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The molecular mechanisms driving this variation and their evolutionary origins remain unclear. This study introduces a phylogenetic Gompertzian survival framework to estimate aging parameters across 38 captive primate species, revealing strong variation in baseline hazards and adult aging rates, with aging rates more evolutionarily conserved. Aging rates show no phylogenetic covariation with baseline hazards, correlate with body weights, and suggest ape ancestors aged similarly to modern humans.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/phylogenetic-reconstruction-of-aging-rates-in-the-primate-lineage-research-paper/427361/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/phylogenetic-reconstruction-of-aging-rates-in-the-primate-lineage-research-paper/427361.png","ImageObject",300,407,{"name":92,"@type":93},"Liam","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-08","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":24},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What framework is used to estimate primate aging parameters?","Question",{"text":112,"@type":113},"The study implements a novel phylogenetic Gompertzian survival framework to leverage primate evolutionary history for parameter estimation.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How do baseline hazards and aging rates differ in evolutionary conservation?",{"text":117,"@type":113},"Baseline hazards vary significantly and show lower phylogenetic conservation, while adult aging rates are more conserved evolutionarily (Pagel lambda 0.96 vs 0.34).",{"name":119,"@type":110,"acceptedAnswer":120},"What relationships are observed between aging rates, body weight, and phylogeny?",{"text":121,"@type":113},"Aging rates strongly correlate with body weights, except for an Ape family exception, and aging rates show no phylogenetic covariation with baseline hazards, indicating different evolutionary pressures.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},427361,1790776913,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":24,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":81},8796095461564,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Innovation in Aging, 2025, Vol. 9, No. S2 675  \nAbstract citation ID: igaf122.2302  \nPHYLOGENETIC RECONSTRUCTION OF AGING  \nRATES IN THE PRIMATE LINEAGE  \nEugene Melamud1, Wendy Newton2, and Joseph Kemnitz3, 1.  \nCalico Labs, Calico Labs, California, United States, 2.  \nCleMetric, Madison, Wisconsin, United States, 3. University of  \nWisconsin–Madison, Madison, Wisconsin, United States Median lif∼espans of primates show∼nearly 10-fold variation,  \nranging from 8 years in marmosets to 80 years in humans. The molecular mechanisms that govern this variation and how they evolved remain poorly understood. In this study, we implemented a novel phylogenetic Gompertzian survival framework to leverage the evolutionary history of primates in order to estimate parameters of aging for 38 captive primate species. We find that baseline hazards (at the time of sexual maturity) and adult aging rates display significant variation, and aging rates are more evolutionarily conserved than baseline hazards (Pagel lambda=0.96 vs lambda=0.34, respectively). Furthermore, we find that aging ratesand baseline hazards do not show a pattern of phylogenetic covariation, suggesting differential evolutionary pressures may act on these traits. Aging rates were strongly correlated with body weights, with a notable exception within the Ape family, where aging rates remained approximately unchanged despite large differences in body weight. Based on the reconstruction of ancestral aging rates, we estimate that the ancestor of Apes was likely aging at a similar rate to modern humans.","cbCaifkocFPiYdYC","https://ap.wps.com/l/cbCaifkocFPiYdYC","pdf",59755,"English","# Abstract\n## Methods\n## Key findings\n## Evolutionary interpretation","[{\"question\":\"What framework is used to estimate primate aging parameters?\",\"answer\":\"The study implements a novel phylogenetic Gompertzian survival framework to leverage primate evolutionary history for parameter estimation.\"},{\"question\":\"How do baseline hazards and aging rates differ in evolutionary conservation?\",\"answer\":\"Baseline hazards vary significantly and show lower phylogenetic conservation, while adult aging rates are more conserved evolutionarily (Pagel lambda 0.96 vs 0.34).\"},{\"question\":\"What relationships are observed between aging rates, body weight, and phylogeny?\",\"answer\":\"Aging rates strongly correlate with body weights, except for an Ape family exception, and aging rates show no phylogenetic covariation with baseline hazards, indicating different evolutionary pressures.\"}]","Phylogenetic Reconstruction of Aging Rates in the Primate Lineage - Research Paper | PDF",1790643646]