[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-328422-105":3,"doc-detail-328422-en":80,"detail-sidebar-cat-0-en-105":98},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":73,"head_meta":75,"extra_data":77,"updated_unix":79},105,"en","photo-activated-microtubule-targeting-drugs-advancing-therapies-for-colorectal-cancer","Photo-activated microtubule targeting drugs - Advancing therapies for colorectal cancer","","Immunotherapy has improved cancer treatment, yet durable long-term survival for colorectal cancer (CRC) patients remains an unmet need. Existing combination approaches using targeted agents such as MEK or multi-kinase inhibitors can provide limited palliative benefit, but therapeutic gaps persist. New interest focuses on light-activated drugs used with optical devices to enable localized, targeted delivery of cytotoxic microtubule-targeting agents directly to colonic cancer cells. This strategy aims to improve CRC management through spatial control.",{"@graph":14,"@context":72},[15,34,55],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/photo-activated-microtubule-targeting-drugs-advancing-therapies-for-colorectal-cancer/328422/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/photo-activated-microtubule-targeting-drugs-advancing-therapies-for-colorectal-cancer/328422.png","ImageObject",300,407,{"name":42,"@type":43},"Liam","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":33},"InteractionCounter",{"@type":54},"ViewAction",{"@type":56,"mainEntity":57},"FAQPage",[58,64,68],{"name":59,"@type":60,"acceptedAnswer":61},"What unmet need remains in colorectal cancer treatment?","Question",{"text":62,"@type":63},"Long-term survival for colorectal cancer patients remains a significant unmet need despite advances in immunotherapy.","Answer",{"name":65,"@type":60,"acceptedAnswer":66},"How do photo-activated microtubule targeting drugs aim to improve treatment?",{"text":67,"@type":63},"By combining light-activated drugs with optical devices to achieve localized, targeted delivery of cytotoxic microtubule-targeting agents to cancerous cells in the colon.",{"name":69,"@type":60,"acceptedAnswer":70},"Why is combination immunotherapy still limited for CRC?",{"text":71,"@type":63},"Although some combination immunotherapies incorporating targeted drugs provide palliative benefit, substantial gaps remain in the current CRC therapeutic armamentarium.","https://schema.org",{"og:url":32,"og:type":74,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":76,"canonical":32},"index,follow",{"doc_id":78,"site_id":7},328422,1790390022,{"code":4,"msg":81,"data":82},"success",{"doc_id":78,"user_id":83,"nickname":42,"user_avatar":84,"doc_module":4,"category_id":85,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":86,"file_id":87,"file_url":88,"file_type":89,"file_size":90,"view_count":33,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":91,"language":92,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":93,"faqs":94,"seo_title":95,"seo_description":12,"update_tm":96,"read_time":97},8796095461564,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d",7,"| W | J | G | World Journal of\u003Cbr>Gastroenterology |\n| --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Gastroenterol 2024 July 14; 30(26): 3257-3260  \nDOI: 10.3748/wjg.v30.i26.3257 ISSN 1007-9327 (print) ISSN 2219-2840 (online)  \nLETTER TO THE EDITOR  \nPhoto-activated microtubule targeting drugs: Advancing therapies for colorectal cancer  \nNaresh Singh, Samantha Sharma  \nSpecialty type: Gastroenterology and hepatology  \nProvenance and peer review:  \nUnsolicited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s classification Scientific Quality: Grade B  \nNovelty: Grade B  \nCreativity or Innovation: Grade B  \nScientific Significance: Grade B  \nP-Reviewer: Fu Z  \nReceived: April 16, 2024  \nRevised: June 11, 2024  \nAccepted: June 24, 2024  \nPublished online: July 14, 2024  \nProcessing time: 84 Days and 10.1 Hours  \nNaresh Singh, Samantha Sharma, Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, United States  \nCorresponding author: Samantha Sharma, PhD, Research Scientist, Department of Medical and Molecular Genetics, Indiana University School of Medicine, 980 W Walnut Street, R3.C260, Indianapolis, IN 46202, [United States.](United States. samshar@iu.edu)[ samshar@iu.edu](United States. samshar@iu.edu)  \nAbstract  \nOver the years immunotherapy has demonstrably improved the field of cancer treatment. However, achieving long-term survival for colorectal cancer (CRC) patients remains a significant unmet need. Combination immunotherapies incorporating targeted drugs like MEK or multi-kinase inhibitors have offered some palliative benefit. Nevertheless, substantial gaps remain in the current therapeutic armamentarium for CRC. In recent years, there has been a surge of interest in exploring novel treatment strategies, including the application of light-activated drugs in conjunction with optical devices. This approach holds promise for achieving localized and targeted delivery of cytotoxic agents, such as microtubuletargeting drugs, directly to cancerous cells within the colon.  \nKey Words: Colorectal cancer; Therapy; Microtubule; Photo pharmacology; Immunotherapies  \n©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.  \nCore Tip: While progress has been made in colorectal cancer (CRC) treatment, significant challenges remain, as highlighted by the persistently low five-year survival rate. Integrating chemotherapy with other targeted therapies has shown promise, particularly in immune cold microsatellite stable or mutation-related CRCs. The emergence of personalized medicine, leveraging photo-switchable microtubule (MT)-targeted drugs, represents a novel approach in CRC management. While traditional MT-targeted drugs like taxanes have shown limited efficacy in CRC, optically controlled MT-drugs hold potential for improving treatment outcomes in CRC patients.  \n WJG  [https://www.wjgnet.com](https://www.wjgnet.com) 3257 July 14, 2024  Volume 30  Issue 26   \nSingh N et al. Targeting microtubules in CRC  \nCitation: Singh N, Sharma S. Photo-activated microtubule targeting drugs: Advancing therapies for colorectal cancer. World JGastroenterol 2024; 30(26): 3257-3260  \nURL: [https://www.wjgnet.com/1007-9327/full/v30/i26/3257.htm](https://www.wjgnet.com/1007-9327/full/v30/i26/3257.htm)  \nDOI: [https://dx.doi.org/10.3748/wjg.v30.i26.3257](https://dx.doi.org/10.3748/wjg.v30.i26.3257)  \nCould light be the key to better colorectal cancer (CRC) treatment? The recent review by Kita et al [1], titled “Recent clinical trials and optical control as a potential strategy to develop microtubule-targeting drugs in colorectal cancer management” is particularly timely and clinically relevant article offering the potential of optical control for more effective CRC treatment. The review is aimed towards improving treatment of CRC patients with a focus on the","cbCaimsEZL0o1KNM","https://ap.wps.com/l/cbCaimsEZL0o1KNM","pdf",358279,5,"English","# Letter to the Editor\n## Title and authors\n## Abstract and key words\n## Core Tip\n## Main discussion: CRC treatment gaps and emerging light-activated microtubule targeting","[{\"question\":\"What unmet need remains in colorectal cancer treatment?\",\"answer\":\"Long-term survival for colorectal cancer patients remains a significant unmet need despite advances in immunotherapy.\"},{\"question\":\"How do photo-activated microtubule targeting drugs aim to improve treatment?\",\"answer\":\"By combining light-activated drugs with optical devices to achieve localized, targeted delivery of cytotoxic microtubule-targeting agents to cancerous cells in the colon.\"},{\"question\":\"Why is combination immunotherapy still limited for CRC?\",\"answer\":\"Although some combination immunotherapies incorporating targeted drugs provide palliative benefit, substantial gaps remain in the current CRC therapeutic armamentarium.\"}]","Photo-activated microtubule targeting drugs - Advancing therapies for colorectal cancer | PDF",1789979684,13,{"code":4,"msg":81,"data":99},[100,104,108,112,116,121,124,129,134,137,141],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":101,"show_sort_weight":102,"slug":103},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":105,"show_sort_weight":106,"slug":107},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":109,"show_sort_weight":110,"slug":111},"Exam",70,"exam",{"id":91,"doc_module":4,"doc_module_name":25,"category_name":113,"show_sort_weight":114,"slug":115},"Comic",60,"comic",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":118,"show_sort_weight":119,"slug":120},6,"Technology",50,"technology",{"id":85,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":122,"slug":123},40,"healthcare",{"id":125,"doc_module":4,"doc_module_name":25,"category_name":126,"show_sort_weight":127,"slug":128},8,"Research & Report",30,"research-report",{"id":130,"doc_module":4,"doc_module_name":25,"category_name":131,"show_sort_weight":132,"slug":133},9,"Religion & Spirituality",20,"religion-spirituality",{"id":132,"doc_module":4,"doc_module_name":25,"category_name":135,"show_sort_weight":132,"slug":136},"World Cup","world-cup",{"id":138,"doc_module":4,"doc_module_name":25,"category_name":139,"show_sort_weight":138,"slug":140},10,"Lifestyle","lifestyle",{"id":142,"doc_module":4,"doc_module_name":25,"category_name":143,"show_sort_weight":91,"slug":144},19,"General","general"]