[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-405008-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-405008-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","pharmacological-aspects-of-prophylaxis-pre-exposure-prep-to-hiv-a-review","Pharmacological aspects of prophylaxis pre-exposure (prep) to HIV: a review","","This narrative review summarizes key pharmacological aspects of pre-exposure prophylaxis (PrEP) for HIV, focusing on how antiretroviral agents prevent infection. HIV remains a global health challenge, and the article links reduced incidence in recent decades to improved demand for prevention knowledge and adherence to PrEP use. The review highlights daily continuous antiretroviral therapy and the combined effectiveness of tenofovir (TDF) and emtricitabine (Truvada), while detailing pharmacokinetics, pharmacodynamics, half-life, elimination, drug interactions, and adverse reactions.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/pharmacological-aspects-of-prophylaxis-pre-exposure-prep-to-hiv-a-review/405008/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/pharmacological-aspects-of-prophylaxis-pre-exposure-prep-to-hiv-a-review/405008.png","ImageObject",300,407,{"name":42,"@type":43},"WPS_1790064749","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-27",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",8,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is the purpose of PrEP in preventing HIV?","Question",{"text":63,"@type":64},"PrEP is a prevention strategy that relies on daily and continuous use of antiretroviral drugs to reduce the risk of HIV infection.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Which drug combination is highlighted as effective for daily PrEP?",{"text":68,"@type":64},"The review notes the effectiveness of combining tenofovir (TDF) and emtricitabine, commercially known as Truvada, taken as two daily antiretroviral medications.",{"name":70,"@type":61,"acceptedAnswer":71},"What pharmacological topics does the review cover beyond effectiveness?",{"text":72,"@type":64},"It discusses pharmacokinetics (absorption, distribution, metabolism, excretion) and pharmacodynamics, including half-life, elimination time, possible drug interactions, adverse reactions, and mechanism of action.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},405008,1791088030,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":115,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":144,"preview_page_count":4},3985747859154,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Pharmacological aspects of prophylaxis pre-exposure (prep) to HIV: a review  \nAspectos farmacológicos da profilaxia de pré-exposição (prep) ao HIV: revisão  \nAspectos farmacológicos de la profilaxis previa a la exposición (prep) al VIH: una revisión  \nReceived: 12/14/2021 | Reviewed: 12/24/2021 | Accept: 06/25/2022 | Published: 07/05/2022  \nEdson Bruno Campos Paiva  \nORCID: [https://orcid.org/0000-0002-1074-9790](https://orcid.org/0000-0002-1074-9790)[ ](https://orcid.org/0000-0002-1074-9790)Cosmopolitan Faculty, Brazil  \n[E-mail: bcamposfarma@gmail.com](E-mail: bcamposfarma@gmail.com)  \nCaroline Rocha da Silveira  \nORCID: [https://orcid.org/0000-0002-5468-9072](https://orcid.org/0000-0002-5468-9072)[ ](https://orcid.org/0000-0002-5468-9072)Cosmopolitan Faculty, Brazil  \nE-mail: [caroline_rocha@live.com](caroline_rocha@live.com)  \nIsis de Oliveira Kosmiscky  \nORCID: [https://orcid.org/0000-0003-4832-0516](https://orcid.org/0000-0003-4832-0516)[ ](https://orcid.org/0000-0003-4832-0516)Federal University of Pará, Brazil  \nE-mail: [isis.kosmiscky@gmail.com](isis.kosmiscky@gmail.com)  \nCleiton da Costa Gomes  \nORCID: [https://orcid.org/0000-0002-2535-7300](https://orcid.org/0000-0002-2535-7300)[ ](https://orcid.org/0000-0002-2535-7300)Fibra University Center, Brazil  \nE-mail: [cleitongomesxp@gmail.com](cleitongomesxp@gmail.com)  \nSamantha Daniely Gomes Barros  \nORCID: [https://orcid.org/0000-0002-2619-8268](https://orcid.org/0000-0002-2619-8268)[ ](https://orcid.org/0000-0002-2619-8268)Higher School of the Amazon, Brazil  \nE-mail: [samanthaosteus@gmail.com](samanthaosteus@gmail.com)  \nRoselígia Antônia da Costa Farias  \nORCID: [https://orcid.org/0000-0002-6638-4954](https://orcid.org/0000-0002-6638-4954)[ ](https://orcid.org/0000-0002-6638-4954)Higher School of the Amazon, Brazil  \nE-mail: [ligiafarias6@gmail.com](ligiafarias6@gmail.com)  \nZélia de Oliveira Saldanha  \nORCID: [https://orcid.org/0000-0002-3526-5952](https://orcid.org/0000-0002-3526-5952)[ ](https://orcid.org/0000-0002-3526-5952)Federal University of Santa Catarina, Brazil  \nE-mail: [enfzeliasaldanha@yahoo.com](enfzeliasaldanha@yahoo.com)  \nAntônio Rafael Quadros Gomes  \nORCID: [https://orcid.org/0000-0002-4700-7942](https://orcid.org/0000-0002-4700-7942)[ ](https://orcid.org/0000-0002-4700-7942)Cosmopolitan Faculty, Brazil  \nE-mail: [antonio.quadros@faculdadecosmopolita.edu.br](antonio.quadros@faculdadecosmopolita.edu.br)  \nCybelle Silva do Couto Coelho  \nORCID: [https://orcid.org/0000-0002-8579-5249](https://orcid.org/0000-0002-8579-5249)[ ](https://orcid.org/0000-0002-8579-5249)Cosmopolitan Faculty, Brazil  \nE-mail: [cybellecouto@gmail.com](cybellecouto@gmail.com)  \nSabrina de Carvalho Cartágenes  \nORCID: [https://orcid.org/0000-0001-6890-0695](https://orcid.org/0000-0001-6890-0695)[ ](https://orcid.org/0000-0001-6890-0695)Cosmopolitan Faculty, Brazil  \nE-mail: [sabrina_decarvalho@yahoo.com.br](sabrina_decarvalho@yahoo.com.br)  \nAbstract  \nThis article is a narrative review of the literature which aims to describe the main pharmacological aspects of preexposure prophylaxis (PrEP) to HIV. The human immunodeficiency virus (HIV) is an infection that has affected people all over the world. However, this number has decreased in recent decades, this is due to the demand for information leading to prevention and adherence to the use of PrEP PrEP is characterized as a prevention strategy that includes the daily and continuous use of antiretroviral drugs, studies show the effectiveness of the combined use of two daily antiretroviral drugs, tenofovir (TDF) and emtricitabine, commercially known as truvada. However, it is extremely important to know and discuss the pharmacological aspects of the drug, and this involves its pharmacokinetics, which in turn includes the mechanisms of absorption, distribution, metabolism and excretion of the drug, as well as other important parameters such as the half-life and elimination time of the drug, and its possible drug interactions, adve","cbCailgq6CyqLLGA","https://ap.wps.com/l/cbCailgq6CyqLLGA","pdf",173017,"English","# Abstract\n## PrEP overview\n## Pharmacological mechanisms (pharmacokinetics and pharmacodynamics)\n## Safety, interactions, and clinical parameters","[{\"question\":\"What is the purpose of PrEP in preventing HIV?\",\"answer\":\"PrEP is a prevention strategy that relies on daily and continuous use of antiretroviral drugs to reduce the risk of HIV infection.\"},{\"question\":\"Which drug combination is highlighted as effective for daily PrEP?\",\"answer\":\"The review notes the effectiveness of combining tenofovir (TDF) and emtricitabine, commercially known as Truvada, taken as two daily antiretroviral medications.\"},{\"question\":\"What pharmacological topics does the review cover beyond effectiveness?\",\"answer\":\"It discusses pharmacokinetics (absorption, distribution, metabolism, excretion) and pharmacodynamics, including half-life, elimination time, possible drug interactions, adverse reactions, and mechanism of action.\"}]","Pharmacological aspects of prophylaxis pre-exposure (prep) to HIV: a review | PDF",1790553089,23]