\"Processing delays greater than 48 hours produced large changes in detected protein levels across the serum proteome, while lower holding temperatures (e.g., refrigeration above 4°C in the study description) reduced the magnitude of these changes.\"}]","Pilot Study to Determine the Efficacy, Feasibility, and Impact of Storage Conditions on At-Home Blood Collection Kits for Proteomic Studies - Research Findings | PDF",1792986387,103]