[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-354013-105":59,"doc-detail-354013-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","piezo-channels-in-tumors-review","Piezo channels in tumors - Review","","Malignant tumors endanger global health, with progression shaped by genetic mutations and the tumor microenvironment’s mechanical conditions, including increased stiffness, elevated fluid pressure, and compression acting on circulating tumor cells. Mechanosensitive pathways translate these mechanical cues into intracellular signals. Piezo1/2 channels sense membrane tension through their trimeric structure, drive calcium influx, and activate downstream signaling, influencing proliferation, migration, immune remodeling, and cancer stem-like transformation while correlating with staging and prognosis.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/piezo-channels-in-tumors-review/354013/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/piezo-channels-in-tumors-review/354013.png","ImageObject",300,407,{"name":92,"@type":93},"Riley West","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How do Piezo channels connect tumor microenvironment mechanics to tumor cell behavior?","Question",{"text":112,"@type":113},"Piezo1/2 sense membrane tension and mediate calcium influx, activating mechanosensitive downstream pathways that regulate proliferation, migration, immune remodeling, and stem-like transformation.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What evidence is discussed about Piezo1 expression in different cancers?",{"text":117,"@type":113},"Piezo1 is described as upregulated in breast, esophageal, colorectal, glioma, and prostate cancers, while downregulation in lung cancer is linked to enhanced malignancy.",{"name":119,"@type":110,"acceptedAnswer":120},"What is the proposed mechanism linking mechanical compression to metastasis?",{"text":121,"@type":113},"Mechanical compression in microcapillaries can activate the Piezo1 channel, promoting circulating tumor cells to acquire stem cell-like properties via calcium signaling, thereby increasing metastatic potential.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},354013,1790668169,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},1099523885074,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","Journal of Cancer Research and Clinical Oncology (2026) 152:87  \n[https://doi.org/10.1007/s00432-026-06474-0](https://doi.org/10.1007/s00432-026-06474-0)  \nREVIEW  \nPiezo channels in tumors  \nWenxin Zhang1,2,3 · Liangliang Dai1,2,3 · Honglei Shi1,2,3  \nReceived: 29 January 2026 / Accepted: 28 March 2026 © The Author(s) 2026  \nAbstract  \nIntroduction Malignant tumors currently pose a significant threat to global health. Tumor progression is jointly regulated by genetic mutations and the mechanical properties of the tumor microenvironment (TME), including increased tissue stiffness, elevated fluid pressure, and mechanical compression experienced by circulating tumor cells (CTCs) within microvessels. These mechanical signals are transmitted through mechanosensitive pathways, with the Piezo channel family (Piezo1/ Piezo2) serving as a core mediator.With their propeller-like trimeric structure, Piezo channels sense membrane tension, mediate calcium influx, and activate downstream signaling pathways (e.g., MAPK, PI3K/AKT/mTOR, YAP/TAZ), thereby regulating tumor cell proliferation, migration, immune microenvironment remodeling, and cancer stem cell-like transformation. Its expression exhibits tissue specificity and correlates with tumor staging, invasiveness, and pro gnosis.  \nResults Piezo1 is upregulated in breast, esophageal, colorectal, glioma, and prostate cancers to promote tumor progression, while its downregulation in lung cancer enhances malignancy.Notably, the Piezo1 channel can be activated by mechanical compression in microcapillaries, subsequently promoting circulating tumor cells to acquire stem cell-like properties through calcium signaling pathways, thereby enhancing their metastatic potential. This discovery not only reveals the pivotal role of mechanical forces in tumor metastasis but also positions the Piezo channel as a promising biomarker for tumor diagnosis and prognostic assessment. Currently, targeted strategies for the Piezo channel—including small-molecule modulators and treatments based on piezoelectric materials—are gradually opening new avenues for precision cancer therapy, although issues such as tissue specificity of function and drug selectivity require further exploration.  \nConclusion Overall, as a vital bridge linking mechanical signals in the tumor microenvironment to cellular biological behavior, Piezo channels hold significant importance for deepening our understanding of tumor mechanisms, developing novel biomarkers, and optimizing therapeutic strategies.  \nKeywords Piezo · Tumor · Cancer  \nIntroduction  \nIn recent years, malignant tumors have become one of the major factors threatening human health worldwide (Brayet al. 2024) . According to statistics, the number of cancer  \n􀀍 Honglei Shi [dashi7810@163.com](dashi7810@163.com)  \n1 Department of Urology, Wujin Hospital Affiliated with Jiangsu University, Changzhou 213004, China  \n2 Department of Urology, The Wujin Clinical College of Xuzhou Medical University, Changzhou 213004, China  \n3 Changzhou medical center of Nanjing Medical University, Changzhou 213004, China  \ndeaths worldwide is projected to reach 18.5 million by 2050 (Bizuayehu et al. 2024) .  \nThe development and progression of cancer represent a complex pathological process involving the combined effects of genetic mutations and microenvironmental factors. Among these, the tumor microenvironment (TME) has been identified as a key driver of cancer progression. Within the TME, diverse cellular and non-cellular components—including blood vessels, immune cells, fibroblasts, endothelial cells, and the extracellular matrix (ECM)—interact synergistically to promote tumor growth and metastasis (Zhang et al. 2026, Ferrari et al. 2019) . Compared to normal tissues, excessive deposition and cross-linking of the extracellular matrix (ECM) within the tumor microenvironment often leads to a significant increase in tissue stiffness. In some tumor tissues, stiffness can reach 10–100 times that  \n1 3","cbCaigcE0EkEAxGD","https://ap.wps.com/l/cbCaigcE0EkEAxGD","pdf",1273333,13,"English","# Introduction\n## Tumor microenvironment mechanics and mechanotransduction\n## Mechanosensitive ion channels and Piezo family\n# Results\n## Piezo1 upregulation across multiple cancers\n## Mechanical compression, CTC stem-like properties, metastasis\n## Therapeutic targeting of Piezo channels","[{\"question\":\"How do Piezo channels connect tumor microenvironment mechanics to tumor cell behavior?\",\"answer\":\"Piezo1/2 sense membrane tension and mediate calcium influx, activating mechanosensitive downstream pathways that regulate proliferation, migration, immune remodeling, and stem-like transformation.\"},{\"question\":\"What evidence is discussed about Piezo1 expression in different cancers?\",\"answer\":\"Piezo1 is described as upregulated in breast, esophageal, colorectal, glioma, and prostate cancers, while downregulation in lung cancer is linked to enhanced malignancy.\"},{\"question\":\"What is the proposed mechanism linking mechanical compression to metastasis?\",\"answer\":\"Mechanical compression in microcapillaries can activate the Piezo1 channel, promoting circulating tumor cells to acquire stem cell-like properties via calcium signaling, thereby increasing metastatic potential.\"}]","Piezo channels in tumors - Review | PDF",1790108470,33]