[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-468057-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-468057-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","persons-with-epilepsy-have-an-elevated-radiosensitivity-which-may-be-mitigated-by-folic-acid","Persons with epilepsy have an elevated radiosensitivity, which may be mitigated by folic acid","","Study examines whether people with epilepsy (PWE) show altered radiosensitivity relevant to radiotherapy safety and effectiveness. Blood from 105 adult PWE was irradiated ex vivo and evaluated using 3-color fluorescence in situ hybridization across chromosome sets, with radiosensitivity quantified as mean breaks per metaphase (B/M). PWE demonstrated increased radiosensitivity versus healthy and oncological controls. Antiseizure medication patterns, especially perampanel and lacosamide, increased sensitivity, while seizure and disease factors showed no contribution. Male PWE were more radiosensitive, potentially linked to higher folic acid intake.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/persons-with-epilepsy-have-an-elevated-radiosensitivity-which-may-be-mitigated-by-folic-acid/468057/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/persons-with-epilepsy-have-an-elevated-radiosensitivity-which-may-be-mitigated-by-folic-acid/468057.png","ImageObject",300,407,{"name":42,"@type":43},"Emma Wilson","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-06","2026-09-30",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",6,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"How was radiosensitivity measured in patients with epilepsy?","Question",{"text":63,"@type":64},"Blood samples from 105 adults with epilepsy were irradiated ex vivo and analyzed with 3-color fluorescence in situ hybridization. Chromosomal aberrations were scored as breaks, and radiosensitivity was expressed as mean breaks per metaphase (B/M).","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Did people with epilepsy show higher radiosensitivity than control groups?",{"text":68,"@type":64},"Yes. PWE had a higher B/M (0.478) compared with healthy individuals (0.420) and oncological patients (0.442).",{"name":70,"@type":61,"acceptedAnswer":71},"What factors were associated with increased radiosensitivity in the study?",{"text":72,"@type":64},"Antiseizure medications tended to increase radiosensitivity, with perampanel and lacosamide showing clear increases. Male patients were more radiosensitive than female patients, possibly related to higher folic acid intake.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},468057,1791296622,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,105,109,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":107,"slug":108},7,40,"healthcare",{"id":110,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},8,"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":106,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":112,"preview_page_count":4},3848291630094,"https://eur-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","Journal of Neurology (2026) 273:66  \n[https://doi.org/10.1007/s00415-025-13593-0](https://doi.org/10.1007/s00415-025-13593-0)  \nPersons with epilepsy have an elevated radiosensitivity, which may be mitigated by folic acid  \nMelissa Kleber1 · Lukas C. F. Kuhlmann1 · Anabel Knabe1 · Jennifer Lainer1 · Stefan Schwab2 · Hajo M. Hamer2 · Stefanie Corradini1 · Luitpold Distel1 · Jenny Stritzelberger2  \nReceived: 12 December 2025 / Revised: 16 December 2025 / Accepted: 18 December 2025 / Published online: 8 January 2026 © The Author(s) 2026  \nAbstract  \nIntroduction Patients undergoing radiotherapy for cancer usually have several other comorbidities and are taking various medications. Both of these factors can affect the individual radiation sensitivity of normal tissue. We therefore studied persons with epilepsy (PWE) to determine whether they had altered radiation sensitivity.  \nMaterial and Methods Blood samples were collected from 105 adult patients with epilepsy and compared to those of healthy individuals and oncological patients. The samples were irradiated ex vivo and analyzed by 3-color fluorescence in situ hybridization. In each patient, aberrations were analyzed in 200 metaphases of chromosomes 1, 2, and 4 and scored as breaks. Radiosensitivity was determined by mean breaks per metaphase (B/M) and compared to both healthy donors and oncologic patients.  \nResults Radiosensitivity (B/M) of the PWE (n = 105, B/M: 0.478) was clearly increased compared to healthy individuals (n = 209, B/M: 0.420) and oncological patients (rectal patients and breast cancer patients, n = 319, B/M = 0.442) . Antiseizure medications tended to increase radiation sensitivity. The use of perampanel (0.505 B/M; p = 0.081) and lacosamide (0.521 B/M; p = 0.014) led to a clear increase in radiation sensitivity. Male PWE (0.502B/M, p = 0.004) were distinctly radiosensitive which may be potentially explained by the fact that women were recommended to take high doses of folic acid according to German guidelines at the time of the study. Factors like seizure frequency, epilepsy duration, polytherapy and comedication did not contribute to increased radiosensitivity.  \nConclusion PWE were clearly increased radiosensitive compared to healthy individuals and oncological patients. Male PWEs were found to be more sensitive than female PWEs. This may be due to their higher intake of folic acid, a substance which can protect against radiation.  \nKeywords Epilepsy · Radiosensitivity · Antiseizure medication · Valproate · Lacosamide · Folic acid  \nKey points  \n\n| We analyzed ex-vivo radiosensitivity in 105 persons with epilepsy (PWE)\u003Cbr>Compared to healthy individuals and patients with oncological diseases, PWE showed significantly higher radiation sensitivity |\n| --- |\n| Melissa Kleber and Lukas Kuhlmann contributed equally (shared first authorship) . |\n| Luitpold Distel and Jenny Stritzelberger contributed equally (shared senior authorship) . |\n\nExtended author information available on the last page of the article  \nMale patients were more radiosensitive than females, possibly because women were taking high folic acid doses, which may offer radioprotective effects.  \nIntroduction  \nThe challenge of radiotherapy is that it must eliminate cancerous cells while preserving the surrounding normal tissue. However, a variety of confounding factors can influence normal tissue tolerance. One such parameter is the patient's individual radiosensitivity. Radiotherapy-associated adverse effects not only impact patient’s quality of life but also potentially lead to discontinuation of therapy and even life-threatening conditions [1, 2]. By predicting individual radiosensitivity  \nand adjusting the dosing regimen, side effects and adverse events could be avoided. Using chromosomal aberrations of blood lymphocytes to predict individual radiosensitivity has the benefit of addressing chromosomal aberrations as a late endpoint in the process of radiation damage. Chromosomal aberrations ","cbCaigAqWXyyDDAg","https://ap.wps.com/l/cbCaigAqWXyyDDAg","pdf",1849493,12,"English","# Abstract\n# Introduction\n# Material and Methods\n# Results\n# Conclusion\n# Keywords\n# Key points","[{\"question\":\"How was radiosensitivity measured in patients with epilepsy?\",\"answer\":\"Blood samples from 105 adults with epilepsy were irradiated ex vivo and analyzed with 3-color fluorescence in situ hybridization. Chromosomal aberrations were scored as breaks, and radiosensitivity was expressed as mean breaks per metaphase (B/M).\"},{\"question\":\"Did people with epilepsy show higher radiosensitivity than control groups?\",\"answer\":\"Yes. PWE had a higher B/M (0.478) compared with healthy individuals (0.420) and oncological patients (0.442).\"},{\"question\":\"What factors were associated with increased radiosensitivity in the study?\",\"answer\":\"Antiseizure medications tended to increase radiosensitivity, with perampanel and lacosamide showing clear increases. Male patients were more radiosensitive than female patients, possibly related to higher folic acid intake.\"}]","Persons with epilepsy have an elevated radiosensitivity, which may be mitigated by folic acid | PDF",1790773714]