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Nine endophytic fungi were isolated from healthy tissues of Wrightia tinctoria and assessed for phytochemical profiles, antioxidant capacity, and antibacterial effects. Xylaria rohrensis showed the strongest overall bioactivity, driven by high phenolic and flavonoid levels associated with antioxidant performance and inhibition of Gram-positive and Gram-negative bacteria. Chemical characterization used FTIR and GC–MS, supported by multivariate PCA and correlation analyses linking metabolite abundance to biological activity.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/phytochemical-and-bioactive-insights-into-endophytic-fungi-from-wrightia-tinctoria-with-emphasis-on-xylaria-rohrensis-metabolites-potential/450315/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/phytochemical-and-bioactive-insights-into-endophytic-fungi-from-wrightia-tinctoria-with-emphasis-on-xylaria-rohrensis-metabolites-potential/450315.png","ImageObject",300,407,{"name":92,"@type":93},"Aurelia","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-07","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How many endophytic fungi were isolated from Wrightia tinctoria in the study?","Question",{"text":112,"@type":113},"Nine endophytic fungi were isolated from healthy plant parts of Wrightia tinctoria and evaluated for phytochemical profiles, antioxidant properties, and antibacterial activities.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Why was Xylaria rohrensis selected for further chemical characterization?",{"text":117,"@type":113},"Xylaria rohrensis consistently showed the strongest bioactivity, with high phenolic and flavonoid contents that correlated with strong antioxidant activity and bacterial growth inhibition.",{"name":119,"@type":110,"acceptedAnswer":120},"What analytical methods were used to characterize Xylaria rohrensis metabolites?",{"text":121,"@type":113},"FTIR spectroscopy was used to identify functional groups consistent with phenolic and flavonoid compounds, while GC–MS was used to detect a diverse range of secondary metabolites, including phenolic derivatives, sterols, and fatty acids.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},450315,1790769713,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},1099514068365,"https://ap-avatar.wpscdn.com/avatar/10000253d8d9f28188e?_k=1776742907772140068","[www. nature.com/scientificreports](www. nature.com/scientificreports)  \nOPEN  \nPhytochemical and bioactive insights into endophytic fungi from Wrightia tinctoria with emphasis on Xylaria rohrensis metabolites potential  \nGarimaYadav1, Priyankaraj Sonigra1, Adhishree Nagda1, Tushar Mehta1, Abhishek Sahoo1, Mukesh Meena1􀀍 & Prashant Swapnil2  \nEndophytic fungi represent a prolific reservoir of bioactive compounds with potential therapeutic and biotechnological applications. In this study, nine endophytic fungi were isolated from healthy plant parts of the medicinal plant Wrightia tinctoria and evaluated for their phytochemical profiles, antioxidant properties, and antibacterial activities. Among them, Xylaria rohrensis consistently exhibited the strongest bioactivity, with high levels of phenolic and flavonoid contents, correlating with strong antioxidant activity and growth inhibition of both Gram-positive and Gram-negative bacteria. Based on these results, X. rohrensis was selected for further chemical characterization. Fourier-transform infrared (FTIR) spectroscopy revealed prominent absorption bands corresponding to hydroxyl, carbonyl, and aromatic functional groups, confirming the presence of phenolic and flavonoid compounds. Gas chromatography–mass spectrometry (GC–MS) analysis identified a diverse array of secondary metabolites, including phenolic derivatives, sterols, and fatty acids, several of which are known for their antioxidant and antimicrobial properties. To our knowledge, this is the first detailed report describing the metabolite composition and biological potential of X. rohrensis as an endophyte. Multivariate analyses, including principal component analysis (PCA) and correlation studies, demonstrated clear associations between metabolite abundance and biological activity. These findings highlight X. rohrensis as a promising source of novel natural products and expand our understanding of the functional roles of endophytic fungi in medicinal plants.  \nKeywords Xylaria rohrensis, Wrightia tinctoria, Antioxidant activity, Antibacterial activity, FTIR spectroscopy, Phytochemicals  \nAbbreviations  \nABTS 2,2′-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)  \nATCC American Type Culture Collection BOD Biological Oxygen Demand (Incubator) CFU Colony Forming Units  \nDPPH 2,2-Diphenyl-1-picrylhydrazyl  \nFTIR Fourier Transform Infrared Spectroscopy GAE Gallic Acid Equivalents  \nGC–MS Gas Chromatography–Mass Spectrometry IC₅₀ Half Maximal Inhibitory Concentration ITS Internal Transcribed Spacer  \nMBC Minimum Bactericidal Concentration  \nMIC Minimum Inhibitory Concentration  \n1Laboratory of Phytopathology and Microbial Biotechnology, Department of Botany, Mohanlal Sukhadia University, Udaipur 313001, Rajasthan, India. 2Department of Botany, School of Basic Sciences, Central University of Punjab, Bathinda 151401, India. 􀀍 email: [mukeshmeenamlsu@gmail.com](mukeshmeenamlsu@gmail.com); [drmukeshmeena321@mlsu.ac.in](drmukeshmeena321@mlsu.ac.in);  \n[mukeshmeenabhu@gmail.com](mukeshmeenabhu@gmail.com)  \n[www. nature.com/scientificreports/](www. nature.com/scientificreports/)  \nMTCC Microbial Type Culture Collection  \nPCA Principal Component Analysis  \nPDA Potato Dextrose Agar  \nPDB Potato Dextrose Broth  \nQE Quercetin Equivalents  \nTPC Total Phenolic Content  \nTFC Total Flavonoid Content  \nUV Ultraviolet  \nEndophytic fungi have emerged as prolific sources of bioactive secondary metabolites with considerable pharmacological and agricultural potential1. These fungi reside asymptomatically within internal plant tissues and often contribute to host defense mechanisms by producing a diverse array of bioactive compounds, including antimicrobial, antifungal, cytotoxic, and antioxidant agents2,3. Their ability to colonize plant tissues without inducing visible symptoms allows them to establish mutualistic associations, enhancing the host’s resistance to biotic and abiotic stress factors4 Such interactions frequently lead to the biosyn","cbCaijwlMCYNTVDh","https://ap.wps.com/l/cbCaijwlMCYNTVDh","pdf",5854273,14,"English","# Abstract\n# Keywords\n# Abbreviations\n# Introduction\n## Endophytic fungi as bioactive metabolite sources\n## Ethnomedicinal background of Wrightia tinctoria\n## Focus on Xylaria spp. and biosynthetic potential","[{\"question\":\"How many endophytic fungi were isolated from Wrightia tinctoria in the study?\",\"answer\":\"Nine endophytic fungi were isolated from healthy plant parts of Wrightia tinctoria and evaluated for phytochemical profiles, antioxidant properties, and antibacterial activities.\"},{\"question\":\"Why was Xylaria rohrensis selected for further chemical characterization?\",\"answer\":\"Xylaria rohrensis consistently showed the strongest bioactivity, with high phenolic and flavonoid contents that correlated with strong antioxidant activity and bacterial growth inhibition.\"},{\"question\":\"What analytical methods were used to characterize Xylaria rohrensis metabolites?\",\"answer\":\"FTIR spectroscopy was used to identify functional groups consistent with phenolic and flavonoid compounds, while GC–MS was used to detect a diverse range of secondary metabolites, including phenolic derivatives, sterols, and fatty acids.\"}]","Phytochemical and bioactive insights into endophytic fungi from Wrightia tinctoria with emphasis on Xylaria rohrensis metabolites potential | PDF",1790732857,35]