[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-455385-105":59,"doc-detail-455385-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","pharmacology-sample-items","Pharmacology Sample Items","","This document presents pharmacology-style multiple-choice clinical questions focusing on drug mechanisms, adverse effects, and therapeutic efficacy. Topics include drug-induced systemic lupus erythematosus linked to metabolic genetic polymorphisms, neurologic side effects such as parkinsonism mechanisms, antimicrobial action of trimethoprim-sulfamethoxazole, gout-related uric acid changes after alcohol exposure, cisplatin’s DNA interactions, and medication mechanisms in reflux and hypertension. It also covers toxic exposures and withdrawal syndromes, including acetaminophen-related hepatotoxicity patterns and vitamin counseling to reduce anencephaly risk.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":20,"@type":76,"position":81},"https://docshare.wps.com/document/exam/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/pharmacology-sample-items/455385/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/pharmacology-sample-items/455385.png","ImageObject",300,407,{"name":92,"@type":93},"lugxt","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-24","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":24},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How does procainamide lead to systemic lupus erythematosus, and what genetic polymorphism is tested?","Question",{"text":112,"@type":113},"The presentation is consistent with drug-induced systemic lupus erythematosus, associated with metabolism-related genetic polymorphisms, tested among the listed options.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Why is trimethoprim-sulfamethoxazole effective for Pneumocystis jirovecii pneumonia?",{"text":117,"@type":113},"Its effectiveness is attributed to inhibition of dihydrofolate reductase, impairing folate pathway synthesis needed for the pathogen.",{"name":119,"@type":110,"acceptedAnswer":120},"Which medication mechanism is used to treat gastroesophageal reflux with omeprazole?",{"text":121,"@type":113},"Omeprazole acts by inhibiting H+–K+ ATPase activity in gastric parietal cells.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},455385,1791456879,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":19,"category_name":20,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":24,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":29,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},3985747862600,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","1. Ten months after starting procainamide therapy for cardiac arrhythmias, a 56-year-old man develops arthritis and other symptoms consistent with drug-induced systemic lupus erythematosus. Results ofa blood test are positive for antinuclear antibodies. This finding is consistent with which of the following genetic polymorphisms in drug metabolism?  \n(A) Debrisoquine 4-hydroxylase deficiency  \n(B) Erythrocyte catechol-O-methyltransferase deficiency  \n(C) Glucose 6-phosphate dehydrogenase deficiency  \n(D) Phenytoin hydroxylase deficiency  \n(E) Slow acetylator phenotype  \n2. An 83-year-old man has a 2-month history of akinesia, rigidity, and tremor. He has been taking a drug for the past 7 years to control severe behavioral and psychiatric symptoms associated with dementia, Alzheimer type. This adverse effect is most likely mediated through which of the following?  \n(A) Anticholinergic effects  \n(B) Antidopaminergic effects  \n(C) Downregulation of γ-aminobutyric acid (GABA)  \n(D) Inhibition of norepinephrine reuptake  \n(E) Inhibition of serotonin reuptake  \n(F) Upregulation of GABA  \n3. A 23-year-old man with HIV infection has Pneumocystis jirovecii pneumonia. Therapy is started with trimethoprimsulfamethoxazole, and his pneumonia resolves. The pharmacotherapy was effective because of inhibition of which of the following?  \n(A) Cell wall synthesis  \n(B) Dihydrofolate reductase  \n(C) Incorporation ofp-aminobenzoic acid  \n(D) Incorporation of sterol into membranes  \n(E) Topoisomerase II  \n4. A 62-year-old man comes to the physician because of burning pain and tenderness of his right great toe 1 day after heavy ethanol consumption. Physical examination shows erythema, swelling, warmth, and tenderness of the right great toe. After a 2-week course of nonsteroidal anti-inflammatory drug treatment, his symptoms decrease in severity but do not completely resolve. The serum concentration of which of the following is most likely increased in this patient?  \n(A) Calcium  \n(B) Carotene  \n(C) Creatinine  \n(D) Iron  \n(E) Orotic acid  \n(F) Phosphate  \n(G) Uric acid  \n5. A 62-year-old man is being treated with cisplatin for small cell carcinoma of the lungs. The efficacy ofcisplatin depends on interaction with which of the following?  \n(A) DNA  \n(B) DNA polymerase  \n(C) Growth factor receptors  \n(D) Reverse transcriptase  \n(E) Ribosomes  \n1  \n6. An 18-year-old woman comes to the physician because of nausea, vomiting, and abdominal pain 1 hour after ingesting a glass of wine with dinner. Three days ago, she began antibiotic treatment for vaginitis after a wet mount preparation of vaginal discharge showed a motile protozoan. This patient most likely has been taking which of the following drugs?  \n(A) Ceftriaxone  \n(B) Chloroquine  \n(C) Clindamycin  \n(D) Metronidazole  \n7. A 20-year-old woman comes to the emergency department after ingesting at least 30 tablets of an unknown drug. Initial physical examination shows no abnormalities. Thirty-six hours later, serum AST activity is 1500 U/L, and serum ALT activity is 2000 U/L. The drug this patient ingested is most likely which of the following?  \n(A) Acetaminophen  \n(B) Aspirin  \n(C) Chlorpheniramine  \n(D) Ibuprofen  \n(E) Prednisone  \n8. A 42-year-old woman who is a chemist is brought to the emergency department because of a 1-hour history of severe abdominal cramps, nausea and vomiting, hypotension, bradycardia, sweating, and difficulty breathing due to bronchospasm and congestion. Exposure to which of the following is most likely?  \n(A) Acrylamide  \n(B) Cyanogen bromide  \n(C) Isoflurophate (DFP)  \n(D) Phentolamine  \n(E) Propranolol  \n9. A 35-year-old woman is diagnosed with gastroesophageal reflux disease. Omeprazole is administered. Which of the following is the most likely mechanism of action of this drug?  \n(A) Blockade of gastrin receptors  \n(B) Blockade of H1 receptors  \n(C) Blockade of M3 receptors  \n(D) Inhibition of H+–K+ ATPase activity  \n(E) Inhibition of synthesis of gastrin  \n10. In a 4","cbCaingdjDiWHL4e","https://ap.wps.com/l/cbCaingdjDiWHL4e","pdf",1160119,"English","# Drug-induced adverse effects\n## Mechanisms and mediators\n# Antimicrobials and treatment efficacy\n# Toxicity and withdrawal syndromes\n# Gastrointestinal and cardiovascular pharmacology\n# Reproductive counseling and vitamin risk reduction","[{\"question\":\"How does procainamide lead to systemic lupus erythematosus, and what genetic polymorphism is tested?\",\"answer\":\"The presentation is consistent with drug-induced systemic lupus erythematosus, associated with metabolism-related genetic polymorphisms, tested among the listed options.\"},{\"question\":\"Why is trimethoprim-sulfamethoxazole effective for Pneumocystis jirovecii pneumonia?\",\"answer\":\"Its effectiveness is attributed to inhibition of dihydrofolate reductase, impairing folate pathway synthesis needed for the pathogen.\"},{\"question\":\"Which medication mechanism is used to treat gastroesophageal reflux with omeprazole?\",\"answer\":\"Omeprazole acts by inhibiting H+–K+ ATPase activity in gastric parietal cells.\"}]","Pharmacology Sample Items | PDF",1790742750,15]