[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-427369-105":59,"doc-detail-427369-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","pilot-study-results-testing-the-impact-of-blueberries-in-sedentary-older-adults-with-depressive-symptoms","PILOT STUDY RESULTS - Testing the impact of blueberries in sedentary older adults with depressive symptoms","","Blueberries contain fiber and anthocyanins that may influence inflammation, gut microbiota, and clinical outcomes in older adults. A randomized, double-blind, parallel pilot study tested whether 48 g/day freeze-dried blueberry powder for 12 weeks reduces inflammation, alters stool microbial profiles, and improves mood, motivation, and daily steps versus placebo. No baseline-to-follow-up changes were found in serum inflammation markers, motivation, or step count in either group. In stool-sample subsets, gut diversity did not change, but enzyme-related microbiota indicators shifted in the blueberry group after multiple-comparison adjustment. Mood improved in both groups, with a larger effect in the blueberry arm; results are preliminary and further analyses are ongoing.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/pilot-study-results-testing-the-impact-of-blueberries-in-sedentary-older-adults-with-depressive-symptoms/427369/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/pilot-study-results-testing-the-impact-of-blueberries-in-sedentary-older-adults-with-depressive-symptoms/427369.png","ImageObject",300,407,{"name":92,"@type":93},"Liam","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-19","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":24},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the study design and intervention duration?","Question",{"text":112,"@type":113},"The study was a randomized, double-blind, parallel pilot trial. Participants consumed 48 g/day freeze-dried blueberry powder or placebo for 12 weeks.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Did blueberries change inflammation markers, motivation, or step count?",{"text":117,"@type":113},"No. Compared with baseline, serum inflammation markers, motivation levels, and step count showed no changes in either group.",{"name":119,"@type":110,"acceptedAnswer":120},"What changes were observed in gut microbiota-related measures?",{"text":121,"@type":113},"Gut microbial diversity did not change in either group, but indicators of gut microbial enzymes (such as biotin metabolism) changed significantly in the blueberry group after adjusting for multiple comparisons.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},427369,1790949145,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":24,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":81},8796095461564,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Innovation in Aging, 2025, Vol. 9, No. S2 715  \nAbstract citation ID: igaf122.2436  \nPILOT STUDY RESULTS TESTING THE IMPACT OF BLUEBERRIES IN SEDENTARY OLDER ADULTS WITH DEPRESSIVE SYMPTOMS  \nCourtney Millar1, Alyssa Dufour1, Alex Wolfe2, Jasmin Kuo2, Kathryn Baldyga2, Douglas Kiel3, and Lewis Lipsitz4, 1. Hinda and Arthur Marcus Institute for Aging Research, Boston, Massachusetts, United States, 2. Hebrew SeniorLife, Boston,  \nMassachusetts, United States, 3. Harvard Medical School Hebrew SeniorLife Marcus Institute, Boston, Massachusetts, United States, 4. Hebrew Senior Life, Boston, Massachusetts, United States  \nBlueberries provide 2 bioactive nutrients, fiber and anthocyanins, that could modify inflammation, the gut microbiota, and clinical outcomes in older adults. We hypothesize consuming blueberries would decrease inflammation, change the gut microbiota, and improve mood, motivation, and daily step count. We conducted a randomized, double-blind, parallel pilot study in older adults with sedentary behavior and mild depressive symptoms. Par∼ticipants consumed 48g/day of freeze-dried blueberry  \npowder ( 2 cups of fresh berries) or a placebo powder for 12 weeks. Outcomes were measured before and after the intervention. Shotgun sequencing of the stool evaluated gut microbial diversity, abundance, and EC (enzyme commissions) . Student’st-test assessed within group differences between baseline and follow-up. Twenty-two participants completed the intervention (mean age 73 years ± 5, 77% female, 90% white, compliance >89% in both groups) . Compared to baseline there was no changes in serum inflammation markers, motivation levels, or step count in either group. In a subset of individuals who provided stool samples there was no change in gut microbial diversity in either group (n = 10 blueberry; n = 8 placebo), but there was a statistically significant change in indicators of gut microbial enzymes (e.g., biotin metabolism) between baseline and follow-up in the blueberry group after adjusting for multiple comparisons. Although both groups demonstrated an improvement in mood over time (e.g., via validated questionnaire), the magnitude appeared larger in the blueberry group. Data are preliminary and more robust analyses (e.g., mixed regression) are underway. Such data are needed to determine a potential link between blueberries, the gut-microbiota, and mood.","cbCaie36MGXskK3F","https://ap.wps.com/l/cbCaie36MGXskK3F","pdf",657240,"English","# Abstract\n## Study design and intervention\n## Outcomes: inflammation, motivation, steps\n## Gut microbiota findings\n## Mood results and limitations","[{\"question\":\"What was the study design and intervention duration?\",\"answer\":\"The study was a randomized, double-blind, parallel pilot trial. Participants consumed 48 g/day freeze-dried blueberry powder or placebo for 12 weeks.\"},{\"question\":\"Did blueberries change inflammation markers, motivation, or step count?\",\"answer\":\"No. Compared with baseline, serum inflammation markers, motivation levels, and step count showed no changes in either group.\"},{\"question\":\"What changes were observed in gut microbiota-related measures?\",\"answer\":\"Gut microbial diversity did not change in either group, but indicators of gut microbial enzymes (such as biotin metabolism) changed significantly in the blueberry group after adjusting for multiple comparisons.\"}]","PILOT STUDY RESULTS - Testing the impact of blueberries in sedentary older adults with depressive symptoms | PDF",1790643659]