[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-467393-105":59,"doc-detail-467393-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","pet-myocardial-blood-flow-asnc-practice-points-performance-interpretation-and-reporting","PET MYOCARDIAL BLOOD FLOW ASNC PRACTICE POINTS - Performance, Interpretation, and Reporting","","Practical guide for physicians to perform, interpret, and report quantitative myocardial blood flow (MBF) measurements using cardiac positron emission tomography (PET) myocardial perfusion imaging (MPI). Emphasizes MBF quantification at rest and peak stress, with stress/rest MBF ratio as myocardial blood flow reserve (MBFR), while also considering absolute rest and stress MBF values. Provides clinical scenarios where MBF adds diagnostic and prognostic value beyond traditional MPI, outlines tracer, equipment, and patient selection, and describes acquisition steps and quality control review points to ensure valid MBF reporting.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/pet-myocardial-blood-flow-asnc-practice-points-performance-interpretation-and-reporting/467393/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/pet-myocardial-blood-flow-asnc-practice-points-performance-interpretation-and-reporting/467393.png","ImageObject",300,407,{"name":92,"@type":93},"River Wang","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-02","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is MBFR and why is it important in cardiac PET MBF quantification?","Question",{"text":112,"@type":113},"MBFR is the stress/rest myocardial blood flow ratio and represents the most useful MBF measurement. It helps assess flow reserve, and interpretation should also consider absolute rest and peak stress MBF values.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"When should MBF data acquisition start relative to tracer injection?",{"text":117,"@type":113},"Start the PET scanner before tracer injection to avoid missing critically important data (such as the input function) needed for accurate MBF determination. Dynamic imaging begins at Time = 0 with intravenous tracer injection.",{"name":119,"@type":110,"acceptedAnswer":120},"What should be done if MBF quality control fails for a patient study?",{"text":121,"@type":113},"Review QC parameters relevant to the model and software used at rest and stress, attempt to address the issues, and if you cannot resolve them, do not include MBF information in the patient assessment.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},467393,1791210210,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":41,"preview_page_count":4},1099514067438,"https://ap-avatar.wpscdn.com/avatar/100002539ee87300030?x-image-process=image/resize,m_fixed,w_180,h_180&k=1780474512215547542","ASNC  \nPET MYOCARDIAL  \nBLOOD FLOW PRACTICE POINTS  \nPerformance, Interpretation, and Reporting  \nPET MYOCARDIAL BLOOD FLOW ASNC PRACTICE POINTS  \nPerformance, Interpretation, and Reporting  \nINTRODUCTION  \nThe purpose of this document is to provide a practical guide to help physicians perform, interpret, and report quantitative myocardial blood flow (MBF) measurements acquired in conjunction with cardiac positron emission tomography (PET) myocardial perfusion imaging (MPI) .  \nQuantification of MBF at rest and at peak stress is an important capability of cardiac PET that can be obtained routinely as a part of every rest/ pharmacological stress PET MPI study without lengthening the procedure or increasing radiation exposure to staff or patients. The most useful measurement is the stress/rest MBF ratio expressed as the myocardial blood flow reserve (MBFR) . Other terms for this measure have been used, including myocardial flow reserve (MFR)1,2 and coronary flow reserve (CFR) . Although MBFR is the most useful measurement, it is also important to focus on absolute rest and peak stress MBF values, discussed below.  \nThere are many clinical situations in which MBF measurements enhance the diagnostic and/or prognostic information of traditional PET MPI data (Table 1) .  \n1 Copyright © 2025 American Society of Nuclear Cardiology  \nTable 1. Examples of clinical value of PET MBF quantification beyond traditional MPI 1  \n\n| Scenario | Flow pattern |\n| --- | --- |\n| Suspect unsuccessful vasodilation | MBFR \u003C1 .2 |\n| Identify low risk for cardiovascular events | MBFR >2 has good prognosis |\n| Assess probability for LM or MVD | Global MBFR >2 reduces probability |\n| Confirm single-vessel CAD inpatients with single territory perfusion defect | Reduced MBFR in a single coronary territory |\n| Suspect MVD in patients with single territory perfusion defect | Reduced MBFR across more than one coronary territory |\n| Guide revascularization decisions inpatients with obstructive epicardial disease | Reduced global MBFR with perfusion defects |\n| Identify potential CMD in patients with INOCA or ANOCA | Normal perfusion and global decrease in MBFR |\n| Identify potential CMD in patients with epicardial CAD | Globally reduced MBFR with or without perfusion defects |\n| Identify allograft vasculopathy in heart transplant patients | Reduced rate-pressure product corrected MBFR, and/or reduced peak stress MBF |\n| ANOCA, angina with nonobstructive coronary arteries; CAD, coronary artery disease; CMD, coronary microvascular dysfunction; INOCA, ischemia with no obstructive coronary arteries; LM, left main; MBF, myocardial blood flow; MBFR, myocardial blood flow reserve; MVD, multivessel disease. |  |\n\nPERFORMING MBF MEASUREMENTS  \nTracers  \n• Evaluation of MBF in this document focuses on assessment with rubidium-82 PET MPI. Longer half-life tracers require consideration for spillover between the rest and stress injections.  \nEquipment  \n• MBF can be measured on most PET and PET/CT scanners without additional acquisition time or extra patient radiation dose.  \nPatient Selection  \n• All patients with suspected ischemia or coronary microvascular disease  \n(CMD) undergoing rest/pharmacologic stress PET MPI are candidates for quantitative MBF assessment. No special preparation is needed.  \nPET MYOCARDIAL BLOOD FLOW ASNC PRACTICE POINTS 2  \nACQUISITION OF MBF DATA  \n• MBF acquisition is performed both at rest and stress in conjunction with the standard myocardial perfusion data acquisition.  \n• Start the PET scanner before tracer injection to avoid potentially missing critically important data (eg,‘input function’) for accurate determination of MBF (Figure 1) .  \nFigure 1. Dynamic PET imaging starts with intravenous injection (Time = 0) and follows the tracer distribution first through the right heart cavities (RA/RV blood pool), then the lungs, in the left heart (LA/LV blood pool), and is gradually extracted from the blood pool and retained in the myocardium.1 Im","cbCaihETGOK9etP6","https://ap.wps.com/l/cbCaihETGOK9etP6","pdf",723798,12,"English","# Introduction\n# Performing MBF Measurements\n## Tracers\n## Equipment\n## Patient Selection\n# Acquisition of MBF Data\n## Practical Tips for Ensuring Consistent MBF Measurements\n## MBF Quality Control\n## Quality Control Failures","[{\"question\":\"What is MBFR and why is it important in cardiac PET MBF quantification?\",\"answer\":\"MBFR is the stress/rest myocardial blood flow ratio and represents the most useful MBF measurement. It helps assess flow reserve, and interpretation should also consider absolute rest and peak stress MBF values.\"},{\"question\":\"When should MBF data acquisition start relative to tracer injection?\",\"answer\":\"Start the PET scanner before tracer injection to avoid missing critically important data (such as the input function) needed for accurate MBF determination. Dynamic imaging begins at Time = 0 with intravenous tracer injection.\"},{\"question\":\"What should be done if MBF quality control fails for a patient study?\",\"answer\":\"Review QC parameters relevant to the model and software used at rest and stress, attempt to address the issues, and if you cannot resolve them, do not include MBF information in the patient assessment.\"}]","PET MYOCARDIAL BLOOD FLOW ASNC PRACTICE POINTS - Performance, Interpretation, and Reporting | PDF",1790772807]