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Imaging and laboratory work-up failed to identify a definitive cause, raising concern for recurrence or metastasis. Surgical exploration and postoperative histopathology with immunohistochemistry confirmed peritoneal post-radiation angiosarcoma. Despite chemotherapy with paclitaxel, carboplatin, and bevacizumab, new abdominal and intestinal lesions emerged within months, and she died of progressive disease.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/peritoneal-post-radiation-angiosarcoma-in-a-patient-with-a-history-of-radiation-for-cervical-cancer/352257/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/peritoneal-post-radiation-angiosarcoma-in-a-patient-with-a-history-of-radiation-for-cervical-cancer/352257.png","ImageObject",300,407,{"name":92,"@type":93},"Patrick","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is post-radiation angiosarcoma (PRA) and why is it important?","Question",{"text":112,"@type":113},"PRA is a rare, invasive mesenchymal tumor that develops after prior cancer radiotherapy. It can be highly aggressive and may be diagnosed late, so clinicians should consider it in long-term survivors with new symptoms.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was the diagnosis of peritoneal PRA confirmed in this case?",{"text":117,"@type":113},"After imaging and labs did not identify a clear cause, surgical exploration was performed. Postoperative histopathology with immunohistochemistry confirmed angiosarcoma.",{"name":119,"@type":110,"acceptedAnswer":120},"What treatment was given after surgery, and what was the outcome?",{"text":121,"@type":113},"The patient received four cycles of chemotherapy with paclitaxel, carboplatin, and bevacizumab. Four months later, CT showed new lesions in the abdominal cavity and intestinal wall, and she ultimately died from disease progression.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},352257,1790207661,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":24,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},549758146520,"https://ap-avatar.wpscdn.com/avatar/80002397d8c0411e94?_k=1775819394049821470","e-ISSN 1941-5923  \n© Am J Case Rep, 2026; 27: e949701 DOI: 10. 12659/AJCR.949701  \nReceived: 2025.05.06  \nAccepted: 2025.10.07  \nAvailable online: 2025.11.21  \nPublished: 2026.01.04  \nAuthors’ Contribution: Study Design A  \nData Collection B Statistical Analysis C Data Interpretation D Manuscript Preparation E Literature Search F Funds Collection G  \nABCDE 1,2 BCF 2  \nCD 2  \nACE 2  \nCorresponding Author: Financial support: Conflict of interest:  \nPeritoneal Post-Radiation Angiosarcoma in a Patient With a History of Radiation for Cervical Cancer  \nXuan-Fang Qian* Xia-Wan Wang* He-Qing Yi  \nLin-Fa Li  \n1 Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, PR China  \n2 Department of Nuclear Medicine, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, PR China  \n* Xuan-Fang Qian nad Xia-Wan Wang contributed equally to this work  \nLin-Fa Li, e-mail: [pet-ct001@163.com](pet-ct001@163.com)  \nNone declared  \nNone declared  \nPatient: Female, 67-year-old  \nFinal Diagnosis: Peritoneal post-radiation angiosarcoma  \nSymptoms: Abdominal pain  \nClinical Procedure: —  \nSpecialty: Oncology • Radiology  \nObjective: Rare disease  \nBackground: Post-radiation angiosarcoma (PRA) is a rare, invasive mesenchymal tumor associated with prior cancer radiotherapy. The diagnostic criteria for PRA include a history of radiation exposure, the development of a new malignant tumor with a long latency period within the irradiated field, and a histological type different from that of the primary malignancy if radiation was administered for the original cancer. Although PRA can arise in any part of the body, it most commonly occurs in the skin. Only a few cases of vascular sarcoma secondary to radiotherapy for cervical cancer have been reported, and reports of peritoneal angiosarcoma following pelvic irradiation for cervical cancer are exceedingly rare.  \nCase Report: A 69-year-old woman presented with abdominal discomfort 22 years after receiving radiation therapy for cervical cancer. Imaging and laboratory evaluations failed to reveal a definitive cause, leading to suspicion of recurrence or metastasis of cervical cancer. The patient underwent surgical exploration; postoperative histopathology with immunohistochemistry confirmed the diagnosis of angiosarcoma. She subsequently received 4 cycles of chemotherapy with paclitaxel, carboplatin, and bevacizumab. However, 4 months after surgery, computed tomography revealed new lesions in the abdominal cavity and intestinal wall. The patient ultimately died of disease progression.  \nConclusions: This case illustrates a rare instance of peritoneal angiosarcoma occurring after radiotherapy for cervical cancer. Clinicians should maintain a high index of suspicion for secondary malignancies in long-term cancer survivors presenting with new-onset peritoneal symptoms. Secondary peritoneal angiosarcoma should be considered in patients with prior radiation exposure and peritoneal involvement.  \nKeywords: Radiation Injuries • Radiation  \nFull-text PDF: [https://www.amjcaserep.com/abstract/index/idArt/949701](https://www.amjcaserep.com/abstract/index/idArt/949701)  \n1607  —  2  16  \nPublisher’s note: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher  \nThis work is licensed under Creative Common AttributionNonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)  \ne949701-1  \nIndexed in: [PMC] [PubMed] [Emerging Sources Citation Index (ESCI)][Web of Science by Clarivate]  \n[Qian X.-F. et](Qian X.-F. et) al:  \nPost-radiation angiosarcoma in patient with past cervical cancer © Am J Case Rep, 2026; 27: e949701  \nIntroduction  \nPost-radiation angiosarcoma (PRA) is a rare, invasive mesenchymal tumor asso","cbCaim2uDfLTa0qQ","https://ap.wps.com/l/cbCaim2uDfLTa0qQ","pdf",987299,"English","# Introduction\n# Case Report\n## Clinical presentation and prior treatment\n## Diagnostic work-up and confirmation\n## Treatment and outcome\n# Conclusions","[{\"question\":\"What is post-radiation angiosarcoma (PRA) and why is it important?\",\"answer\":\"PRA is a rare, invasive mesenchymal tumor that develops after prior cancer radiotherapy. It can be highly aggressive and may be diagnosed late, so clinicians should consider it in long-term survivors with new symptoms.\"},{\"question\":\"How was the diagnosis of peritoneal PRA confirmed in this case?\",\"answer\":\"After imaging and labs did not identify a clear cause, surgical exploration was performed. Postoperative histopathology with immunohistochemistry confirmed angiosarcoma.\"},{\"question\":\"What treatment was given after surgery, and what was the outcome?\",\"answer\":\"The patient received four cycles of chemotherapy with paclitaxel, carboplatin, and bevacizumab. Four months later, CT showed new lesions in the abdominal cavity and intestinal wall, and she ultimately died from disease progression.\"}]","Peritoneal Post-Radiation Angiosarcoma in a Patient With a History of Radiation for Cervical Cancer | PDF",1790098581,13]