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A pretest-posttest control group design included 30 students aged 19–22 years, randomly assigned to MICT, HIIT, or a no-training control group. 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Methods: The study examined the effects of two different training methods—MICTand HIIT. This study included 30 students aged 19-22 years, using a pretest-posttest control group design. Participants were randomly assigned to MICT, HIIT, or control groups (no training) and trained three times a week for four weeks. Creatine and IL-6 levels were analyzed by blood sampling. Data analysis included descriptive statistics, normality tests, and ANOVA tests to evaluate group differences.  \nResults: HIITwas found to be more effective than MICT and the control group in reducing CK and IL-6 levels in sports students after 4 weeks of training (p\u003C 0.001) .  \nConclusion: The HIIT and MICT reduced creatine kinase and IL-6 levels compared to the control group, but HIIT was more effective in reducing creatine kinase and IL-6 levels than MICT in sports students after 4 weeks of exercise.  \nKeywords: creatine kinase, high intensity interval training, IL-6, sports student, interleukin 6, moderate intensity continous training.  \nCite This Article: Nurpratiwi, R., Suyoko, A., Rusdiawan, A., Ciptorini, A.D., Sidik, M.A., Lestari, B., Samudra, F.E., Triardhana, Y., Pranoto, A., Andriana, L.M., Kusuma, I.D.M.A.W., Ismalasari, R. 2025. High-intensity interval training was more effective than moderate-intensity interval training in lowering creatine kinase and interleukin 6 levels among sports students. Physical Therapy Journal of Indonesia 6(2): 194-201. DOI: 10.51559/ptji.v6i2.253  \nINTRODUCTION  \nUniversity students are a productive age group that often faces high academic demands. Lecture activities include attendance in class, completion of assignments, exams, and involvement in other campus organizations or activities.1 All of these things can lead to a great deal of busyness, which impacts students’lifestyles, including their physical activity levels.2 The density of their activities makes it difficult for students to get time to practice, especially for sports students. Sports students are required to maintain fitness and performance as sports students.3 Therefore, it is very important for them to choose a suitable exercise program and provide the best time efficiency.4 The selected exercise must be able to improve  \ntheir performance or maintain their fitness but must also produce maximum benefits by minimizing the risk of muscle injury so that the recovery process after training can take place quickly and they can return to activities with optimal performance in a short time.5  \nExercise interventions have a significant impact on creatine kinase (CK) and interleukin-6 (IL-6) levels in the body, especially s","cbCaia9kWIdhUfjD","https://ap.wps.com/l/cbCaia9kWIdhUfjD","pdf",217693,"English","# Introduction\n## Exercise interventions and biochemical indicators\n## HIIT vs MICT training approaches\n# Methods and Study Design\n## Participants and group allocation\n## Training protocol and frequency\n## Outcome measures and analysis\n# Results\n## CK and IL-6 changes across groups\n# Conclusion\n## Comparative effectiveness of HIIT and MICT","[{\"question\":\"What was the study’s primary aim?\",\"answer\":\"To determine whether high-intensity interval training (HIIT) is superior to medium-intensity continuous training (MICT) in lowering creatine kinase and interleukin-6 levels in sports students after four weeks of exercise.\"},{\"question\":\"How were participants assigned and what was the study design?\",\"answer\":\"Thirty students aged 19–22 were enrolled in a pretest-posttest control group design and randomly assigned to MICT, HIIT, or a control group with no training.\"},{\"question\":\"How were CK and IL-6 levels measured and analyzed?\",\"answer\":\"CK and IL-6 were measured using blood sampling. Data were analyzed with descriptive statistics, normality testing, and ANOVA to evaluate differences between groups.\"}]","Physical Therapy Journal of Indonesia (PTJI) 2025 - Volume 6 - Number 2 - Article 194-201 - High-Intensity Interval Training (HIIT) vs Moderate-Intensity Continuous Training (MICT) | PDF",1790701082]