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The review consolidates up-to-date literature on topical photosensitizer choices, modified light-delivery protocols, and combination regimens through studies published up to February 2023. PDT is assessed against field-directed alternatives for efficacy, safety, pain, tolerability, and cosmetic outcomes, including daylight-based approaches. Conclusions support improved clinical application and intuitive use by physicians.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/photodynamic-therapy-for-field-cancerization-in-the-skin-where-do-we-stand/375663/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/photodynamic-therapy-for-field-cancerization-in-the-skin-where-do-we-stand/375663.png","ImageObject",300,407,{"name":92,"@type":93},"Ezra","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is the main purpose of this review on PDT for field cancerization?","Question",{"text":113,"@type":114},"It aims to present up-to-date literature on skin field cancerization using PDT, focusing on different topical photosensitizers, modified light delivery protocols, and combination treatments for real-world clinical practice.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How does PDT compare with other field treatments for actinic keratoses?",{"text":118,"@type":114},"The review reports advantages of PDT over several field therapies, including better cosmetic outcomes and greater patient satisfaction, though it also notes drawbacks such as pain and longer treatment duration.",{"name":120,"@type":111,"acceptedAnswer":121},"What alternative illumination methods and preventive use are discussed?",{"text":122,"@type":114},"Alternate illumination methods, including daylight, are evaluated as well-tolerated and equally effective. The review also indicates that preventive field PDT may yield promising outcomes, especially for high-risk individuals such as organ transplant recipients.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},375663,1790461657,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},1099514068035,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Photodynamic Therapy for Field Cancerizationin the Skin: Where Do We Stand?  \nKaterina Bakirtzi1, Ilias Papadimitriou1, Efstratios Vakirlis1, Aimilios Lallas1, Eleni Sotiriou1  \n1 First Department of Dermatology and Venereology, Aristotle University of Thessaloniki, Thessaloniki, Greece  \nKey words: actinic keratosis, photodynamic therapy, skin field cancerization  \nCitation: Bakirtzi K, Papadimitriou I, Vakirlis E, Lallas A, Sotiriou E. Photodynamic Therapy for Field Cancerization in the Skin: Where Do We Stand? Dermatol Pract Concept. 2023;13(4):e2023291. DOI: [https://doi.org/10.5826/dpc.1304a291](https://doi.org/10.5826/dpc.1304a291)  \n[Accepted:](Accepted: May 29)[ May 29](Accepted: May 29), [2023](2023); Published: October 2023  \nCopyright: ©2023 Bakirtzi et al. This is an open-access article distributed under the terms of the Creative Commons  \nAttribution-NonCommercial License (BY-NC-4.0), [https://creativecommons.org/licenses/by-nc/4.0/](https://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original authors and source are credited.  \nFunding: None.  \nCompeting Interests: None.  \nAuthorship: All authors have contributed significantly to this publication.  \nCorresponding Author: Bakirtzi Katerina, MSc, Aristotle University of Thessaloniki, Delfon 124, Thessaloniki, P.O. 54643, Greece.  \nEmail: [bakirtzicatherine@hotmail.com](bakirtzicatherine@hotmail.com)  \nABSTRACT  \nIntroduction: Photodynamic therapy (PDT) with a photosensitizer is available for the treatment of multiple actinic keratoses (AKs) in a restricted skin area or, as it is established, for the field-cancerized skin.  \nObjectives: Our review aims to present the up-to-date literature on skin field cancerization using PDT employing different topical photosensitizers, modified light delivery protocols and combination treatments to obtain excellent efficacy and safety in everyday clinical practice.  \nMethods: We sought PubMed, MEDLINE, Scopus, OVID, Embase, Science Direct, Cochrane Library, Research Gate and Google Scholar for [(aminolevulinic acid OR aminolevulinate) AND photodynamic therapy] with (field-directed OR field cancerization,(actinic keratosis), and (efficacy OR effectiveness OR pain OR tolerability) for studies published until February 2023.  \nResults: Advantages of PDT compared to the other field treatments, including imiquimod, 5-fluorouracil, ingenol mebutate gel and diclofenac, reported better cosmetic outcomes and greater patient satisfaction. On the other hand, some drawbacks of field PDT include pain and treatment duration. Alternate illumination methods have also been investigated, including daylight as a light source. Pretreating the affected area may enhance photosensitizer absorption leading to better therapeutic results, while combinational treatments have also been tested. Patients prefer daylight PDT to traditional light sources since it is more well-tolerated and equally effective. Even as a preventive treatment, field PDT yields promising outcomes, especially for high-risk individuals, including organ transplant recipients.  \nConclusions: This review provides a thorough display of the field of PDT on cancerized skin, which will facilitate physicians in applying PDT more efficiently and intuitively.  \nReview | Dermatol Pract Concept. 2023;13(4):e2023291 1  \nIntroduction  \nThe permutation of light and chemical agents for managing disorders has its origins in ancient times when the ancient Egyptians and Indians first utilized psoralen to cure the depigmentation of vitiligo under sun exposure [1,2] . In 1903, Niels Finsen won Nobel Prize in Physiology or Medicine for his achievements in this niche. The same year, Von Tappeiner combined light and organic dye eosin for skin cancer treatment giving this therapy the name “photodynamic action”, which was the ancestor of modern photodynamic therapy (PDT) [1] .  \nSince the skin is the body organ ","cbCaiprPuF1jNsrp","https://ap.wps.com/l/cbCaiprPuF1jNsrp","pdf",716179,11,"English","# Abstract\n## Introduction\n## Objectives\n## Methods\n## Results\n## Conclusions\n# Introduction\n## Historical background of PDT\n## Overview of skin cancer and AK risk\n## Field cancerization concept and diagnosis\n## Field-directed treatment options\n# Photodynamic therapy in AK and field cancerization","[{\"question\":\"What is the main purpose of this review on PDT for field cancerization?\",\"answer\":\"It aims to present up-to-date literature on skin field cancerization using PDT, focusing on different topical photosensitizers, modified light delivery protocols, and combination treatments for real-world clinical practice.\"},{\"question\":\"How does PDT compare with other field treatments for actinic keratoses?\",\"answer\":\"The review reports advantages of PDT over several field therapies, including better cosmetic outcomes and greater patient satisfaction, though it also notes drawbacks such as pain and longer treatment duration.\"},{\"question\":\"What alternative illumination methods and preventive use are discussed?\",\"answer\":\"Alternate illumination methods, including daylight, are evaluated as well-tolerated and equally effective. The review also indicates that preventive field PDT may yield promising outcomes, especially for high-risk individuals such as organ transplant recipients.\"}]","Photodynamic Therapy for Field Cancerization in the Skin - Where Do We Stand? | PDF",1790215699,28]