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Phytochemical screening confirmed flavonoids, phenolics, and triterpenoids, while optimization targeted particle size, zeta potential, and solubility using a factorial design and multiple analytical characterizations.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/phytochemical-screening-formulation-and-optimization-of-ehretialaevis-loaded-silver-nanogel-research-paper/156185/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/phytochemical-screening-formulation-and-optimization-of-ehretialaevis-loaded-silver-nanogel-research-paper/156185.png","ImageObject",300,407,{"name":42,"@type":43},"River Wang","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-27","2026-08-28",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",15,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What was the main goal of preparing the silver nanoparticle-loaded nanogel?","Question",{"text":63,"@type":64},"To prepare, characterize, and optimize an AgNP-loaded nanogel from Ehretia laevis leaf extract using green synthesis, targeting improved topical wound healing by addressing poor permeation and slow inflammation.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Which phytochemicals and analytical techniques were used?",{"text":68,"@type":64},"Phytochemical screening verified flavonoids, phenolic compounds, and triterpenoids. Characterization used UV-Vis, FTIR, LC-MS QTOF, FESEM, and XRD.",{"name":70,"@type":61,"acceptedAnswer":71},"How were the nanogel formulations optimized and what key properties were achieved?",{"text":72,"@type":64},"Optimization used a 3-level factorial design to achieve desired particle size, zeta potential, and solubility. 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Green method was used to prepare AgNPs, which were optimized through a 3-level factorial design in order to obtain the desired size of the particle, zeta potential and solubility. UV-Vis spectroscopy, FTIR, LC-MS QTOF (detecting 28 bioactive compounds), FESEM (morphology) and XRD (crystallinity) were used as the methods of characterization. The optimized AgNPs were placed in a carbopol-based gel where they were tested in terms of physicochemical characteristics (pH, viscosity, spreadability), drug release, antimicrobial activity, and antioxidant potential.  \nResults The optimized AgNPs had an average hydrostatic diameter of 103.4 nm, zeta potential of-28.7 mV, a solubility of 0.877 mg/mL, a round shape, crystalline structure, and a 97.54% solubility of drug. The nanogel exhibited optimal properties: PH 7, viscosity 3655 cps, spreadability 3.1 [g.cm/s](g.cm/s) and drug release 97.54%. The Ehretia laevis phytochemical synergies and AgNPs were found to improve antimicrobial and antioxidant effects.  \nConclusion The Ehretia laevis AgNP-loaded nanogel is a potentially suitable therapy in topical wound healing because of its better physicochemical, release, and bioactivity characteristics. Efficacy and safety needs additional in vivo and clinical trials to prove.  \nKeywords Nanogel · Ehretia laevis · Flavonoids · LC-MS QTOF · Antioxidant  \nIntroduction  \nWound healing is a complicated physiological process with a sequence of cellular and molecular activities such ashemostasis, proliferation, inflammation, and tissue repair to restore skin integrity to injured skin [1] . Effective wound healing formulations should be developed, which will accelerate this process and prevent infections and regenerate tissues with the delivery of bioactive agents in a targeted and controlled manner. The drugs of this type might be gels,  \n􀀍 Imran Jameel Syed [imranpharm07@gmail.com](imranpharm07@gmail.com)  \nRana Zainuddin Ahmed  \n[Ranazainy@gmail.com](Ranazainy@gmail.com)  \n1 SBSPM’s B. Pharmacy College, Beed, Ambajogai, India 2 Y. B. Chavan College of Pharmacy, Aurangabad, India  \nointments, or nanogels and frequently include antimicrobial and anti-inflammatory substances to solve problems, such as chronic wounds, microbial infections, etc [2] .Out of these, nanoparticle-loaded nanogels have proved to be advanced carriers, and these systems are associated with better drug delivery, better penetration and prolonged delivery required to achieve the best wound healing results. Chronic wounds, diabetic ulcers, or burns exert deformations on the physiology of wound healing, resulting in protracted inflammation or inhibition of angiogenesis or infection susceptibility [3] . These disorders are marked by defective regulation of cellular functions such as excessive oxidative stress, impaired collagen production, and continual microbial colonization, and slowing of tissue healing processes [4] .  \nThe difficulties associated with drug delivery that inhibit effective disease targeting in wound healing include po","cbCaieGGNpnGrIq8","https://ap.wps.com/l/cbCaieGGNpnGrIq8","pdf",4138651,21,"English","# Introduction\n# Materials and Methods\n## Phytochemical screening and green synthesis\n## Experimental design and optimization\n## Characterization methods\n# Results and Discussion\n## Physicochemical properties and drug release\n## Antimicrobial and antioxidant effects\n# Conclusion and Future Work","[{\"question\":\"What was the main goal of preparing the silver nanoparticle-loaded nanogel?\",\"answer\":\"To prepare, characterize, and optimize an AgNP-loaded nanogel from Ehretia laevis leaf extract using green synthesis, targeting improved topical wound healing by addressing poor permeation and slow inflammation.\"},{\"question\":\"Which phytochemicals and analytical techniques were used?\",\"answer\":\"Phytochemical screening verified flavonoids, phenolic compounds, and triterpenoids. Characterization used UV-Vis, FTIR, LC-MS QTOF, FESEM, and XRD.\"},{\"question\":\"How were the nanogel formulations optimized and what key properties were achieved?\",\"answer\":\"Optimization used a 3-level factorial design to achieve desired particle size, zeta potential, and solubility. The optimized nanogel showed average hydrostatic diameter 103.4 nm, zeta potential -28.7 mV, pH 7, viscosity 3655 cps, and drug release 97.54%.\"}]","Phytochemical Screening, Formulation and Optimization of Ehretialaevis Loaded Silver Nanogel - Research Paper | PDF",53]